Proteomics of drug resistance in Candida glabrata biofilms
Abstract
Candida glabrata is a fungal pathogen that causes a variety of mucosal and systemic infections among compromised patient populations with higher mortality rates. Previous studies have shown that biofilm mode of the growth of the fungus is highly resistant to antifungal agents compared with the free-floating or planktonic mode of growth. Therefore, in the present study, we used 2-D DIGE to evaluate the differential proteomic profiles of C. glabrata under planktonic and biofilm modes of growth. Candida glabrata biofilms were developed on polystyrene surfaces and age-matched planktonic cultures were obtained in parallel. Initially, biofilm architecture, viability, and antifungal susceptibility were evaluated. Differentially expressed proteins more than 1.5-fold in DIGE analysis were subjected to MS/MS. The transcriptomic regulation of these biomarkers was evaluated by quantitative real-time PCR. Candida glabrata biofilms were highly resistant to the antifungals and biocides compared with the planktonic mode of growth. Candida glabrata biofilm proteome when compared with its planktonic proteome showed upregulation of stress response proteins, while glycolysis enzymes were downregulated. Similar trend could be observed at transcriptomic level. In conclusion, C. glabrata biofilms possess higher amount of stress response proteins, which may potentially contribute to the higher antifungal resistance seen in C. glabrata biofilms.
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Upregulation of Trx1p as a stress-response protein exerts defences to C. glabrata against oxidative stress.
“Furthermore, the upregulation of Trx1p as a stress-response protein exerts defences to C. glabrata against oxidative stress [72].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [72]
Stressed C. glabrata biofilms show a positive regulatory protein response associated with the stress response, including heat shock and other stress proteins Hsp12, Trx1, and Pep4.
“Seneviratne et al. [163] showed that there is a positive regulatory protein response associated with the stress response in biofilms of stressed C. glabrata, as displayed by the heat shock and other stress proteins (Hsp12, Trx1, and Pep4).”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [163]
Cites
A new mathematical model for relative quantification in real-time RT-PCR
Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610 · see citing works
Costerton, J. W., Lewandowski, Z., Caldwell, D. E., Korber, D. R., & Lappin-Scott, H. M. (1995) · Annual Review of Microbiology · doi:10.1146/annurev.mi.49.100195.003431 · Cited by 4,718 · see citing works
Thioredoxin-dependent peroxide reductase from yeast.
Chae, H. Z., Chung, S., & Rhee, S. G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47038-x · Cited by 960 · see citing works
Ramage, G., Vande Walle, K., Wickes, B. L., & López-Ribot, J. L. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.9.2475-2479.2001 · Cited by 753 · see citing works
Yan, J. X., Wait, R., Berkelman, T., Harry, R. A., Westbrook, J. A., Wheeler, C., & Dunn, M. J. (2000) · Electrophoresis · doi:10.1002/1522-2683(200011)21:17 · Cited by 705 · see citing works
<i>Candida</i>Biofilms: an Update
Ramage, G., Saville, S. P., Thomas, D. P., & López-Ribot, J. L. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.4.633-638.2005 · Cited by 678 · see citing works
Trick, W. E., Fridkin, S. K., Edwards, J. R., Hajjeh, R. A., Gaynes, R. P., & Hospitals, T. N. N. I. S. S. (2002) · Clinical Infectious Diseases · doi:10.1086/342300 · Cited by 660 · see citing works
Antifungal Resistance of Candidal Biofilms Formed on Denture Acrylic in vitro
Chandra, J., Mukherjee, P. K., Leidich, S. D., Faddoul, F., Hoyer, L. L., Douglas, L., & Ghannoum, M. A. (2001) · Journal of Dental Research · doi:10.1177/00220345010800031101 · Cited by 588 · see citing works
Forging a Link Between Biofilms and Disease
Potera, C. (1999) · Science · doi:10.1126/science.283.5409.1837 · Cited by 550 · see citing works
<i>Candida albicans</i> Biofilms Produce Antifungal-Tolerant Persister Cells
LaFleur, M. D., Kumamoto, C. A., & Lewis, K. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00684-06 · Cited by 521 · see citing works
Tumbarello, M., Posteraro, B., Trecarichi, E. M., Fiori, B., Rossi, M., Porta, R., de Gaetano Donati, K., La Sorda, M., Spanu, T., Fadda, G., et al. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.00131-07 · Cited by 343 · see citing works
Genetics and genomics of Candida albicans biofilm formation
Nobile, C. J., & Mitchell, A. P. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00761.x · Cited by 281 · see citing works
Biofilm formation of Candida albicans is variably affected by saliva and dietary sugars
Jin, Y., Samaranayake, L. P., Samaranayake, Y. H., & Yip, H. K. (2004) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2004.04.011 · Cited by 266 · see citing works
Self-citationThe MAP kinase signal transduction network in Candida albicans
Alonso‐Monge, R., Román, E., Nombela, C., & Plá, J. (2006) · Microbiology · doi:10.1099/mic.0.28616-0 · Cited by 263 · see citing works
Jin, Y., Yip, H. K., Samaranayake, Y. H., Yau, J. Y. Y., & Samaranayake, L. P. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.7.2961-2967.2003 · Cited by 254 · see citing works
Self-citationCandida glabrata , an Emerging Oral Opportunistic Pathogen
Li, L., Redding, S. W., & Dongari‐Bagtzoglou, A. I. (2007) · Journal of Dental Research · doi:10.1177/154405910708600304 · Cited by 238 · see citing works
Candida albicans drug resistance—Another way to cope with stress
Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Tanabe, K., Niimi, M., & Monk, B. C. (2007) · Microbiology · doi:10.1099/mic.0.2007/010405-0 · Cited by 208 · see citing works
Karababa, M., Coste, A. T., Rognon, B., Billé, J., & Sanglard, D. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.8.3064-3079.2004 · Cited by 161 · see citing works
Chauhan, N., Inglis, D., Roman, E., Pla, J., Li, D., Calera, J. A., & Calderone, R. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.5.1018-1024.2003 · Cited by 159 · see citing works
Infection-related gene expression in Candida albicans
Brown, A. J. P., Odds, F. C., & Gow, N. A. R. (2007) · Current Opinion in Microbiology · doi:10.1016/j.mib.2007.04.001 · Cited by 148 · see citing works
Trotter, E. W., & Grant, C. M. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03216.x · Cited by 146 · see citing works
Mukherjee, P. K., Mohamed, S., Chandra, J., Kuhn, D. M., Liu, S., Antar, O. S., Munyon, R., Mitchell, A. P., Andes, D. R., Chance, M. R., et al. (2006) · Infection and Immunity · doi:10.1128/iai.00161-06 · Cited by 143 · see citing works
Temporal analysis of Candida albicans gene expression during biofilm development
Yeater, K. M., Chandra, J., Cheng, G., Mukherjee, P. K., Zhao, X., Rodriguez‐Zas, S. L., Kwast, K. E., Ghannoum, M. A., & Hoyer, L. L. (2007) · Microbiology · doi:10.1099/mic.0.2007/006163-0 · Cited by 138 · see citing works
Thein, Z. M., Samaranayake, Y. H., & Samaranayake, L. P. (2007) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2007.01.009 · Cited by 133 · see citing works
Self-citationBiofilm Formation by and Antifungal Susceptibility of Candida Isolates from Urine
Jain, N., Kohli, R., Cook, E., Gialanella, P., Chang, T., & Fries, B. C. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02439-06 · Cited by 129 · see citing works
Götz, R., Gnann, A., & Zimmermann, F. K. (1999) · Yeast · doi:10.1002/(sici)1097-0061(199907)15:10a · Cited by 124 · see citing works
Seneviratne, C. J., da Silva, W. J., Jin, L., Samaranayake, Y. H., & Samaranayake, L. P. (2009) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2009.08.002 · Cited by 120 · see citing works
Self-citationProteomics for the analysis of the <b><i>Candida albicans</i></b> biofilm lifestyle
Thomas, D. P., Bachmann, S. P., & Lopez‐Ribot, J. L. (2006) · PROTEOMICS · doi:10.1002/pmic.200600332 · Cited by 117 · see citing works
Candida albicans Biofilms: More Than Filamentation
Lopez-Ribot, J. L. (2005) · Current Biology · doi:10.1016/j.cub.2005.06.020 · Cited by 116 · see citing works
Cell Density and Cell Aging as Factors Modulating Antifungal Resistance ofCandida albicansBiofilms
Seneviratne, C. J., Jin, L., Samaranayake, Y. H., & Samaranayake, L. P. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00541-08 · Cited by 107 · see citing works
Self-citationSeneviratne, C. J., Wang, Y., Jin, L., Abiko, Y., & Samaranayake, L. P. (2008) · PROTEOMICS · doi:10.1002/pmic.200701097 · Cited by 104 · see citing works
Self-citationMartínez‐Gomariz, M., Perumal, P., Mekala, S., Nombela, C., Chaffin, W. L., & Gil, C. (2009) · PROTEOMICS · doi:10.1002/pmic.200700594 · Cited by 101 · see citing works
Antibacterial properties of root canal sealers, cements and pastes
Ørstavik, D. (1981) · International Endodontic Journal · doi:10.1111/j.1365-2591.1981.tb01073.x · Cited by 100 · see citing works
Absence of Amphotericin B-Tolerant Persister Cells in Biofilms of Some <i>Candida</i> Species
Al-Dhaheri, R. S., & Douglas, L. J. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01473-07 · Cited by 99 · see citing works
Lewis, R. E., Kontoyiannis, D. P., Darouiche, R. O., RAAD, I. I., & Prince, R. A. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.11.3499-3505.2002 · Cited by 96 · see citing works
Oxidative stress response in Clostridium perfringens
Jean, D., Briolat, V., & Reysset, G. (2004) · Microbiology · doi:10.1099/mic.0.27017-0 · Cited by 78 · see citing works
Samaranayake, Y. H., Dassanayake, R. S., Jayatilake, J. A. M. S., Cheung, B., Yau, J. Y. Y., Yeung, K. W. S., & Samaranayake, L. P. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.45762-0 · Cited by 78 · see citing works
Self-citationPérez‐Torrado, R., Bruno-Bárcena, J. M., & Matallana, E. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.11.6831-6837.2005 · Cited by 71 · see citing works
Marques, M., Mojžita, D., Amorim, M. A., Almeida, T., Hohmann, S., Moradas‐Ferreira, P., & Costa, V. (2006) · Microbiology · doi:10.1099/mic.0.29040-0 · Cited by 67 · see citing works
Wang, Y., Xu, L. Y., Lam, K. S. L., Lü, G., Cooper, G. J. S., & Xu, A. (2006) · PROTEOMICS · doi:10.1002/pmic.200500840 · Cited by 53 · see citing works
Self-citationWang, Y., Lam, K. S. L., Lam, J. B. B., Lam, M. C., Leung, P. T. Y., Zhou, M., & Xu, A. (2007) · Molecular Endocrinology · doi:10.1210/me.2006-0249 · Cited by 48 · see citing works
Self-citationProteomic analysis of the pH response in the fungal pathogen Candida glabrata
Schmidt, P., Walker, J., Selway, L., Stead, D., Yin, Z., Enjalbert, B., Weig, M., & Brown, A. J. P. (2008) · PROTEOMICS · doi:10.1002/pmic.200700845 · Cited by 48 · see citing works
Safdar, A., Chaturvedi, V. P., Koll, B. S., Larone, D. H., Perlin, D. S., & Armstrong, D. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.10.3268-3272.2002 · Cited by 46 · see citing works
McMullan, R., McClurg, R. B., Xu, J., Moore, J. E., Millar, B. C., Crowe, M. J., & Hedderwick, S. A. (2002) · Journal of Infection · doi:10.1053/jinf.2002.0999 · Cited by 28 · see citing works
Uppuluri, P., Sarmah, B., & Chaffin, W. L. (2006) · Microbiology · doi:10.1099/mic.0.28745-0 · Cited by 26 · see citing works
Non-glucan Attached Proteins of Candida albicans Biofilm Formed on Various Surfaces
Vediyappan, G., & Chaffin, W. L. (2006) · Mycopathologia · doi:10.1007/s11046-005-0167-2 · Cited by 25 · see citing works
Global analysis of altered gene expression during morphogenesis of Candida albicans in vitro
Singh, V., Sinha, I., & Sadhale, P. P. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.018 · Cited by 23 · see citing works
Stead, D., Findon, H., Yin, Z., Walker, J., Selway, L., Cash, P., Dujon, B., Hennequin, C., Brown, A. J. P., & Haynes, K. (2005) · PROTEOMICS · doi:10.1002/pmic.200401064 · Cited by 22 · see citing works
Kim, H., Rakwal, R., Shibato, J., Iwahashi, H., Choi, J.-S., & Kim, D. (2006) · Water Research · doi:10.1016/j.watres.2006.02.037 · Cited by 21 · see citing works
Kim, I.-S., Yun, H.-S., & Jin, I. (2007) · PubMed · Cited by 19 · see citing works
Anil, S., Ellepola, A. N. B., & Samaranayake, L. P. (2002) · Mycopathologia · doi:10.1023/a:1014932302518 · Cited by 17 · see citing works
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Cavalheiro, M., & Teixeira, M. C. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00028 · Cited by 690 · see citing works
Ramage, G., Rajendran, R., Sherry, L., & Williams, C. (2012) · International Journal of Microbiology · doi:10.1155/2012/528521 · Cited by 583 · see citing works
Candida glabrata: A review of its features and resistance
Rodrigues, C. F., Silva, S., & Henriques, M. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-013-2009-3 · Cited by 268 · see citing works
Monteiro, D. R., Gorup, L. F., Silva, S., Negri, M., de Camargo, E. R., Oliveira, R., Barbosa, D. B., & Henriques, M. (2011) · Biofouling · doi:10.1080/08927014.2011.599101 · Cited by 205 · see citing works
Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival
Hassan, Y., Chew, S. Y., & Than, L. T. L. (2021) · Journal of Fungi · doi:10.3390/jof7080667 · Cited by 170 · see citing works
Ashraf, M. A., Ullah, S., Ahmad, I., Qureshi, A. K., Balkhair, K. S., & Rehman, M. A. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6371 · Cited by 137 · see citing works
Zhang, M., Zhang, K., Gusseme, B. D., Verstraete, W., & Field, R. (2014) · Biofouling · doi:10.1080/08927014.2013.873419 · Cited by 137 · see citing works
Candida glabrata Biofilms: How Far Have We Come?
Rodrigues, C., Rodrigues, M., Silva, S., & Henriques, M. (2017) · Journal of Fungi · doi:10.3390/jof3010011 · Cited by 129 · see citing works
Candida glabrata: A Lot More Than Meets the Eye
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Fungal Biofilms: Relevance in the Setting of Human Disease
Martinez, L. R., & Fries, B. C. (2010) · Current Fungal Infection Reports · doi:10.1007/s12281-010-0035-5 · Cited by 116 · see citing works
Timmermans, B., De Las Peñas, A., Castaño, I., & Van Dijck, P. (2018) · Journal of Fungi · doi:10.3390/jof4020060 · Cited by 109 · see citing works
Monteiro, D. R., Silva, S. M., Negri, M., Gorup, L. F., Camargo, E. R., Oliveira, R., Barbosa, D. B., & Henriques, M. (2013) · Mycoses · doi:10.1111/myc.12093 · Cited by 94 · see citing works
CandidaBiofilms and the Host: Models and New Concepts for Eradication
Tournu, H., & Dijck, P. V. (2011) · International Journal of Microbiology · doi:10.1155/2012/845352 · Cited by 91 · see citing works
Multi-omics tools for studying microbial biofilms: current perspectives and future directions
Seneviratne, C. J., Suriyanarayanan, T., Widyarman, A. S., Lee, L. S., Lau, M., Ching, J., Delaney, C., & Ramage, G. (2020) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2020.1828817 · Cited by 89 · see citing works
Self-citationBacterial identification: from the agar plate to the mass spectrometer
Braga, P. A. D. C., Tata, A., Santos, V. G., Barreiro, J. R., Schwab, N. V., dos Santos, M. V., Eberlin, M. N., & Ferreira, C. R. (2012) · RSC Advances · doi:10.1039/c2ra22063f · Cited by 81 · see citing works
Proteomic Profile of Cryptococcus neoformans Biofilm Reveals Changes in Metabolic Processes
Santi, L., Beys‐da‐Silva, W. O., Berger, M., Calzolari, D., Guimarães, J. A., Moresco, J. J., & Yates, J. R. (2014) · Journal of Proteome Research · doi:10.1021/pr401075f · Cited by 78 · see citing works
Tiwari, V., Vashistt, J., Kapil, A., & Moganty, R. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039451 · Cited by 76 · see citing works
Medically Important Fungi Respond to Azole Drugs: An Update
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Unraveling the resistance of microbial biofilms: Has proteomics been helpful?
Seneviratne, C. J., Wang, Y., Jin, L., Wong, S. S. W., Herath, T. D. K., & Samaranayake, L. P. (2012) · PROTEOMICS · doi:10.1002/pmic.201100356 · Cited by 56 · see citing works
Self-citationGenome structure and dynamics of the yeast pathogen Candida glabrata
Ahmad, K. M., Kokošar, J., Guo, X., Gu, Z., Ishchuk, O. P., & Piškur, J. (2014) · FEMS Yeast Research · doi:10.1111/1567-1364.12145 · Cited by 57 · see citing works
The Clinical Importance of Fungal Biofilms
Ramage, G., & Williams, C. (2013) · Advances in applied microbiology · doi:10.1016/b978-0-12-407673-0.00002-3 · Cited by 54 · see citing works
Biofilm formation inCandida glabrata: What have we learnt from functional genomics approaches?
d’Enfert, C., & Janbon, G. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov111 · Cited by 54 · see citing works
Metaproteome and metabolome of oral microbial communities
Bostancı, N., Grant, M. M., Bao, K., Silbereisen, A., Hetrodt, F., Manoil, D., & Belibasakis, G. N. (2020) · Periodontology 2000 · doi:10.1111/prd.12351 · Cited by 50 · see citing works
Leung, C., Chan, Y. C., Samaranayake, L. P., & Seneviratne, C. J. (2012) · Journal of Hospital Infection · doi:10.1016/j.jhin.2011.09.014 · Cited by 47 · see citing works
Self-citationCandida biofilms associated with CVC and medical devices
Chandra, J., Mukherjee, P. K., & Ghannoum, M. A. (2012) · Mycoses · doi:10.1111/j.1439-0507.2011.02149.x · Cited by 47 · see citing works
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Prasad, T. S. K., Gowda, H., Keerthikumar, S., Sekhar, N. R., Selvan, L. D. N., Kumar, P., Pinto, S. M., Muthusamy, B., Subbannayya, Y., Renuse, S., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr200827k · Cited by 46 · see citing works
Rodrigues, C. F., & Henriques, M. (2017) · Pathogens · doi:10.3390/pathogens6040062 · Cited by 47 · see citing works
New regulators of biofilm development in Candida glabrata
Riera, M., Mogensen, E., d’Enfert, C., & Janbon, G. (2012) · Research in Microbiology · doi:10.1016/j.resmic.2012.02.005 · Cited by 43 · see citing works
Candida/Candida biofilms. First description of dual-species Candida albicans/C. rugosa biofilm
Martins, C. H. G., Pires, R. H., Cunha, A. O., Pereira, C. A., Singulani, J. D. L., Abrão, F., de Moraes, T., & Mendes‐Giannini, M. J. S. (2016) · Fungal Biology · doi:10.1016/j.funbio.2016.01.013 · Cited by 41 · see citing works
Barber, A. E., Weber, M., Kaerger, K., Linde, J., Gölz, H., Duerschmied, D., Markert, A., Guthke, R., Walther, G., & Kurzai, O. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01628-18 · Cited by 32 · see citing works
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Rasheed, M., Battu, A., & Kaur, R. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2020.1792773 · Cited by 30 · see citing works
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Proteomics dedicated to biofilmology: What have we learned from a decade of research?
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Zampieri, D., Santos, V. G., Braga, P. A. D. C., Ferreira, C. R., Ballottin, D., Tasić, L., Basso, A. C., Sanches, B. V., Pontes, J. H. F., da Silva, B. P., et al. (2013) · Theriogenology · doi:10.1016/j.theriogenology.2013.04.020 · Cited by 26 · see citing works
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Tati, S., Jang, W. S., Li, R. Q., Kumar, R., Puri, S., & Edgerton, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061480 · Cited by 25 · see citing works
Enterococcus faecalis promotes osteoclastogenesis and semaphorin 4D expression
Wang, S., Deng, Z.-H., Seneviratne, C., Cheung, G., Jin, L., Zhao, B.-H., & Zhang, C.-F. (2015) · Innate Immunity · doi:10.1177/1753425915593162 · Cited by 24 · see citing works
Self-citationCavalheiro, M., Pereira, D., Formosa‐Dague, C., Leitão, C., Pais, P., Ndlovu, E., Viana, R., Pimenta, A. I., Santos, R., Takahashi‐Nakaguchi, A., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02412-7 · Cited by 19 · see citing works
The Ins and Outs of Azole Antifungal Drug Resistance: Molecular Mechanisms of Transport
Zavřel, M., Esquivel, B. D., & White, T. C. (2017) · Springer eBooks · doi:10.1007/978-1-4939-0694-9_29 · Cited by 20 · see citing works
Madhavan, P., Jamal, F., Chong, P. P., Othman, F., Karunanidhi, A., & Ng, K. P. (2018) · Mycopathologia · doi:10.1007/s11046-018-0243-z · Cited by 19 · see citing works
Ceballos-Garzon, A., Monteoliva, L., Gil, C., Alvarez-Moreno, C., Vega-Vela, N. E., Engelthaler, D. M., Bowers, J., Le Pape, P., & Parra-Giraldo, C. M. (2022) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkab454 · Cited by 18 · see citing works
Song, J. F., Zhang, S., Xing, J., Zhang, L., Wang, J., & Shan, A. S. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.09.017 · Cited by 18 · see citing works
Samaranayake, Y. H., Cheung, B. P. K., Wang, Y., Yau, J. Y. Y., Yeung, K. W. S., & Samaranayake, L. P. (2012) · Journal of Medical Microbiology · doi:10.1099/jmm.0.044123-0 · Cited by 18 · see citing works
Self-citationYang, J., Ma, Y., Zhang, P., Chen, H., Liu, Z., & Qin, H. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00107 · Cited by 17 · see citing works
Lotfali, E., Fattahi, A., Sayyahfar, S., Ghasemi, R., Rabiei, M. M., Fathi, M., Vakili, K. G., Deravi, N., Soheili, A., Toreyhi, H., et al. (2021) · Microbial Drug Resistance · doi:10.1089/mdr.2020.0235 · Cited by 17 · see citing works
Raj, V., Raorane, C. J., Shastri, D., Kim, S., & Lee, S.-K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129774 · Cited by 16 · see citing works
Characterization of thiamine uptake and utilization in Candida spp. subjected to oxidative stress
Wolak, N., Tomasi, M., Kozik, A., & Rąpała‐Kozik, M. (2015) · Acta Biochimica Polonica · doi:10.18388/abp.2015_1044 · Cited by 14 · see citing works
Santi, L., Oliveira, M. B., Guimarães, J. A., Calegari-Alves, Y. P., Vainstein, M. H., Yates, J. R., & Beys‐da‐Silva, W. O. (2023) · Journal of Proteomics · doi:10.1016/j.jprot.2023.105022 · Cited by 12 · see citing works
Cell Surface Expression of Nrg1 Protein in Candida auris
Paudyal, A., & Vediyappan, G. (2021) · Journal of Fungi · doi:10.3390/jof7040262 · Cited by 12 · see citing works
Jha, A., & Kumar, A. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0479 · Cited by 12 · see citing works
Wei, T., Zheng, N., Zheng, H., Chen, Y., Hong, P., Liu, W., & Liu, M. (2022) · Medical Mycology · doi:10.1093/mmy/myac084 · Cited by 10 · see citing works
Molecular investigations on Candida glabrata clinical isolates for pharmacological targeting
Gupta, H., Gupta, P., Kairamkonda, M., & Poluri, K. M. (2022) · RSC Advances · doi:10.1039/d2ra02092k · Cited by 9 · see citing works
Owens, R. A., & Doyle, S. (2021) · Expert Review of Proteomics · doi:10.1080/14789450.2021.1912601 · Cited by 8 · see citing works
The Effect of Fermented Lingonberry Juice onCandida glabrataIntracellular Protein Expression
Pärnänen, P., Nawaz, A., Sorsa, T. A., Meurman, J. H., & Nikula-Ijäs, P. (2017) · International Journal of Dentistry · doi:10.1155/2017/6185395 · Cited by 7 · see citing works
Ishchuk, O. P., Sterner, O., Ellervik, U., & Manner, S. (2019) · Antibiotics · doi:10.3390/antibiotics9010010 · Cited by 7 · see citing works
Evolution of regulatory networks inCandida glabrata: learning to live with the human host
Roy, S., & Thompson, D. A. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov087 · Cited by 7 · see citing works
Impact of infectious Candida albicans biofilm on biomaterials
Singh, N., Agrawal, V. P., Pemmaraju, S. C., Panwar, R., & Pruthi, V. (2011) · Cited by 5 · see citing works
The Ins and Outs of Azole Antifungal Drug Resistance: Molecular Mechanisms of Transport
Zavřel, M., Esquivel, B. D., & White, T. C. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0667-3_29-1 · Cited by 5 · see citing works
Host-Fungal Interactions: Pathogenicity versus Immunity
Tavanti, A., Naglik, J. R., & Osherov, N. (2012) · International Journal of Microbiology · doi:10.1155/2012/562480 · Cited by 3 · see citing works
Biofilm Formation in Candida Species
Elibe, M. I., & Innocent, N. E. (2024) · Springer eBooks · doi:10.1007/978-981-97-4909-6_9 · Cited by 2 · see citing works
Radchenkova, N., Stefanova, P. P., & Gouliamova, D. E. (2025) · Life · doi:10.3390/life15060889 · Cited by 3 · see citing works
Silver Nanoparticles to Fight Candida Coinfection in the Oral Cavity
Monteiro, D. R., Silva, S. M., Negri, M., Gorup, L. F., Camargo, E. R., Barbosa, D. B., & Henriques, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801317-5.00017-7 · Cited by 2 · see citing works
Proteomics in Drug Discovery and Development
Wang, M., & Witzmann, F. A. (2012) · Encyclopedia of Drug Metabolism and Interactions · doi:10.1002/9780470921920.edm080 · Cited by 2 · see citing works
Ateş, G. Ö., & Otkun, M. T. (2023) · Sinop Üniversitesi Fen Bilimleri Dergisi · doi:10.33484/sinopfbd.1310745 · Cited by 1 · see citing works
Andreu, C., & del Olmo, M. (2024) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2024.100242 · Cited by 1 · see citing works
Omics-Based Therapeutics Against Biofilm Mechanics
Nagarajan, H., Ranganathan, S., Chitipothu, S., Sangavi, P., & Mariasoosai, R. C. C. (2025) · Springer eBooks · doi:10.1007/978-3-031-91863-6_18 · Cited by 1 · see citing works
Candidemia por Candida glabrata en paciente joven sin enfermedad previa
González, I. M., Salanova, F. L., Orellana, J. L. B., Lozano-Espinosa, M., & Hernández, M. L. (2013) · Medicina de Familia SEMERGEN · doi:10.1016/j.semerg.2012.11.006
Stress response and drug resistance of Candida albicans
Huang, H., Wang, Y., Li, Y., Xu, Y., & Jiang, Y. (2010) · Academic Journal of Second Military Medical University · doi:10.3724/sp.j.1008.2010.01239
Self-citationProteomics Approaches to Uncover the Drug Resistance Mechanisms of Microbial Biofilms
Seneviratne, C. J., Suriyanarayanan, T., Lin, Q., & Vizcaíno, J. A. (2017) · Routledge eBooks · doi:10.4324/9781315120119-6
Self-citation(2010) · Yeast · doi:10.1002/yea.1722
Trentin, G. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2022.tde-20062022-161952
- Authors
- Seneviratne, C. J., Wang, Y., Jin, L., Abiko, Y., & Samaranayake, L. P.
- Affiliations
- University of Hong Kong (HK)
- Nihon University (JP)
- Corresponding author
- Samaranayake, Lakshman P.
- Venue
- PROTEOMICS
- Publisher
- Wiley
- Published
- 2010-04
- Volume
- 10
- Issue
- 7
- Pages
- 1444-1454
- ISSN
- 1615-9853 (ISSN-L)
- 1615-9861
- OpenAlex
- W2038113654
- Cited by
- 74
- References
- 51
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 2 · 2015: 7 · 2014: 4 · 2013: 7 · 2012: 10
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PROTEOMICS (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- Hong Kong Research Grants Council (HKU 7624/06M)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Candida glabrata, biofilm, antifungal resistance, planktonic versus biofilm growth, proteomic profiling, stress proteins, biocide resistance, fungal virulence factors, differentially expressed proteins
- MeSH terms
- Stress, Physiological, Electrophoresis, Gel, Two-Dimensional, Polymerase Chain Reaction, Biofilms, Gene Expression Profiling, Drug Resistance, Fungal, Proteomics, Candida glabrata
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