Mechanisms regulating the transport of acetic acid in Saccharomyces cerevisiae.
Abstract
Cells of the yeast Saccharomyces cerevisiae IGC 4072 grown in medium with acetic acid produced a mediated transport system for acetic acid that behaved as an electroneutral proton symport for the anionic form of the acid. The system could transport propionate and formate but not lactate and pyruvate. Uptake of labelled lactic acid was negligible, no mediated transport system activity for this acid being found. The acetate transporter was also found in cells grown in lactic acid or ethanol media, suggesting that the carrier did not require the presence of an external inducer. When cells were grown in lactic acid medium, uptake of labelled acetic acid, at pH 5.0, was biphasic and consistent with the presence of two distinct transport modes for the acid. One of these components corresponded to the acetate/proton symport, and the higher affinity system corresponded to a more general monocarboxylate carrier that could also transport lactate, pyruvate and propionate. Both systems were subject to repression by glucose, fructose, sucrose, maltose or galactose. In glucose-repressed cells, the undissociated form of the acids appeared to be the only one that could cross the plasma membrane, a diffusion mechanism being involved in the acid uptake. Under these growth conditions and when the extracellular pH was lower than that of the cytosol, accumulation of the acid could also be observed, it being a function of the delta pH.
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In S. cerevisiae, ADY2 (also called ATO1) encodes a permease-mediating uptake of acetate-propionate-formate present in ethanol or acetate-grown cells.
“In S. cerevisiae, ADY2 (also called ATO1) encodes a permease-mediating uptake of acetate–propionate–formate present in ethanol or acetate-grown cells (Casal et al., 1996; Paiva et al., 2004; Pacheco et al., 2012).”
From Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate (2015) · cites this paper as Casal et al., 1996
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Effects of Ethanol and Other Alkanols on Transport of Acetic Acid in Saccharomyces cerevisiae
Casal, M., Cardoso, H., & Leão, C. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.2.665-668.1998 · Cited by 40 · see citing works
Yeast as a Tool to Study Signaling Pathways in Mitochondrial Stress Response and Cytoprotection
Ždralević, M., Guaragnella, N., Antonacci, L., Marra, E., & Giannattasio, S. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/912147 · Cited by 38 · see citing works
Application of Eleutherine americana Crude Extract in Homemade Salad Dressing
Ifesan, B. O. T., Siripongvutikorn, S., & Voravuthikunchai, S. P. (2009) · Journal of Food Protection · doi:10.4315/0362-028x-72.3.650 · Cited by 38 · see citing works
Upcycling waste organic acids and nitrogen into single cell protein via brewer's yeast
Zeng, D., Jiang, Y., Su, Y., & Zhang, Y. (2022) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2022.133279 · Cited by 38 · see citing works
Robellet, X., Flipphi, M. J. A., Pégot, S., MacCabe, A., & Vélot, C. (2008) · Biochemical Journal · doi:10.1042/bj20080124 · Cited by 38 · see citing works
Expression of the Lactate Permease Gene JEN1 from the Yeast Saccharomyces cerevisiae
Andrade, R. P., & Casal, M. (2001) · Fungal Genetics and Biology · doi:10.1006/fgbi.2001.1254 · Cited by 38 · see citing works
Guerreiro, J. F., Mira, N. P., & Sá‐Correia, I. (2012) · PROTEOMICS · doi:10.1002/pmic.201100457 · Cited by 36 · see citing works
Paiva, S., Kruckeberg, A. L., & Casal, M. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3630737 · Cited by 36 · see citing works
Energetics and mechanism of anion permeation across formate-nitrite transporters
Atkovska, K., & Hub, J. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-11437-0 · Cited by 34 · see citing works
Ribeiro, R. A., Godinho, C. P., Vitorino, M. V., Robalo, T. T., Fernandes, F., Rodrigues, M. S., & Sá‐Correia, I. (2022) · Journal of Fungi · doi:10.3390/jof8020103 · Cited by 34 · see citing works
Impact of butyric acid on butanol formation by Clostridium pasteurianum
Regestein, L., Doerr, E. W., Staaden, A., & Rehmann, L. (2015) · Bioresource Technology · doi:10.1016/j.biortech.2015.07.085 · Cited by 32 · see citing works
Mans, R., Hassing, E.-J., Wijsman, M., Giezekamp, A., Pronk, J. T., Daran, J.-M. G., & van Maris, A. J. A. (2017) · FEMS Yeast Research · doi:10.1093/femsyr/fox085 · Cited by 32 · see citing works
Vilela, A. (2017) · Fermentation · doi:10.3390/fermentation3040051 · Cited by 31 · see citing works
Bringaud, F., Ebikeme, C., & Boshart, M. (2009) · Parasitology · doi:10.1017/s0031182009991843 · Cited by 31 · see citing works
- Authors
- Casal, M., Cardoso, H., & Leao, C.
- Affiliations
- University of Minho (PT)
- Department of Biology, University of Minho, 4719 Braga Codex, Portugal
- ORCID
- Casal, Margarida
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 1996-06-01
- Volume
- 142
- Issue
- 6
- Pages
- 1385-1390
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2115422703
- Cited by
- 200
- References
- 17
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 14 · 2020: 9 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 8 · 2015: 11 · 2014: 6 · 2013: 8 · 2012: 10
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- Saccharomyces cerevisiae, proton symport, glucose repression, lactate utilization, pyruvate uptake, pH gradient, acid accumulation
- MeSH terms
- Acetates, Biological Transport, Carbohydrates, Carrier Proteins, Diffusion, Formates, Fungal Proteins, Lactates, Propionates, Protons, Pyruvates, Saccharomyces cerevisiae, Pyruvic Acid, Acetic Acid, Lactic Acid, Monocarboxylic Acid Transporters
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