Cited by 200Fungal and yeast genetics researchBacterial Genetics and BiotechnologyDrug Transport and Resistance Mechanisms

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Mechanisms regulating the transport of acetic acid in Saccharomyces cerevisiae.

Casal, Margarida, Cardoso, Helena, Leao, Cecilia·1996·Microbiology

DOI 10.1099/13500872-142-6-1385

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Abstract

Cells of the yeast Saccharomyces cerevisiae IGC 4072 grown in medium with acetic acid produced a mediated transport system for acetic acid that behaved as an electroneutral proton symport for the anionic form of the acid. The system could transport propionate and formate but not lactate and pyruvate. Uptake of labelled lactic acid was negligible, no mediated transport system activity for this acid being found. The acetate transporter was also found in cells grown in lactic acid or ethanol media, suggesting that the carrier did not require the presence of an external inducer. When cells were grown in lactic acid medium, uptake of labelled acetic acid, at pH 5.0, was biphasic and consistent with the presence of two distinct transport modes for the acid. One of these components corresponded to the acetate/proton symport, and the higher affinity system corresponded to a more general monocarboxylate carrier that could also transport lactate, pyruvate and propionate. Both systems were subject to repression by glucose, fructose, sucrose, maltose or galactose. In glucose-repressed cells, the undissociated form of the acids appeared to be the only one that could cross the plasma membrane, a diffusion mechanism being involved in the acid uptake. Under these growth conditions and when the extracellular pH was lower than that of the cytosol, accumulation of the acid could also be observed, it being a function of the delta pH.

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Authors: Casal, M., Cardoso, H., & Leao, C.
Affiliations: University of Minho (PT)
Department of Biology, University of Minho, 4719 Braga Codex, Portugal
ORCID: Casal, Margarida
Venue: Microbiology
Publisher: Microbiology Society
Published: 1996-06-01
Volume: 142
Issue: 6
Pages: 1385-1390
ISSN: 1350-0872 (ISSN-L)
1465-2080
DOI: 10.1099/13500872-142-6-1385
OpenAlex: W2115422703
Cited by: 200
References: 17
Citations by year: 2026: 4 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 14 · 2020: 9 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 8 · 2015: 11 · 2014: 6 · 2013: 8 · 2012: 10
FWCI: 1.40
Type: journal article
Language: en
Open access: closed
Locations: Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Johns Hopkins University
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: Saccharomyces cerevisiae, proton symport, glucose repression, lactate utilization, pyruvate uptake, pH gradient, acid accumulation
MeSH terms: Acetates, Biological Transport, Carbohydrates, Carrier Proteins, Diffusion, Formates, Fungal Proteins, Lactates, Propionates, Protons, Pyruvates, Saccharomyces cerevisiae, Pyruvic Acid, Acetic Acid, Lactic Acid, Monocarboxylic Acid Transporters

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Mechanisms regulating the transport of acetic acid in Saccharomyces cerevisiae.

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