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Candida albicans drug resistance—Another way to cope with stress
Abstract
There are relatively few classes of antifungal drugs. This restricts clinicians' therapeutic choices and these choices are further reduced by the emergence of drug resistance. Exposure to antifungal drugs represents an environmental stress for the fungal pathogen Candida albicans. The immediate response of C. albicans to antifungals may be drug tolerance, which can lead to drug resistance. This article examines C. albicans drug resistance from the perspective of it being a stress response and investigates how commonality with other stress-response pathways gives insights into the prospects for overcoming, or preventing, drug resistance.
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“However, iron limitation increased the susceptibility of dispersed daughter cells from biofilms to amphotericin B, detected by a number of cells which induce responses by signalling pathways [162].”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [162]
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Metadata
- Authors
- Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Tanabe, K., Niimi, M., & Monk, B. C.
- Affiliations
- University of Otago (NZ)
- National Institute of Infectious Diseases (JP)
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 2007-10-01
- Volume
- 153
- Issue
- 10
- Pages
- 3211-3217
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2093997770
- Cited by
- 208
- References
- 46
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 9 · 2022: 3 · 2021: 17 · 2020: 10 · 2019: 16 · 2018: 13 · 2017: 15 · 2016: 13 · 2015: 9 · 2014: 19 · 2013: 19 · 2012: 10
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Health Sciences Foundation
- National Institutes of Health
- National Institute of Dental and Craniofacial Research (R01DE016885)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
- Keywords
- Candida albicans, antifungal resistance, drug tolerance, stress response, environmental stress, antifungal agents, stress response pathways, fungal pathogens
- MeSH terms
- Animals, Antifungal Agents, Candida albicans, Candidiasis, Humans, Drug Resistance, Fungal
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