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PreprintCited by 14Neuroscience and Neuropharmacology ResearchCellular Mechanics and InteractionsProtein Structure and Dynamics

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The MeshCODE to scale – Visualising synaptic binary information

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Barnett, Samuel F H, Goult, Benjamin T·2022·Frontiers in Cellular Neuroscience
DOI 10.1101/2022.06.16.496395PMC PMC9716431

Preprint — published as 10.3389/fncel.2022.1014629

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Abstract

The Mercator projection map of the world provides a useful, but distorted, view of the relative scale of countries. Current cellular models suffer from a similar distortion. Here, we undertook an in-depth structural analysis of the molecular dimensions in the cell’s computational machinery, the MeshCODE, that is assembled from a meshwork of binary switches in the scaffolding proteins talin and vinculin. Talin contains a series of force-dependent binary switches and each domain switching state introduces quantised step-changes in talin length on a micrometre scale. The average dendritic spine is 1 µm in diameter so this analysis identifies a plausible Gearbox-like mechanism for dynamic regulation of synaptic function, whereby the positioning of enzymes and substrates relative to each other, mechanically-encoded by the MeshCODE switch patterns, might control synaptic transmission. Based on biophysical rules and experimentally derived distances, this analysis yields a novel perspective on biological digital information.

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Metadata

Authors
Barnett, S. F. H., & Goult, B. T.
Affiliations
  • Max Planck Institute for Medical Research (DE)
  • University of Kent (GB)
Corresponding author
Goult, Benjamin T
ORCID
Venue
Frontiers in Cellular Neuroscience
Publisher
openRxiv
Published
2022-06-17
Volume
16
Pages
1014629-1014629
ISSN
1662-5102 (ISSN-L)
DOI
10.1101/2022.06.16.496395
PMC
PMC9716431
OpenAlex
W4309284852
Cited by
14
References
1
Citations by year
2026: 1 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 1
FWCI
1.44
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Kent Academic Repository (University of Kent) (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • Cancer Research UK (A21671, BB/S007245/1, CRUK-A21671)
  • Directorate for Biological Sciences
  • Biotechnology and Biological Sciences Research Council (BB/S007245/1)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Keywords
talin, vinculin, binary switch, synaptic transmission, dendritic spines, scaffold proteins, molecular dimensions

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