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PreprintCited by 14Developmental Biology and Gene RegulationPlanarian Biology and ElectrostimulationRetinal Development and Disorders

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

A new genetically tractable non-vertebrate system to study complete camera-type eye regeneration

Open access
Accorsi, Alice, Pardo, Brenda, Ross, Eric, Corbin, Timothy J., McClain, Melainia, Weaver, Kyle, Delventhal, Kym, Morrison, Jason A., McKinney, Mary Cathleen, McKinney, Sean A., Sánchez Alvarado, Alejandro·2024·Nature Communications
DOI 10.1101/2024.01.26.577494PMC PMC12328594

Preprint — published as 10.1038/s41467-025-61681-6 · Paper page

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Abstract

Camera-type eyes are complex sensory organs susceptible to irreversible damage. Their repair is difficult to study due to the paucity of camera-type eye regeneration models. Identifying a genetically tractable organism with the ability to fully regenerate complete camera-type eyes would help overcome this difficulty. Here, we introduce the apple snail Pomacea canaliculata , capable of full regeneration of camera-type eyes even after complete resection. We defined anatomical components of P. canaliculata eyes and genes expressed during crucial steps of their regeneration. By exploiting the unique features of this organism, we successfully established the first stable mutant lines in apple snails. Our studies revealed that, akin to humans, pax6 is indispensable for eye development in apple snails, establishing this as a research organism to unravel the mechanisms of camera-type eye regeneration. This work expands our understanding of complex sensory organ regeneration and offers new ways to explore this process.

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Metadata

Authors
Accorsi, A., Pardo, B., Ross, E., Corbin, T. J., McClain, M., Weaver, K., Delventhal, K., Morrison, J. A., McKinney, M. C., McKinney, S. A., & Sánchez Alvarado, A.
Affiliations
Stowers Institute for Medical Research (US)
Corresponding author
Accorsi, Alice
ORCID
Venue
Nature Communications
Publisher
openRxiv
Published
2024-01-27
Volume
16
Issue
1
Pages
6698-6698
ISSN
2041-1723 (ISSN-L)
DOI
10.1101/2024.01.26.577494
PMC
PMC12328594
OpenAlex
W4413025412
Cited by
14
References
1
Citations by year
2026: 6 · 2025: 5 · 2024: 3
FWCI
3.29
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Nature Communications (publishedVersion, cc-by-nc-nd)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Howard Hughes Medical Institute
  • Stowers Institute for Medical Research
  • Society for Developmental Biology
  • American Association for Anatomy
  • University of California, Davis
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
  • Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Keywords
Pomacea canaliculata, apple snail, eye development, Pax6, mutant strain, genetic model organisms, eye anatomy
MeSH terms
PAX6 Transcription Factor, Animals, Eye, Regeneration, Snails

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