Candida glabrata: A review of its features and resistance

Rodrigues, C. F.; Silva, S.; Henriques, M.

doi:10.1007/s10096-013-2009-3

Cited by 269Antifungal resistance and susceptibilityFungal and yeast genetics researchYeasts and Rust Fungi Studies

Candida glabrata: A review of its features and resistance

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Rodrigues, C. F., Silva, S., Henriques, M.·2014·European Journal of Clinical Microbiology & Infectious Diseases

DOI 10.1007/s10096-013-2009-3

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Abstract

Candida species belong to the normal microbiota of the oral cavity and gastrointestinal and vaginal tracts, and are responsible for several clinical manifestations, from mucocutaneous overgrowth to bloodstream infections. Once believed to be non-pathogenic, Candida glabrata was rapidly blamable for many human diseases. Year after year, these pathological circumstances are more recurrent and problematic to treat, especially when patients reveal any level of immunosuppression. These difficulties arise from the capacity of C. glabrata to form biofilms and also from its high resistance to traditional antifungal therapies. Thus, this review intends to present an excerpt of the biology, epidemiology, and pathology of C. glabrata, and detail an approach to its resistance mechanisms based on studies carried out up to the present.

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The first step of Candida glabrata biofilm development is adhesion and/or colonisation of yeast cells to an abiotic and/or biotic surface.
“The first step of C. glabrata biofilm development is adhesion and/or colonisation of yeast cells to an abiotic or/and biotic surface [4,10].”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [10]
Candida glabrata has high antifungal drug resistance.
“In addition to the high antifungal drugs resistance and inability to form hyphae or secret hydrolases, C. glabrata retain many virulence factors”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [10]
Candida glabrata retains many virulence factors that contribute to its extreme aggressiveness.
“C. glabrata retain many virulence factors that contribute to its extreme aggressiveness and result in a low therapeutic response and serious recurrent candidiasis”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [10]
Biofilms are very resistant to antifungal treatments.
“For their extraordinary organization, especially regarding the complex structure of the matrix, biofilms are very resistant to antifungal treatments.”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [10]
Biofilm formation ability is a virulence factor of Candida glabrata.
“particularly biofilm formation ability”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [10]

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Candida glabrata , an emerging fungal pathogen, exhibits superior relative cell surface hydrophobicity and adhesion to denture acrylic surfaces compared with Candida albicans
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A Nonsense Mutation in the ERG6 Gene Leads to Reduced Susceptibility to Polyenes in a Clinical Isolate of Candida glabrata
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The bZip transcription factor Cgap1p is involved in multidrug resistance and required for activation of multidrug transporter gene CgFLR1 in Candida glabrata
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Regulation of Candida glabrata oxidative stress resistance is adapted to host environment
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Regulation of the CgPdr1 Transcription Factor from the Pathogen Candida glabrata
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Proteomics of drug resistance in Candida glabrata biofilms
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Mss11p Is a Central Element of the Regulatory Network That Controls FLO11 Expression and Invasive Growth in Saccharomyces cerevisiae
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Candida glabrata STE12 is required for wild‐type levels of virulence and nitrogen starvation induced filamentation
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Fungal Infections in Solid Organ Transplant Patients
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Gain-of-Function Mutations in PDR1 , a Regulator of Antifungal Drug Resistance in Candida glabrata, Control Adherence to Host Cells
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Disruption of the Human Pathogenic Yeast Candida albicans Catalase Gene Decreases Survival in Mouse‐Model Infection and Elevates Susceptibility to Higher Temperature and to Detergents
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Assessment of Candida glabrata Strain Relatedness by Pulsed-Field Gel Electrophoresis and Multilocus Sequence Typing
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Pathogenesis and Antifungal Drug Resistance of the Human Fungal Pathogen Candida glabrata
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Skn7p is involved in oxidative stress response and virulence of Candida glabrata
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Hydrolytic Enzyme Production is Associated with Candida Albicans Biofilm Formation from Patients with Type 1 Diabetes
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Identification and differential gene expression of adhesin-like wall proteins in Candida glabrata biofilms
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Megasatellites: A peculiar class of giant minisatellites in genes involved in cell adhesion and pathogenicity in Candida glabrata
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New regulators of biofilm development in Candida glabrata
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Yeast vaginitis during pregnancy: susceptibility testing of 13 antifungal drugs and boric acid and the detection of four virulence factors
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STB5 Is a Negative Regulator of Azole Resistance in Candida glabrata
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Reverse transcriptase polymerase chain reaction (RT‐PCR) detection of HLP gene expression in Candida glabrata and its possible role in in vitro haemolysin production
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Differential Oxidant Tolerance Determined by the Key Transcription Factor Yap1 Is Controlled by Levels of the Yap1-binding Protein, Ybp1
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Gross karyotypic and phenotypic alterations among different progenies of the Candida glabrata CBS138/ATCC2001 reference strain
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Candida glabrata tryptophan‐based pigment production via the Ehrlich pathway
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The NDR/LATS Kinase Cbk1 Controls the Activity of the Transcriptional Regulator Bcr1 during Biofilm Formation in Candida albicans
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Karyotyping of Candida albicans and Candida glabrata from patients with Candida sepsis
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Respiration of medically importantCandidaspecies andSaccharomyces cerevisiaein relation to glucose effect
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Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome
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Extensive chromosome rearrangements distinguish the karyotype of the hypovirulent species Candida dubliniensis from the virulent Candida albicans
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The inositol regulon controls viability in Candida glabrata
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Roles of Cellular Respiration, Cg CDR1 , and Cg CDR2 in Candida glabrata Resistance to Histatin 5
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Torulopsis glabrata an emerging yeast pathogen in cancer patients
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Candida sp. Infections in Patients with Diabetes Mellitus
Rodrigues, C. F., Rodrigues, M. E., & Henriques, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8010076 · Cited by 337 · see citing works
Self-citation
Yeast diversity of sourdoughs and associated metabolic properties and functionalities
Vuyst, L. D., Harth, H., Kerrebroeck, S. V., & Leroy, F. (2016) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2016.07.018 · Cited by 306 · see citing works
Candida Species Biofilms’ Antifungal Resistance
Silva, S. M., Rodrigues, C. F., Araújo, D., Rodrigues, M. E., & Henriques, M. (2017) · Journal of Fungi · doi:10.3390/jof3010008 · Cited by 308 · see citing works
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New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics
Geddes‐McAlister, J., & Shapiro, R. S. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13739 · Cited by 159 · see citing works
Drug-ResistantCandida glabrataInfection in Cancer Patients
Farmakiotis, D., Tarrand, J. J., & Kontoyiannis, D. P. (2014) · Emerging Infectious Diseases · doi:10.3201/eid2011.140685 · Cited by 152 · see citing works
Candida spp./Bacteria Mixed Biofilms
Rodrigues, M. E., Gomes, F., & Rodrigues, C. F. (2019) · Journal of Fungi · doi:10.3390/jof6010005 · Cited by 149 · see citing works
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Biofilms and vulvovaginal candidiasis
Rodríguez‐Cerdeira, C., Carnero-Gregorio, M., Molares-Vila, A., López-Bárcenas, A., Fabbrocini, G., Bardhi, B., Sinani, A., Sánchez-Blanco, E., Arenas, R., & Hernández‐Castro, R. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.11.011 · Cited by 154 · see citing works
Use of RNA-Protein Complexes for Genome Editing in Non- albicans Candida Species
Grahl, N., Demers, E. G., Crocker, A. W., & Hogan, D. A. (2017) · mSphere · doi:10.1128/msphere.00218-17 · Cited by 133 · see citing works
Candida glabrata Biofilms: How Far Have We Come?
Rodrigues, C., Rodrigues, M., Silva, S., & Henriques, M. (2017) · Journal of Fungi · doi:10.3390/jof3010011 · Cited by 129 · see citing works
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Deep learning approach to describe and classify fungi microscopic images
Zieliński, B., Sroka-Oleksiak, A., Rymarczyk, D., Piekarczyk, A., & Brzychczy-Włoch, M. (2020) · PLOS ONE · doi:10.1371/journal.pone.0234806 · Cited by 126 · see citing works
Hog1 regulates stress tolerance and virulence in the emerging fungal pathogen Candida auris
Day, A. M., McNiff, M. M., da Silva Dantas, A., Gow, N. A. R., & Quinn, J. (2018) · mSphere · doi:10.1128/msphere.00506-18 · Cited by 116 · see citing works
Characterization of oral candidiasis and the Candida species profile in patients with oral mucosal diseases
Hu, L., He, C. H., Chen, Z., Chen, X., Hua, H., & Yan, Z. (2019) · Microbial Pathogenesis · doi:10.1016/j.micpath.2019.103575 · Cited by 116 · see citing works
Prevalence of biofilms in Candida spp. bloodstream infections: A meta-analysis
Atiencia-Carrera, M. B., Cabezas-Mera, F. S., Tejera, E., & Machado, A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263522 · Cited by 112 · see citing works
Divergent Approaches to Virulence in C. albicans and C. glabrata: Two Sides of the Same Coin
Galocha, M., Pais, P., Cavalheiro, M., Pereira, D., Viana, R., & Teixeira, M. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092345 · Cited by 105 · see citing works
The birth of a deadly yeast: tracing the evolutionary emergence of virulence traits in Candida glabrata
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Pan-Echinocandin-Resistant Candida glabrata Bloodstream Infection Complicating COVID-19: A Fatal Case Report
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In vitro antimicrobial effects of Hypoxis hemerocallidea against six pathogens with dermatological relevance and its phytochemical characterization and cytotoxicity evaluation
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Adjuvant antifungal therapy using tissue tolerable plasma on oral mucosa and removable dentures in oral candidiasis patients: a randomised double‐blinded split‐mouth pilot study
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Antifungal Resistance in Clinical Isolates of Candida glabrata in Ibero-America
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Synthesis andIn VitroEvaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents
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Decreasing Cell Population of Individual Candida Species Does Not Impair the Virulence of Candida albicans and Candida glabrata Mixed Biofilms
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A new inducible CRISPR‐Cas9 system useful for genome editing and study of double‐strand break repair in Candida glabrata
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The evaluation of the overexpression of theERG‐11,MDR‐1,CDR‐1, andCDR‐2genes in fluconazole‐resistantCandida albicansisolated from Ahvazian cancer patients with oral candidiasis
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Competition ofCandida glabrataagainstLactobacillusis Hog1 dependent
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The phosphoinositide 3-kinase regulates retrograde trafficking of the iron permease CgFtr1 and iron homeostasis in Candida glabrata
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Comparison of genome engineering using the CRISPR-Cas9 system in C. glabrata wild-type and lig4 strains
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Microbial Interactions and Immunity Response in Oral Candida Species
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The involvement of the Candida glabrata trehalase enzymes in stress resistance and gut colonization
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Effect of Cold Atmospheric Plasma Jet Associated to Polyene Antifungals on Candida albicans Biofilms
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Erg6p is essential for antifungal drug resistance, plasma membrane properties and cell wall integrity in Candida glabrata
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Repeated applications of photodynamic therapy on Candida glabrata biofilms formed in acrylic resin polymerized
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Fluorescent Tracking of Yeast Division Clarifies the Essential Role of Spleen Tyrosine Kinase in the Intracellular Control of Candida glabrata in Macrophages
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REVIEW Candida glabrata: a review of its features and resistance
Rodrigues, C. F., Silva, S., & Henriques, M. (2013)
Self-citation
Candida glabrata: an important fungal pathogen for the 21st century
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Candida glabrata Biofilms: How Far Have We Come?
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Self-citation
Candida glabrata: un patógeno emergente
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Authors: Rodrigues, C. F., Silva, S., & Henriques, M.
Affiliations: Institute for Biotechnology and Bioengineering (PT)
Corresponding author: Henriques, M.
ORCID: Rodrigues, C. F.
Silva, S.
Henriques, M.
Venue: European Journal of Clinical Microbiology & Infectious Diseases
Publisher: Springer Science and Business Media LLC
Published: 2013-11-19
Volume: 33
Issue: 5
Pages: 673-688
ISSN: 0934-9723 (ISSN-L)
1435-4373
DOI: 10.1007/s10096-013-2009-3
OpenAlex: W2099290964
Cited by: 268
References: 155
Citations by year: 2026: 11 · 2025: 10 · 2024: 23 · 2023: 17 · 2022: 25 · 2021: 28 · 2020: 27 · 2019: 24 · 2018: 34 · 2017: 24 · 2016: 19 · 2015: 16 · 2014: 10
FWCI: 1.95
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords: Candida glabrata, antifungal resistance, biofilm, candidiasis, bloodstream infection, immunosuppression, fungal pathogenesis, yeast biology
MeSH terms: Antifungal Agents, Candidiasis, Humans, Drug Resistance, Fungal, Candida glabrata

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Candida glabrata: A review of its features and resistance

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