Cited by 1,256Oral microbiology and periodontitis researchBacterial biofilms and quorum sensingDental Health and Care Utilization

The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.

Are dental diseases examples of ecological catastrophes?

Marsh, P. D.·2003·Microbiology

DOI 10.1099/mic.0.26082-0

Open this paper in CoChat — free account

Abstract

Dental diseases are among the most prevalent and costly diseases affecting industrialized societies, and yet are highly preventable. The microflora of dental plaque biofilms from diseased sites is distinct from that found in health, although the putative pathogens can often be detected in low numbers at normal sites. In dental caries, there is a shift towards community dominance by acidogenic and acid-tolerant Gram-positive bacteria (e.g. mutans streptococci and lactobacilli) at the expense of the acid-sensitive species associated with sound enamel. In contrast, the numbers and proportions of obligately anaerobic bacteria, including Gram-negative proteolytic species, increase in periodontal diseases. Modelling studies using defined consortia of oral bacteria grown in planktonic and biofilm systems have been undertaken to identify environmental factors responsible for driving these deleterious shifts in the plaque microflora. Repeated conditions of low pH (rather than sugar availability per se) selected for mutans streptococci and lactobacilli, while the introduction of novel host proteins and glycoproteins (as occurs during the inflammatory response to plaque), and the concomitant rise in local pH, enriched for Gram-negative anaerobic and asaccharolytic species. These studies emphasized (a). significant properties of dental plaque as both a biofilm and a microbial community, and (b). the dynamic relationship existing between the environment and the composition of the oral microflora. This research resulted in a novel hypothesis (the 'ecological plaque hypothesis') to better describe the relationship between plaque bacteria and the host in health and disease. Implicit in this hypothesis is the concept that disease can be prevented not only by directly inhibiting the putative pathogens, but also by interfering with the environmental factors driving the selection and enrichment of these bacteria. Thus, a more holistic approach can be taken in disease control and management strategies.

Integrity signals

Registry

Crossref · 10.1099/mic.0.26082-0

Cites

105 of 105 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Microbial complexes in subgingival plaque
Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02419.x · Cited by 5,050
MICROBIAL BIOFILMS
Costerton, J. W., Lewandowski, Z., Caldwell, D. E., Korber, D. R., & Lappin-Scott, H. M. (1995) · Annual Review of Microbiology · doi:10.1146/annurev.mi.49.100195.003431 · Cited by 4,921
Role of Streptococcus mutans in human dental decay
Loesche, W. J. (1986) · Microbiological Reviews · doi:10.1128/mr.50.4.353-380.1986 · Cited by 3,360
Bacterial Biofilms in Nature and Disease
Costerton, J. W., Cheng, K. J., Geesey, G. G., Ladd, T. I., Nickel, J. C., Dasgupta, M., & Marrie, T. J. (1987) · Annual Review of Microbiology · doi:10.1146/annurev.mi.41.100187.002251 · Cited by 3,145
Bacterial Diversity in Human Subgingival Plaque
Paster, B. J., Boches, S. K., Galvin, J. L., Ericson, R. E., Lau, C. N., Levanos, V. A., Sahasrabudhe, A., & Dewhirst, F. E. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.12.3770-3783.2001 · Cited by 2,008
Role of Streptococcus mutans in human dental decay.
Loeshe, W. J. (1986) · Medical Entomology and Zoology · Cited by 1,346
Microbial ecology of dental plaque and its significance in health and disease
Marsh, P. D. (1994) · Advances in Dental Research · doi:10.1177/08959374940080022001 · Cited by 1,278
Self-citation
The bacteria of periodontal diseases
Moore, W. E., & Moore, L. V. H. (1994) · Periodontology 2000 · doi:10.1111/j.1600-0757.1994.tb00019.x · Cited by 1,077
Biofilms, the customized microniche
Costerton, J. W., Lewandowski, Z., de Beer, D., Caldwell, D. E., Korber, D. R., & James, G. A. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.8.2137-2142.1994 · Cited by 999
Adhere today, here tomorrow: oral bacterial adherence
Kolenbrander, P. E., & London, J. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.11.3247-3252.1993 · Cited by 717

Flagged first, then by citations

Show all 105 references

Research works printed but not linked: 15

Alexander, 1971, Microbial Ecology
Birkedal-Hansen, 1998, Links between microbial colonization, inflammatory response and tissue destruction, 170
Bowden, 1976, The microflora associated with developing carious lesions of the distal surfaces of the upper first premolars in 13–14 year old children, 233
Ellwood, 1976, The mouth as a chemostat, 270
Hamilton, 1987, Effects of changing environment on sugar transport and metabolism by oral bacteria, 94
Lamont, 2000, Adhesion as an ecological determinant in the oral cavity, 131
Marsh, 1989, Host defenses and microbial homeostasis: role of microbial interactions, J Dent Res, 68, 1567
Marsh, 2000b, Oral ecology and its impact on oral microbial diversity, 11
Marsh, 1998, Dental plaque: community spirit in action, 41
Marsh, 1999, Microbial community aspects of dental plaque, 237
Marsh, 1999, Oral Microbiology
Marsh, 1993, Continuous culture studies, 105
Marsh, 2002, Effect of a redox agent on obligate anaerobes in oral microbial communities, J Dent Res, 81, A
Rosebury, 1962, Micro-organisms Indigenous to Man
Sanders, 1984, Modification of normal flora by antibiotics: effects on individuals and the environment, 217

Sorted by citations

Items 301–400 of 1,000

On putative periodontal pathogens: an epidemiological perspective
López, R., Hujoel, P. P., & Belibasakis, G. N. (2015) · Virulence · doi:10.1080/21505594.2015.1014266 · Cited by 60
Molecular approaches for viable bacterial population and transcriptional analyses in a rodent model of dental caries
Klein, M. I., Scott‐Anne, K., Gregoire, S., Rosalen, P. L., & Koo, H. (2012) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2012.00647.x · Cited by 60
The Oral–Gut Microbiome–Brain Axis in Cognition
Adil, N. A., Omo-erigbe, C., Yadav, H., & Jain, S. (2025) · Microorganisms · doi:10.3390/microorganisms13040814 · Cited by 65
Candida albicansin oral biofilms could prevent caries
Willems, H. M. E., Kos, K., Jabra‐Rizk, M. A., & Krom, B. P. (2016) · Pathogens and Disease · doi:10.1093/femspd/ftw039 · Cited by 60
Dental diseases – are these examples of ecological catastrophes?
Marsh, P. D. (2006) · International Journal of Dental Hygiene · doi:10.1111/j.1601-5037.2006.00195.x · Cited by 58
Self-citation
Effect of nicotine on dual-species biofilms of Streptococcus mutans and Streptococcus sanguinis
Li, M., Huang, R., Zhou, X., Zhang, K., Zheng, X. M., & Gregory, R. L. (2013) · FEMS Microbiology Letters · doi:10.1111/1574-6968.12317 · Cited by 58
Characterization of antibiotic resistance determinants in oral biofilms
Kim, S.-M., Kim, H. C., & Lee, S.-W. S. (2011) · The Journal of Microbiology · doi:10.1007/s12275-011-0519-1 · Cited by 57
Role of Urease Enzymes in Stability of a 10-Species Oral Biofilm Consortium Cultivated in a Constant-Depth Film Fermenter
Shu, M., Browngardt, C. M., Chen, Y. M., & Burne, R. A. (2003) · Infection and Immunity · doi:10.1128/iai.71.12.7188-7192.2003 · Cited by 57
Advances in mathematical modeling of biofilm structure
Picioreanu, C., Xavier, J. B., & van Loosdrecht, M. C. M. (2004) · Biofilms · doi:10.1017/s1479050505001572 · Cited by 57
Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application
Hajishengallis, G., Hajishengallis, E., Kajikawa, T., Wang, B., Yancopoulou, D., Ricklin, D., & Lambris, J. D. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.03.006 · Cited by 57
Microcosm Biofilms Originating from Children with Different Caries Experience Have Similar Cariogenicity under Successive Sucrose Challenges
Azevedo, M. S., van de Sande, F. H., Romano, A. R., & Cenci, M. S. (2011) · Caries Research · doi:10.1159/000331210 · Cited by 56
Functional Relationship between Sucrose and a Cariogenic Biofilm Formation
Cai, J.-N., Jung, J., Dang, M.-H., Kim, M., Yi, H., & Jeon, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157184 · Cited by 56
Anti-Caries Effects of Dental Adhesives Containing Quaternary Ammonium Methacrylates with Different Chain Lengths
Han, Q., Li, B., Zhou, X., Yang, G., Wang, S., Li, M., Ren, B., Wang, H., Zhang, K., Xu, H. H. K., et al. (2017) · Materials · doi:10.3390/ma10060643 · Cited by 56
Acid tolerance properties of dental biofilms in vivo
Senneby, A., Davies, Jr., Svensäter, G., & Neilands, J. (2017) · BMC Microbiology · doi:10.1186/s12866-017-1074-7 · Cited by 54
Determination of the In Vitro and In Vivo Antimicrobial Activity on Salivary Streptococci and Lactobacilli and Chemical Characterisation of the Phenolic Content of a Plantago lanceolata Infusion
Ferrazzano, G. F., Cantile, T., Roberto, L., Ingenito, A., Catania, M. R., Roscetto, E., Palumbo, G. A., Zarrelli, A., & Pollio, A. (2015) · BioMed Research International · doi:10.1155/2015/286817 · Cited by 55
Oral microbial biofilm models and their application to the testing of anticariogenic agents
Sim, C. P. C., Dashper, S. G., & Reynolds, E. C. (2016) · Journal of Dentistry · doi:10.1016/j.jdent.2016.04.010 · Cited by 55
Development of a novel multi‐triplex qPCR method for the assessment of bacterial community structure in oral populations
Ciric, L., Pratten, J. R., Wilson, M., & Spratt, D. A. (2010) · Environmental Microbiology Reports · doi:10.1111/j.1758-2229.2010.00183.x · Cited by 54
Effect of khat chewing on periodontal pathogens in subgingival biofilm from chronic periodontitis patients
Al-Hebshi, N. N., Al-Sharabi, A. K., Shuga-Aldin, H. M., Al‐Haroni, M., & Ghandour, I. A. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.08.051 · Cited by 54
Recovery of Acid Production in Streptococcus mutans Biofilms after Short-Term Fluoride Treatment
Dang, M.-H., Jung, J., Lee, D., Song, K., & Jeon, J. (2016) · Caries Research · doi:10.1159/000446408 · Cited by 54
Acid tolerance in early colonizers of oral biofilms
Boisen, G., Davies, J. R., & Neilands, J. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02089-2 · Cited by 54
Antimicrobial and antibiofilm activities of Casearia sylvestris extracts from distinct Brazilian biomes against Streptococcus mutans and Candida albicans
Ribeiro, S. M., Fratucelli, É. D. O., Bueno, P. C. P., de Castro, M. K. V., Francisco, A. A., Cavalheiro, A. J., & Klein, M. I. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2717-z · Cited by 57
The specific degree-of-polymerization of A-type proanthocyanidin oligomers impactsStreptococcus mutansglucan-mediated adhesion and transcriptome responses within biofilms
Feng, G., Klein, M. I., Gregoire, S., Singh, A. P., Vorsa, N., & Koo, H. (2013) · Biofouling · doi:10.1080/08927014.2013.794456 · Cited by 52
Microbiology and Treatment of Endodontic Infections
Siqueira, J. F., Jr., & Rôças, I. N. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-06489-7.00015-1 · Cited by 58
Preliminary study of the oral mycobiome of children with and without dental caries
Fechney, J. M., Browne, G. V., Prabhu, N. T., Irinyi, L., Meyer, W., Hughes, T. E., Bockmann, M. R., Townsend, G. C., Salehi, H., & Adler, C. J. (2018) · Journal of Oral Microbiology · doi:10.1080/20002297.2018.1536182 · Cited by 56
Antibacterial Peptides: Opportunities for the Prevention and Treatment of Dental Caries
Pepperney, A., & Chikindas, M. L. (2011) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-011-9076-5 · Cited by 54
Bifidobacteria inhibit the growth of Porphyromonas gingivalis but not of Streptococcus mutans in an in vitro biofilm model
Jäsberg, H., Söderling, E. M., Endo, A., Beighton, D., & Haukioja, A. L. (2016) · European Journal Of Oral Sciences · doi:10.1111/eos.12266 · Cited by 52
Smoking, pregnancy and the subgingival microbiome
Paropkari, A. D., Leblebicioğlu, B., Christian, L. M., & Kumar, P. (2016) · Scientific Reports · doi:10.1038/srep30388 · Cited by 53
Genomic and phenotypic diversity of Streptococcus mutans
Bedoya‐Correa, C. M., Rincón‐Rodríguez, R. J., & Parada-Sánchez, M. T. (2018) · Journal of Oral Biosciences · doi:10.1016/j.job.2018.11.001 · Cited by 55
Klebsiella and Providencia emerge as lone survivors following long-term starvation of oral microbiota
Baker, J. L., Hendrickson, E. L., Tang, X., Lux, R., He, X., Edlund, A., McLean, J. S., & Shi, W. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820594116 · Cited by 52
Acidic Proline-rich Protein Db and Caries in Young Children
Zakhary, G., Clark, R. M., Bidichandani, S. I., Owen, W. L., Slayton, R. L., & Levine, M. (2007) · Journal of Dental Research · doi:10.1177/154405910708601207 · Cited by 51
A Defined-Multispecies Microbial Model for Studying Enamel Caries Development
Arthur, R., Waeiss, R. A., Hara, A., Lippert, F., Eckert, G., & Zero, D. (2013) · Caries Research · doi:10.1159/000347050 · Cited by 46
Caries Experience and Quantification of Streptococcus mutans and Streptococcus sobrinus in Saliva of Sudanese Schoolchildren
Nurelhuda, N. M., Al‐Haroni, M., Trovik, T. A., & Bakken, V. (2010) · Caries Research · doi:10.1159/000316664 · Cited by 51
Streptococcus mutans, Streptococcus sobrinus and Candida albicans in oral samples from caries-free and caries-active children
Fragkou, S., Balasouli, C., Tsuzukibashi, O., Argyro, A., Menexes, G. C., Kotsanos, N., & Kalfas, S. (2016) · European Archives of Paediatric Dentistry · doi:10.1007/s40368-016-0239-7 · Cited by 51
Added Sugar Consumption and Chronic Oral Disease Burden among Adolescents in Brazil
do Carmo, C. D. S., Ribeiro, M. R. C., Teixeira, J. X. P., Alves, C. M. C., Franco, M. M., França, A. K. T. D. C., Benatti, B. B., Cunha‐Cruz, J., & Ribeiro, C. C. C. (2018) · Journal of Dental Research · doi:10.1177/0022034517745326 · Cited by 50
Inhibition ofStreptococcus mutansbiofilm accumulation and development of dental cariesin vivoby 7-epiclusianone and fluoride
Murata, R. M., Branco‐de‐Almeida, L. S., Franco, E. M., Yatsuda, R., dos Santos, M. H., de Alencar, S. M., Koo, H., & Rosalen, P. L. (2010) · Biofouling · doi:10.1080/08927014.2010.527435 · Cited by 51
Host‐microbe interactions: Profiles in the transcriptome, the proteome, and the metabolome
Nguyen, T., Sedghi, L., Ganther, S., Malone, E., Kamarajan, P., & Kapila, Y. L. (2020) · Periodontology 2000 · doi:10.1111/prd.12316 · Cited by 51
Multifactorial Contributors to the Longevity of Dental Restorations: An Integrated Review of Related Factors
Santos, M. J. M. C., Zare, E., McDermott, P., & Santos, G. C. (2024) · Dentistry Journal · doi:10.3390/dj12090291 · Cited by 58
Socioeconomic and Sociodemographic Variables Associated With Oral Hygiene Status in Mexican Schoolchildren Aged 6 to 12 Years
Villalobos-Rodelo, J. J., Medina‐Solís, C. E., Maupomé, G., Vallejos-Sánchez, A. A., Lau‐Rojo, L., & de León-Viedas, M. V. P. (2007) · Journal of Periodontology · doi:10.1902/jop.2007.060324 · Cited by 50
Microbial profiling of dental plaque from mechanically ventilated patients
Sands, K. M., Twigg, J. A., Lewis, M. A. O., Wise, M. P., Marchesi, J. R., Smith, A., Wilson, M. J., & Williams, D. W. (2015) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000212 · Cited by 51
The copYAZ Operon Functions in Copper Efflux, Biofilm Formation, Genetic Transformation, and Stress Tolerance in Streptococcus mutans
Singh, K., Senadheera, D. B., Levesque, C. M., & Cvitkovitch, D. G. (2015) · Journal of Bacteriology · doi:10.1128/jb.02433-14 · Cited by 50
Periapical fluid RANKL and IL-8 are differentially regulated in pulpitis and apical periodontitis
Rechenberg, D., Bostancı, N., Zehnder, M., & Belibasakis, G. N. (2014) · Cytokine · doi:10.1016/j.cyto.2014.05.014 · Cited by 49
A role for the DtxR family of metalloregulators in gram-positive pathogenesis
Merchant, A. T., & Spatafora, G. A. (2013) · Molecular Oral Microbiology · doi:10.1111/omi.12039 · Cited by 51
Microbiological diagnostics in oral diseases
Dahlén, G. (2006) · Acta Odontologica Scandinavica · doi:10.1080/00016350500520318 · Cited by 49
Biofilm extracellular polysaccharides degradation during starvation and enamel demineralization
Costa Oliveira, B. E., Cury, J. A., & Ricomini Filho, A. P. (2017) · PLOS ONE · doi:10.1371/journal.pone.0181168 · Cited by 40
Tea polyphenols: application in the control of oral microorganism infectious diseases
Li, Y., Jiang, X., Hao, J., Zhang, Y., & Huang, R. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.03.027 · Cited by 49
Microbial diagnostics in periodontal diseases
Manoil, D., Parga, A., Bostancı, N., & Belibasakis, G. N. (2024) · Periodontology 2000 · doi:10.1111/prd.12571 · Cited by 51
Quorum sensing regulation of biofilm growth and gene expression by oral bacteria and periodontal pathogens
Shao, H., & Demuth, D. R. (2009) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00318.x · Cited by 48
Arginine promotes fluoride uptake into artificial carious lesionsin vitro
Cheng, X., Xu, P., Zhou, X., Deng, M., Cheng, L., Li, M., Li, Y., & Xu, X. (2015) · Australian Dental Journal · doi:10.1111/adj.12278 · Cited by 48
Growth Phase and pH Influence Peptide Signaling for Competence Development in Streptococcus mutans
Guo, Q., Ahn, S., Kaspar, J. R., Zhou, X., & Burne, R. A. (2013) · Journal of Bacteriology · doi:10.1128/jb.00995-13 · Cited by 48
Polyamine biomarkers as indicators of human disease
Amin, M., Tang, S., Shalamanova, L., Taylor, R. L., Wylie, S. R., Abdullah, B. M., & Whitehead, K. A. (2021) · Biomarkers · doi:10.1080/1354750x.2021.1875506 · Cited by 51
Quorum sensing systems as a new target to prevent biofilm‐related oral diseases
Muras, A., Mallo, N., Otero‐Casal, P., Pose-Rodríguez, J. M., & Otero, A. (2020) · Oral Diseases · doi:10.1111/odi.13689 · Cited by 47
Proteomic profiling of host-biofilm interactions in an oral infection model resembling the periodontal pocket
Bao, K., Belibasakis, G. N., Selevsek, N., Grossmann, J., & Bostancı, N. (2015) · Scientific Reports · doi:10.1038/srep15999 · Cited by 47
In vitrophenotypic differentiation towards commensal and pathogenic oral biofilms
Janus, M. M., Keijser, B. J. F., Bikker, F. J., Exterkate, R. A. M., Crielaard, W., & Krom, B. P. (2015) · Biofouling · doi:10.1080/08927014.2015.1067887 · Cited by 49
Repurposing Toremifene for Treatment of Oral Bacterial Infections
Gerits, E., Defraine, V., Vandamme, K., Cremer, K. D., Brucker, K. D., Thevissen, K., Cammue, B. P. A., Beullens, S., Fauvart, M., Verstraeten, N., et al. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01846-16 · Cited by 47
Sucrose challenges to Streptococcus mutans biofilms and the curve fitting for the biofilm changes
Cai, J.-N., Jung, J., Lee, M., Choi, H.-M., & Jeon, J. (2018) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiy091 · Cited by 47
A Single Dose of Nitrate Increases Resilience Against Acidification Derived From Sugar Fermentation by the Oral Microbiome
Rosier, B. T., Carlos, P., García‐Esteban, S., Artacho, A., Galiana, A., & Mira, Á. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.692883 · Cited by 47
The Use of Probiotics as Adjuvant Therapy of Periodontal Treatment: A Systematic Review and Meta-Analysis of Clinical Trials
Hardan, L., Bourgi, R., Cuevas‐Suárez, C. E., Flores-Rodríguez, M., Omaña-Covarrubias, A., Nicastro, M., Lăzărescu, F., Żarow, M., Monteiro, P., Jakubowicz, N., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051017 · Cited by 50
Effects of Lactobacillus reuteri-derived biosurfactant on the gene expression profile of essential adhesion genes (gtfB, gtfC and ftf) of Streptococcus mutans
Salehi, R., Savabi, O., Kazemi, M., Kamali, S., Salehi, A., Eslami, G., & Tahmourespour, A. (2014) · Advanced Biomedical Research · doi:10.4103/2277-9175.139134 · Cited by 46
Comparative effect of a stannous fluoride toothpaste and a sodium fluoride toothpaste on a multispecies biofilm
Cheng, X., Liu, J., Li, J., Zhou, X., Wang, L., Liu, J., & Xu, X. (2016) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2016.10.030 · Cited by 46
The potential ecological effects of casein phosphopeptide‐amorphous calcium phosphate in dental caries prevention
Philip, N. I., & Walsh, L. J. (2018) · Australian Dental Journal · doi:10.1111/adj.12661 · Cited by 46
Inhibitory activity of Dodonaea viscosa var. angustifolia extract against Streptococcus mutans and its biofilm
Naidoo, R., Patel, M., Gulube, Z., & Fenyvesi, I. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.08.045 · Cited by 46
Salivary nitrate--an ecological factor in reducing oral acidity
Li, H., Thompson, I., Carter, P., Whiteley, A., Bailey, M., Leifert, C., & Killham, K. (2007) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2007.00313.x · Cited by 45
Illuminating the oral microbiome and its host interactions: animal models of disease
Hajishengallis, G. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad018 · Cited by 49
Casein Phosphopeptide-Amorphous Calcium Phosphate Reduces Streptococcus mutans Biofilm Development on Glass Ionomer Cement and Disrupts Established Biofilms
Dashper, S. G., Catmull, D. V., Liu, S.-W., Myroforidis, H., Zalizniak, I., Palamara, J. E. A., Huq, N. L., & Reynolds, E. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162322 · Cited by 45
Threats to adhesive/dentin interfacial integrity and next generation bio‐enabled multifunctional adhesives
Spencer, P., Ye, Q., Song, L., Parthasarathy, R., Boone, K., Misra, A. K., & Tamerler, C. (2019) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34358 · Cited by 45
pH-Responsive Biomaterials for the Treatment of Dental Caries—A Focussed and Critical Review
He, Y., Vasilev, K. A., & Zilm, P. S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071837 · Cited by 50
Acidogenicity and acidurance of dental plaque and saliva sediment from adults in relation to caries activity and chlorhexidine exposure
Andreadis, G., Topitsoglou, V., & Kalfas, S. (2015) · Journal of Oral Microbiology · doi:10.3402/jom.v7.26197 · Cited by 44
Elevated Incidence of Dental Caries in a Mouse Model of Cystic Fibrosis
Catalán, M. A., Scott-Anne, K., Klein, M. I., Koo, H., Bowen, W. H., & Melvin, J. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016549 · Cited by 44
In vitro interaction of chronic wound bacteria in biofilms
Malic, S., Hill, K. E., Playle, R., Thomas, D. W., & Williams, D. W. (2011) · Journal of Wound Care · doi:10.12968/jowc.2011.20.12.569 · Cited by 45
The caries preventive effect of 1-year use of low-dose xylitol chewing gum. A randomized placebo-controlled clinical trial in high-caries-risk adults
Cocco, F., Carta, G., Cagetti, M. G., Strohmenger, L., Lingström, P., & Campus, G. (2017) · Clinical Oral Investigations · doi:10.1007/s00784-017-2075-5 · Cited by 44
Bacterial biofilm formation, pathogenicity, diagnostics and control: An overview
Sawhney, R., & Berry, V. (2009) · Indian Journal of Medical Sciences · doi:10.4103/0019-5359.55113 · Cited by 44
Simultaneous Photodynamic Eradication of Tooth Biofilm and Tooth Whitening with an Aggregation‐Induced Emission Luminogen
Gu, M., Jiang, S., Xu, X., Wu, M., Chen, C., Yuan, Y., Chen, Q., Sun, Y., Chen, L., Shen, C., et al. (2022) · Advanced Science · doi:10.1002/advs.202106071 · Cited by 44
Two-Dimensional Fluorescence Difference Gel Electrophoretic Analysis ofStreptococcusmutansBiofilms
Rathsam, C., Eaton, R. E., Simpson, C. L., Browne, G. V., Valova, V. A., Harty, D. W. S., & Jacques, N. A. (2005) · Journal of Proteome Research · doi:10.1021/pr0502471 · Cited by 44
Microbial Indicators of Dental Health, Dysbiosis, and Early Childhood Caries
Kahharova, D., Pappalardo, V. Y., Buijs, M., de Menezes, R. D., Peters, M., Jackson, R., Hara, A., Eckert, G., Katz, B., Keels, M., et al. (2023) · Journal of dentistry research · doi:10.1177/00220345231160756 · Cited by 38
Genotypic diversity of Streptococcus mutans and Streptococcus sobrinus in 3-4-year-old children with severe caries or without caries
Zhou, Q., Qin, X., Qin, M., & Ge, L. (2011) · International Journal of Paediatric Dentistry · doi:10.1111/j.1365-263x.2011.01145.x · Cited by 43
Parvimonas micra stimulates expression of gingipains from Porphyromonas gingivalis in multi-species communities
Neilands, J., Davies, J. R., Bikker, F. J., & Svensäter, G. (2018) · Anaerobe · doi:10.1016/j.anaerobe.2018.10.007 · Cited by 43
The evolutionary history of the human oral microbiota and its implications for modern health
Weyrich, L. S. (2020) · Periodontology 2000 · doi:10.1111/prd.12353 · Cited by 45
The quorum quenching enzyme Aii20J modifies in vitro periodontal biofilm formation
Parga, A., Muras, A., Otero‐Casal, P., Arredondo, A., Soler‐Ollé, A., Àlvarez, G., Alcaraz, L. D., Mira, Á., Blanc, V., & Otero, A. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1118630 · Cited by 45
Temporal Relationship between Sucrose-Associated Changes in Dental Biofilm Composition and Enamel Demineralization
Vale, G. C., Tabchoury, C. P. M., Arthur, R. A., Cury, A. A. D. B., Leme, A. F. P., & Cury, J. A. (2007) · Caries Research · doi:10.1159/000105764 · Cited by 42
Transient acid‐impairment of growth ability of oral Streptococcus, Actinomyces, and Lactobacillus: a possible ecological determinant in dental plaque
Horiuchi, M., Washio, J., Mayanagi, H., & Takahashi, N. (2009) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2009.00517.x · Cited by 42
Removal of Dental Biofilms with an Ultrasonically Activated Water Stream
Howlin, R. P., Fabbri, S., Offin, D. G., Symonds, N., Kiang, K. S., Knee, R. J., Yoganantham, D., Webb, J. S., Birkin, P. R., Leighton, T. G., et al. (2015) · Journal of Dental Research · doi:10.1177/0022034515589284 · Cited by 42
Root Surface Biofilms and Caries
Do, T., Damé‐Teixeira, N., Naginyte, M., & Marsh, P. D. (2017) · Monographs in oral science · doi:10.1159/000479304 · Cited by 42
Self-citation
An in vitro investigation of Lactococcus lactis antagonizing cariogenic bacterium Streptococcus mutans
Tong, Z., Zhou, L., Li, J., Kuang, R., Lin, Y., & Ni, L. (2011) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2011.10.003 · Cited by 41
Lactoferrin
Fine, D. H. (2015) · Journal of Dental Research · doi:10.1177/0022034515577413 · Cited by 44
The Danger Signal Extracellular ATP Is an Inducer of Fusobacterium nucleatum Biofilm Dispersal
Ding, Q., & Tan, K. S. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00155 · Cited by 43
Genotypic diversity and phenotypic traits of Streptococcus mutans isolates and their relation to severity of early childhood caries
Valdez, R. M. A., Duque, C., Caiaffa, K. S., dos Santos, V. R., Loesch, M. L. D. A., Colombo, N. H., Arthur, R. A., Negrini, T. D. C., Boriollo, M. F. G., & Delbem, A. C. B. (2017) · BMC Oral Health · doi:10.1186/s12903-017-0406-1 · Cited by 41
Comparative gene expression analysis of planktonic Porphyromonas gingivalis ATCC 33277 in the presence of a growing biofilm versus planktonic cells
Sánchez, M. C., Romero-Lastra, P. T., Ribeiro‐Vidal, H., Llama‐Palacios, A., Figuero, E., Herrera, D., & Sanz, M. (2019) · BMC Microbiology · doi:10.1186/s12866-019-1423-9 · Cited by 42
Cross Talk between Synthetic Food Colors (Azo Dyes), Oral Flora, and Cardiovascular Disorders
John, A., Yang, H., Muhammad, S., Khan, Z. I., Yu, H., Luqman, M., Tufail, M., Hussain, M. I., & Awan, M. U. F. (2022) · Applied Sciences · doi:10.3390/app12147084 · Cited by 41
Characterization of an α- l -fucosidase from the periodontal pathogenTannerella forsythia
Megson, Z. A., Koerdt, A., Schuster, H., Ludwig, R., Janesch, B., Frey, A. M., Naylor, K. L., Wilson, I., Stafford, G. P., Messner, P., et al. (2015) · Virulence · doi:10.1080/21505594.2015.1010982 · Cited by 43
The importance of oral health in (frail) elderly people - a review
van der Putten, G., Visschere, L. D., van der Maarel-Wierink, C. D., Vanobbergen, J., & Schols, J. (2013) · European Geriatric Medicine · doi:10.1016/j.eurger.2013.07.007 · Cited by 44
Red Wine and Oenological Extracts Display Antimicrobial Effects in an Oral Bacteria Biofilm Model
Muñoz‐González, I., Thurnheer, T., Bartolomé, B., & Moreno-Arribas, M. V. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf501768p · Cited by 41
Anti-inflammatory and antimicrobial effects of Zingiber officinale mouthwash on patients with fixed orthodontic appliances
Faria, T. R. B., de Goés, V. F. F., Franzini, C. M., de Aro, A. A., de Andrade, T. A. M., Sartoratto, A., & de Menezes, C. C. (2020) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2019.10.025 · Cited by 40
Role of VltAB, an ABC Transporter Complex, in Viologen Tolerance in Streptococcus mutans
Biswas, S., & Biswas, I. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01094-10 · Cited by 39
Association between khat chewing and gastrointestinal disorders: a cross sectional study.
Nigussie, T., Gobena, T., & Mossie, A. (2013) · Europe PMC (PubMed Central) · Cited by 40
Effect of Lactobacillus species on Streptococcus mutans biofilm formation.
Ahmed, A., Wu, D., Lei, Z., Liu, J., Juanjuan, Q., & Xin, Y. (2014) · PubMed · Cited by 40
Characterization of biofilm formed by multidrug resistant Pseudomonas aeruginosa DC-17 isolated from dental caries
Wu, X., Farraj, D. A. A., Rajaselvam, J., Alkufeidy, R. M., Vijayaraghavan, P., Alkubaisi, N. A. O., Agastian, P., & Alshammari, M. K. (2020) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.07.020 · Cited by 40
The potential of Streptococcus salivarius oral films in the management of dental caries: An inkjet printing approach
Dodoo, C. C., Stapleton, P. D., Basit, A. W., & Gaisford, S. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119962 · Cited by 40
Analysis of the Activity to Induce Toll‐Like Receptor (TLR)2‐ and TLR4‐Mediated Stimulation of Supragingival Plaque
Yoshioka, H., Yoshimura, A., Kaneko, T., Golenbock, D. T., & Hara, Y. (2008) · Journal of Periodontology · doi:10.1902/jop.2008.070516 · Cited by 40
Microbiology of Apical Periodontitis
Siqueira, J. F., Jr., & Rôças, I. N. (2019) · Wiley eBooks · doi:10.1002/9781119272014.ch4 · Cited by 39
Role of bacteria in leukocyte adhesion deficiency-associated periodontitis
Hajishengallis, G., & Moutsopoulos, N. M. (2015) · Microbial Pathogenesis · doi:10.1016/j.micpath.2015.09.003 · Cited by 39

Authors: Marsh, P. D.
Affiliations: Research Division, Centre for Applied Microbiology and Research, Salisbury SP4 0JG, and Division of Oral Biology, Leeds Dental Institute, Clarendon Way, Leeds LS2 9LU, UK
Corresponding author: Marsh, P. D.
ORCID: Marsh, P. D.
Venue: Microbiology
Publisher: Microbiology Society
Published: 2003-02-01
Volume: 149
Issue: 2
Pages: 279-294
ISSN: 1350-0872 (ISSN-L)
1465-2080
DOI: 10.1099/mic.0.26082-0
OpenAlex: W2098976315
Cited by: 1,256
References: 105
Citations by year: 2026: 40 · 2025: 54 · 2024: 56 · 2023: 50 · 2022: 74 · 2021: 79 · 2020: 63 · 2019: 76 · 2018: 58 · 2017: 76 · 2016: 75 · 2015: 81 · 2014: 83 · 2013: 57 · 2012: 54
FWCI: 24.21
Type: journal article
Language: en
Open access: closed
Locations: Microbiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
Keywords: dental plaque, oral microbiota, dental caries, periodontal disease, mutans streptococci, lactobacilli, Gram-negative anaerobic bacteria, acidogenic bacteria, microbial community dynamics, disease prevention, oral microbiology
MeSH terms: Bacteria, Anaerobic, Dental Plaque, Gram-Negative Anaerobic Bacteria, Gram-Positive Bacteria, Homeostasis, Humans, Mouth, Periodontal Diseases, Tooth Diseases, Ecosystem

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Are dental diseases examples of ecological catastrophes?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks