Ady2p is essential for the acetate permease activity in the yeast Saccharomyces cerevisiae

Paiva, Sandra; Devaux, Frederic; Barbosa, Sonia; Jacq, Claude; Casal, Margarida

doi:10.1002/yea.1056

Cited by 154Fungal and yeast genetics researchBacterial Genetics and BiotechnologyMicrobial Metabolic Engineering and Bioproduction

Ady2p is essential for the acetate permease activity in the yeast Saccharomyces cerevisiae

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Paiva, Sandra, Devaux, Frederic, Barbosa, Sonia, Jacq, Claude, Casal, Margarida·2004·Yeast

DOI 10.1002/yea.1056

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Abstract

To identify new genes involved in acetate uptake in Saccharomyces cerevisiae, an analysis of the gene expression profiles of cells shifted from glucose to acetic acid was performed. The gene expression reprogramming of yeast adapting to a poor non-fermentable carbon source was observed, including dramatic metabolic changes, global activation of translation machinery, mitochondria biogenesis and the induction of known or putative transporters. Among them, the gene ADY2/YCR010c was identified as a new key element for acetate transport, being homologous to the Yarrowia lipolytica GPR1 gene, which has a role in acetic acid sensitivity. Disruption of ADY2 in S. cerevisiae abolished the active transport of acetate. Microarray analyses of ady2Delta strains showed that this gene is not a critical regulator of acetate response and that its role is directly connected to acetate transport. Ady2p is predicted to be a membrane protein and is a valuable acetate transporter candidate.

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In S. cerevisiae, ADY2 (also called ATO1) encodes a permease-mediating uptake of acetate-propionate-formate present in ethanol or acetate-grown cells.
“In S. cerevisiae, ADY2 (also called ATO1) encodes a permease-mediating uptake of acetate–propionate–formate present in ethanol or acetate-grown cells (Casal et al., 1996; Paiva et al., 2004; Pacheco et al., 2012).”
From Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate (2015) · cites this paper as Paiva et al., 2004

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The Genome Characteristics and Predicted Function of Methyl-Group Oxidation Pathway in the Obligate Aceticlastic Methanogens, Methanosaeta spp
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Extension of Cellular Lifespan by Methionine Restriction Involves Alterations in Central Carbon Metabolism and Is Mitophagy-Dependent
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The disruption of JEN1 from Candida albicans impairs the transport of lactate
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“Recently, the gene YCR010c was identified as a new key element for this transport system (Paiva et al., 2004).”
Background
Crystal structure of the bacterial acetate transporter SatP reveals that it forms a hexameric channel
Sun, P., Li, J., Zhang, X., Guan, Z., Xiao, Q., Zhao, C., Song, M., Zhou, Y., Mou, L., Ke, M., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003876 · Cited by 47 · see citing works
Presence of the Fps1p aquaglyceroporin channel is essential for Hog1p activation, but suppresses Slt2(Mpk1)p activation, with acetic acid stress of yeast
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Snf1/AMPK regulates Gcn5 occupancy, H3 acetylation and chromatin remodelling at S. cerevisiae ADY2 promoter
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“The ADY2 gene belongs to the class of glucose-regulated genes and functions as an acetate transporter and is involved in nitrogen utilisation [32,33].”
Background
Membrane transporters in the bioproduction of organic acids: state of the art and future perspectives for industrial applications
Soares‐Silva, I., Ribas, D. M. N., Sousa-Silva, M., Azevedo‐Silva, J., Rendulić, T., & Casal, M. (2020) · FEMS Microbiology Letters · doi:10.1093/femsle/fnaa118 · Cited by 43 · see citing works
“Upon glucose depletion, lactate consumption was also more pronounced in cells expressing Jen1 and/or Ady2, suggesting the involvement of these transporters in both the import and export of lactic acid (Pacheco et al. 2012).”
BackgroundInfluential
Characterization of an acyl‐CoA: carboxylate CoA‐transferase from Aspergillus nidulans involved in propionyl‐CoA detoxification
Fleck, C. B., & Brock, M. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06180.x · Cited by 40 · see citing works
“2), which display 53% and 50% identity to the yeast acetate transporter Ady2p, which was shown to be essential for the active uptake of acetate (Paiva et al., 2004) and may also be able to transport propionate.”
Background
Characterization of low-acetic-acid-producing yeast isolated from 2-deoxyglucose-resistant mutants and its application to high-gravity brewing
Mizuno, A., Tabei, H., & Iwahuti, M. (2006) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.101.31 · Cited by 40 · see citing works
Identification and application of keto acids transporters in Yarrowia lipolytica
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Yeast as a Tool to Study Signaling Pathways in Mitochondrial Stress Response and Cytoprotection
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“…such as phosphatidylserine externalization to the outer layer of the cytoplasmic membrane, DNA fragmentation, chromatin condensation, ROS production, and involvement of specific pro-apoptotic proteins, including cyt c, Aif1p, and Bcl-2 homology domain 3- (BH3-) containing protein [31–33].”
AcpA, a member of the GPR1/FUN34/YaaH membrane protein family, is essential for acetate permease activity in the hyphal fungus Aspergillus nidulans
Robellet, X., Flipphi, M. J. A., Pégot, S., MacCabe, A., & Vélot, C. (2008) · Biochemical Journal · doi:10.1042/bj20080124 · Cited by 38 · see citing works
Excessive by-product formation: A key contributor to low isobutanol yields of engineered Saccharomyces cerevisiae strains
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“In S. cerevisiae, export of carboxylic acids remains a poorly understood subject, as exemplified by the fact that even export of simple organic acids such as acetic acid and lactic acid remain incompletely understood (Casal et al., 2008; Paiva et al., 2004; van Maris et al., 2004b).”
Background
Osmoadaptation of wine yeast (Saccharomyces cerevisiae) during Icewine fermentation leads to high levels of acetic acid
Heit, C., Martin, S., Yang, F., & Inglis, D. L. (2018) · Journal of Applied Microbiology · doi:10.1111/jam.13733 · Cited by 35 · see citing works
“ADY2 encodes for a protein that has been proposed to function as an acetate permease (Paiva et al. 2004).”
Background
Transcriptome sequencing of Mycosphaerella fijiensis during association with Musa acuminata reveals candidate pathogenicity genes
Noar, R. D., & Daub, M. E. (2016) · BMC Genomics · doi:10.1186/s12864-016-3031-5 · Cited by 35 · see citing works
“in the environment was determined and is indicated in the bar chart [112–123].”
Background
Modulation of acetate utilization in Komagataella phaffii by metabolic engineering of tolerance and metabolism
Xu, Q. L., Bai, C., Liu, Y., Song, L., Tian, L., Yan, Y., Zhou, J., Zhou, X., Zhang, Y., & Cai, M. (2019) · Biotechnology for Biofuels · doi:10.1186/s13068-019-1404-0 · Cited by 33 · see citing works
A CRISPR/Cas9-based exploration into the elusive mechanism for lactate export in Saccharomyces cerevisiae
Mans, R., Hassing, E.-J., Wijsman, M., Giezekamp, A., Pronk, J. T., Daran, J.-M. G., & van Maris, A. J. A. (2017) · FEMS Yeast Research · doi:10.1093/femsyr/fox085 · Cited by 32 · see citing works
“…major facilitator superfamily (MFS) lactate transporter Jen1 and the acetate transporter Ady2 (Cássio, Leao and Van Uden 1987; Casal et al. 1999; Paiva et al. 2004; Ramos, Sychrová and Kschischo 2016) and combined deletion of JEN1 and ADY2 eliminates growth on lactate as the sole carbon source…”
Background
A substrate translocation trajectory in a cytoplasm‐facing topological model of the monocarboxylate/H+ symporter Jen1p
Soares‐Silva, I., Sá‐Pessoa, J., Myrianthopoulos, V., Mikros, E., Casal, M., & Diallinas, G. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07729.x · Cited by 32 · see citing works
“, 1999) and another by the ADY2 gene (Paiva et al., 2004).”
Background
Biological Demalication and Deacetification of Musts and Wines: Can Wine Yeasts Make the Wine Taste Better?
Vilela, A. (2017) · Fermentation · doi:10.3390/fermentation3040051 · Cited by 31 · see citing works
“Later, it was found that the protein Ady2p was vital for acetate transport in acetic acid-grown cells [63].”
Background
The physiological effect of heavy metals and volatile fatty acids on Methanococcus maripaludis S2
Abdel Azim, A., Rittmann, S. K.-M. R., Fino, D., & Bochmann, G. (2018) · Biotechnology for Biofuels · doi:10.1186/s13068-018-1302-x · Cited by 30 · see citing works
Experimental evidence of an acetate transporter protein and characterization of acetate activation in aceticlastic methanogenesis ofMethanosarcina mazei
Welte, C. U., Kröninger, L., & Deppenmeier, U. (2014) · FEMS Microbiology Letters · doi:10.1111/1574-6968.12550 · Cited by 30 · see citing works
Carboxylic Acid Transporters in Candida Pathogenesis
Alves, R. M. A., Sousa-Silva, M., Vieira, D., Soares, P. A., Chebaro, Y., Lorenz, M. C., Casal, M., Soares‐Silva, I., & Paiva, S. (2020) · mBio · doi:10.1128/mbio.00156-20 · Cited by 28 · see citing works
“cerevisiae, Ady2 has been identified as an acetate permease with the ability to transport other monocarboxylates, such as propionate, formate, and lactate (18, 36).”
Background
Expression and specificity profile of the major acetate transporter AcpA in Aspergillus nidulans
Sá‐Pessoa, J., Amillis, S., Casal, M., & Diallinas, G. (2015) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2015.02.010 · Cited by 26 · see citing works
“The orthologue of AcpA in the yeast Saccharomyces cerevisiae is Ady2p, which is responsible for the uptake of acetate, propionate and formate in symport with protons (Casal et al., 1996; Paiva et al., 2004; Pacheco et al., 2012).”
Background
Failure to Maintain Acetate Homeostasis by Acetate-Activating Enzymes Impacts Plant Development
Fu, X., Yang, H., Pangestu, F., & Nikolau, B. J. (2019) · PLANT PHYSIOLOGY · doi:10.1104/pp.19.01162 · Cited by 28 · see citing works
“Monocarboxylate transporters that can facilitate the translocation of acetate have been commonly found in bacteria, yeast, and mammals (Paiva et al., 2004; Moschen et al., 2012; Sun et al., 2018), and the Arabidopsis ABC transporter COMATOSE (CTS) has been invoked in the transport of acetate into…”
Background
Nsf1/Ypl230w participates in transcriptional activation during non-fermentative growth and in response to salt stress in Saccharomyces cerevisiae
Hlynialuk, C. J. W., Schierholtz, R., Vernooy, A., & van der Merwe, G. K. (2008) · Microbiology · doi:10.1099/mic.0.2008/019976-0 · Cited by 28 · see citing works
“We further analysed the effect of NSF1 deletion on the transcription of ADY2, which encodes the acetate permease of S. cerevisiae and is transcriptionally repressed by glucose, but activated by non-fermentable carbon sources, specifically acetate (Paiva et al., 2004).”
Background
Magnesium ions in yeast: setting free the metabolism from glucose catabolite repression
de Souza, R. B., Silva, R. K., Ferreira, D. S., Paiva, S. D. S. L., Pita, W. D. B., & de Morais, M. A. (2016) · Metallomics · doi:10.1039/c6mt00157b · Cited by 27 · see citing works
The acetate uptake transporter family motif “NPAPLGL(M/S)” is essential for substrate uptake
Ribas, D. M. N., Soares‐Silva, I., Vieira, D., Sousa-Silva, M., Sá‐Pessoa, J., Azevedo‐Silva, J., Viegas, S. C., Arraiano, C. M., Diallinas, G., Paiva, S., et al. (2018) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2018.10.001 · Cited by 27 · see citing works
Adaptive laboratory evolution under acetic acid stress enhances the multistress tolerance and ethanol production efficiency of Pichia kudriavzevii from lignocellulosic biomass
Dolpatcha, S., Phong, H. X., Thanonkeo, P., Klanrit, P., Yamada, M. C., & Thanonkeo, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-48408-7 · Cited by 26 · see citing works
“In S. cerevisiae , tolerance to acetic acid is also correlated with the expression of these three genes 97,98 as well as other genes, including ASG1 (encoding transcriptional regulator), ADH3 (encoding alcohol dehydrogenase), SKS1 (encoding protein kinase), and GIS4 (encoding a protein involved in…”
Background
Role of the DHH1 Gene in the Regulation of Monocarboxylic Acids Transporters Expression in Saccharomyces cerevisiae
Mota, S. M. D. S., Vieira, N., Barbosa, S., Delaveau, T., Torchet, C., Saux, A. L., Garcia, M., Pereira, A. M. M. B., Lemoine, S., Coulpier, F., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111589 · Cited by 26 · see citing works
Association of putative ammonium exporters Ato with detergent-resistant compartments of plasma membrane during yeast colony development: pH affects Ato1p localisation in patches
Řičicová, M., Kučerová, H., Váchová, L., & Palková, Z. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.02.011 · Cited by 25 · see citing works
Characterization of the GPR1/FUN34/YaaH protein family in the green microalga Chlamydomonas suggests their role as intracellular membrane acetate channels
Durante, L., Hübner, W., Lauersen, K. J., & Remacle, C. (2019) · Plant Direct · doi:10.1002/pld3.148 · Cited by 25 · see citing works
Advancing Functional Genetics Through Agrobacterium -Mediated Insertional Mutagenesis and CRISPR/Cas9 in the Commensal and Pathogenic Yeast Malassezia
Ianiri, G., Dagotto, G., Sun, S., & Heitman, J. (2019) · Genetics · doi:10.1534/genetics.119.302329 · Cited by 25 · see citing works
Laboratory evolution of new lactate transporter genes in a jen1Δ mutant of Saccharomyces cerevisiae and their identification as ADY2 alleles by whole-genome resequencing and transcriptome analysis
de Kok, S., Nijkamp, J. F., Oud, B., Roque, F. C., de Ridder, D., Daran, J.-M. G., Pronk, J. T., & van Maris, A. J. A. (2012) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2012.00787.x · Cited by 25 · see citing works
Deletion of JEN1 and ADY2 reduces lactic acid yield from an engineered Saccharomyces cerevisiae, in xylose medium, expressing a heterologous lactate dehydrogenase
Turner, T. L., Lane, S., Jayakody, L. N., Zhang, G.-C., Kim, H., Cho, W., & Jin, Y. (2019) · FEMS Yeast Research · doi:10.1093/femsyr/foz050 · Cited by 23 · see citing works
Functional analysis of Kluyveromyces lactis carboxylic acids permeases: heterologous expression of KlJEN1 and KlJEN2 genes
Queirós, O., Pereira, L., Paiva, S., Moradas‐Ferreira, P., & Casal, M. (2006) · Current Genetics · doi:10.1007/s00294-006-0107-9 · Cited by 24 · see citing works
“Recently, the gene ADY2 was reported as a new key element in the mechanism of transport of acetic acid in S. cerevisiae (Paiva et al. 2004).”
Background
Acetate Regulation of Spore Formation Is under the Control of the Ras/Cyclic AMP/Protein Kinase A Pathway and Carbon Dioxide in Saccharomyces cerevisiae
Jungbluth, M., Mösch, H., & Taxis, C. (2012) · Eukaryotic Cell · doi:10.1128/ec.05240-11 · Cited by 24 · see citing works
“Ady1 is important for the localization of Mpc54 to SPBs and the formation of MPs (11), whereas Ady2 is important for acetate uptake (44) and MP component production (57).”
Background
Lack of Ach1 CoA-Transferase Triggers Apoptosis and Decreases Chronological Lifespan in Yeast
Orlandi, I., Casatta, N., & Vai, M. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00067 · Cited by 23 · see citing works
“This work was supported by FAR 2010 to Marina Vai.”
BackgroundMethod
Assessing physio-macromolecular effects of lactic acid onZygosaccharomyces bailiicells during microaerobic fermentation
Kuanyshev, N., Ami, D., Signori, L., Porro, D., Morrissey, J. P., & Branduardi, P. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow058 · Cited by 23 · see citing works
“The mechanism of acetic acid toxicity, model organic acid for stress response studies, has been extensively studied in the yeast S. cerevisiae (Paiva et al. 2004; Mira, Teixeira and Sa 2010; Nygård et al. 2014).”
Background
Evolutionary Adaptation by Repetitive Long-Term Cultivation with Gradual Increase in Temperature for Acquiring Multi-Stress Tolerance and High Ethanol Productivity in Kluyveromyces marxianus DMKU 3-1042
Pattanakittivorakul, S., Tsuzuno, T., Kosaka, T., Murata, M., Kanesaki, Y., Yoshikawa, H., Limtong, S., & Yamada, M. C. (2022) · Microorganisms · doi:10.3390/microorganisms10040798 · Cited by 22 · see citing works
Acetate provokes mitochondrial stress and cell death inUstilago maydis
Kretschmer, M., Lambie, S. C., Croll, D., & Kronstad, J. W. (2017) · Molecular Microbiology · doi:10.1111/mmi.13894 · Cited by 22 · see citing works
“cerevisiae, for example, acetate is not used as a carbon source if fermentable sugars are available, but it is taken up passively by the aquaporin Fps1 in the presence of glucose at low pH (Paiva et al., 2004; Mollapour and Piper, 2007).”
Background
Engineering Flocculation for Improved Tolerance and Production of d-Lactic Acid in Pichia pastoris
Sae-Tang, K., Bumrungtham, P., Mhuantong, W., Champreda, V., Tanapongpipat, S., Zhao, X., Liu, C., & Runguphan, W. (2023) · Journal of Fungi · doi:10.3390/jof9040409 · Cited by 19 · see citing works
Mathematical Modeling and Validation of the Ergosterol Pathway in Saccharomyces cerevisiae
Alvarez‐Vasquez, F., Riezman, H., Hannun, Y. A., & Voit, E. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028344 · Cited by 21 · see citing works
“cerevisiae represses expression of acetyl energy dependent transporters [117,118]; under these conditions, the uptake of acetate is proportional to the external acetate concentration [119,120].”
Background
Isolation and Characterization of Transposon-Insertional Mutants from Paenibacillus polymyxa E681 Altering the Biosynthesis of Indole-3-Acetic Acid
Phi, Q., Oh, S.-H., Park, Y.-M., Park, S., Ryu, C., & Ghim, S. (2008) · Current Microbiology · doi:10.1007/s00284-008-9118-8 · Cited by 20 · see citing works
“These proteins are predicted to be localized in the bacterial membrane involving transport and their function remains to be elucidated [4], whereas in yeasts and fungi this novel protein family has been demonstrated to be involved in ammonia secretion, acetate uptake, and the adaptation process to acetic acid [1, 4, 1…”
Background
Polygenic analysis of very high acetic acid tolerance in the yeast Saccharomyces cerevisiae reveals a complex genetic background and several new causative alleles
Stojiljković, M., Foulquié-Moreno, M. R., & Thevelein, J. M. (2020) · Biotechnology for Biofuels · doi:10.1186/s13068-020-01761-5 · Cited by 19 · see citing works
RNA sequencing reveals metabolic and regulatory changes leading to more robust fermentation performance during short-term adaptation of Saccharomyces cerevisiae to lignocellulosic inhibitors
Dijk, M., Rugbjerg, P., Nygård, Y., & Lisbeth Olsson, A. (2021) · Biotechnology for Biofuels · doi:10.1186/s13068-021-02049-y · Cited by 19 · see citing works
Characterization of the Metabolic Requirements in Yeast Meiosis
Ray, D., & Ye, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063707 · Cited by 19 · see citing works
“Reactions are compartmentalized in either the cytoplasm or the mitochondria, based on the sub-cellular localization of enzymes determined by experimental evidence [33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54].”
Mechanism and improvement of yeast tolerance to biomass-derived inhibitors: A review
Yu, J., Li, C., Cheng, Y. W., Guo, S., Lu, H., Xie, X., Ji, H., & Qiao, Y. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108562 · Cited by 18 · see citing works
Replacement of the initial steps of ethanol metabolism inSaccharomyces cerevisiaeby ATP-independent acetylating acetaldehyde dehydrogenase
Kozak, B. U., van Rossum, H. M., Niemeijer, M. S., Dijk, M., Benjamin, K. R., Wu, L., Daran, J.-M. G., Pronk, J. T., & van Maris, A. J. A. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow006 · Cited by 18 · see citing works
“ADY2, which encodes an acetic acid importer localized in the plasma-membrane (Paiva et al. 2004), was among the 14 genes on this region (Table S3, Supporting Information).”
Background
Mutations at different sites in members of the Gpr1/Fun34/YaaH protein family cause hypersensitivity to acetic acid inSaccharomyces cerevisiaeas well as inYarrowia lipolytica
Gentsch, M., Kuschel, M., Schlegel, S., & Barth, G. (2007) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00191.x · Cited by 18 · see citing works
“Data indicate that Ycr010cp (Ady2p) is essential for the mediated acetate uptake in S. cerevisiae (Paiva et al., 2004).”
Background
Functional analysis of alcS, a gene of the alc cluster in Aspergillus nidulans
Flipphi, M. J. A., Robellet, X., Dequier, E., Leschelle, X., Felenbok, B., & Vélot, C. (2006) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2005.12.008 · Cited by 18 · see citing works
The Fps1p aquaglyceroporin facilitates the use of small aliphatic amides as a nitrogen source by amidase-expressing yeasts
Shepherd, A., & Piper, P. W. (2010) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2010.00636.x · Cited by 17 · see citing works
“Loss of Fps1p elevates acetic acid resistance in Z. rouxii In its glucose-repressed state, S. cerevisiae cannot assimilate acetate as a carbon source (Casal et al., 1996; Paiva et al., 2004).”
Background
Genome-wide overexpression screen for sodium acetate resistance in Saccharomyces cerevisiae
Peña, P. V., Glasker, S., & Srienc, F. (2012) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2012.12.005 · Cited by 16 · see citing works
Yeast as a tool to express sugar acid transporters with biotechnological interest
Ribas, D. M. N., Sá‐Pessoa, J., Soares‐Silva, I., Paiva, S., Nygård, Y., Ruohonen, L., Penttilä, M. E., & Casal, M. (2017) · FEMS Yeast Research · doi:10.1093/femsyr/fox005 · Cited by 15 · see citing works

Ady2p is essential for the acetate permease activity in the yeast Saccharomyces cerevisiae. Yeast 21
Paiva, R., Devaux, F., Barbosa, S., Jacq, C., & Casal, M. (2004)
Deletion of acetate transporter gene ADY2 improved tolerance of Saccharomyces cerevisiae against multiple stresses and enhanced ethanol production in the presence of acetic acid
Zhang, M., Zhang, K., Mehmood, M. A., Zhao, Z. K., Bai, F., & Zhao, X. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.05.191 · Cited by 87 · see citing works
Ady2p is essential for the acetate pemease activity in the yeast Saccharomyces cerevisae
Paiva, S., Devaux, F., Barbosa, S., Jacq, C., & Casal, M. (2004) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Identification of an acetate-tolerant strain of Saccharomyces cerevisiae and characterization by gene expression analysis
Haitani, Y., Tanaka, K., Yamamoto, M., Nakamura, T., Ando, A., Ogawa, J., & Shima, J. (2012) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2012.07.002 · Cited by 28 · see citing works
Engineering the activity and specificity of Saccharomyces cerevisiae Acetate Transporter Ady2/Ato1
Rendulić, T., Alves, J., Soares‐Silva, I., Nevoigt, E., & Casal, M. (2021) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Authors: Paiva, S., Devaux, F., Barbosa, S., Jacq, C., & Casal, M.
Affiliations: University of Minho (PT)
Centre National de la Recherche Scientifique (FR)
ORCID: Paiva, Sandra
Casal, Margarida
Venue: Yeast
Publisher: Wiley
Published: 2004-02
Volume: 21
Issue: 3
Pages: 201-210
ISSN: 0749-503X (ISSN-L)
1097-0061
DOI: 10.1002/yea.1056
OpenAlex: W2000461833
Cited by: 154
References: 23
Citations by year: 2026: 4 · 2025: 8 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 17 · 2020: 5 · 2019: 11 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 5 · 2013: 6 · 2012: 14
FWCI: 2.13
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 9 d)
Locations: Yeast (publishedVersion)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords: acetate uptake, acetate transport, Saccharomyces cerevisiae, non-fermentable carbon sources, gene expression reprogramming, mitochondrial biogenesis, translation activation, membrane transporters
MeSH terms: Biological Transport, DNA, Fungal, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, Mutagenesis, Insertional, Acetic Acid, Oligonucleotide Array Sequence Analysis, Membrane Transport Proteins, Monocarboxylic Acid Transporters, Saccharomyces cerevisiae Proteins

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Ady2p is essential for the acetate permease activity in the yeast Saccharomyces cerevisiae

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