Onecut factors and Pou2f2 regulate the distribution of V2 interneurons in the mouse developing spinal cord

Harris, Audrey; Masgutova, Gauhar; Collin, Amandine; Toch, Mathilde; Hidalgo-Figueroa, Maria; Jacob, Benvenuto; Corcoran, Lynn M.; Francius, Cédric; Clotman, Frédéric

doi:10.1101/413054

PreprintCited by 2Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital gastrointestinal and neural anomalies

Onecut factors and Pou2f2 regulate the distribution of V2 interneurons in the mouse developing spinal cord

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Harris, Audrey, Masgutova, Gauhar, Collin, Amandine, Toch, Mathilde, Hidalgo-Figueroa, Maria, Jacob, Benvenuto, Corcoran, Lynn M., Francius, Cédric +1 more·2018·bioRxiv (Cold Spring Harbor Laboratory)

DOI 10.1101/413054

Preprint — published as 10.3389/fncel.2019.00184

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Abstract

Acquisition of proper neuronal identity and position is critical for the formation of neural circuits. In the embryonic spinal cord, cardinal populations of interneurons diversify into specialized subsets and migrate to defined locations within the spinal parenchyma. However, the factors that control interneuron diversification and migration remain poorly characterized. Here, we show that the Onecut transcription factors are necessary for proper diversification and distribution of the V2 interneurons in the developing spinal cord. Furthermore, we uncover that these proteins restrict and moderate the expression of spinal isoforms of Pou2f2 , a transcription factor known to regulate B-cell differentiation. By gain- or loss-of-function experiments, we show that Pou2f2 contribute to regulate the position of V2 populations in the developing spinal cord. Thus, we uncovered a genetic pathway that regulates the diversification and the distribution of V2 interneurons during embryonic development. Significance statement: In this study, we identify the Onecut and Pou2f2 transcription factors as regulators of spinal interneuron diversification and migration, two events that are critical for proper CNS development.

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The lateral V2a subgroup diversifies further into subgroups labelled by Shox2 and Maf/onecut family TFs.
“Furthermore, the lateral subgroup appears to diversify further into subgroups that are labelled by Shox2 and Maf/onecut family TFs (Francius et al., 2013; Harris et al., 2018 preprint).”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Harris et al., 2018 preprint

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Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord
Delile, J., Rayon, T., Melchionda, M., Edwards, A., Briscoe, J., & Sagner, A. (2019) · Development · doi:10.1242/dev.173807 · Cited by 356 · see citing works

Authors: Harris, A., Masgutova, G., Collin, A., Toch, M., Hidalgo-Figueroa, M., Jacob, B., Corcoran, L. M., Francius, C., & Clotman, F.
Affiliations: UCLouvain (BE)
Walter and Eliza Hall Institute of Medical Research (AU)
ORCID: Collin, Amandine
Corcoran, Lynn M.
Clotman, Frédéric
Venue: bioRxiv (Cold Spring Harbor Laboratory)
Publisher: openRxiv
Published: 2018-09-10
DOI: 10.1101/413054
OpenAlex: W2891995326
Cited by: 2
References: 70
Citations by year: 2019: 2
Type: posted content
Language: en
Open access: green
doi.org
Locations: bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
Funders: Association Belge contre les Maladies Neuro-Musculaires
Australian Government
Fonds De La Recherche Scientifique - FNRS (T.0117.13, U.N027.14)
Fédération Wallonie-Bruxelles (10/15-026)
Fonds Spéciaux de Recherche
National Health and Medical Research Council (575500, 637306)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
Keywords: POU2F2, spinal cord development, interneuron migration, neuronal identity, transcriptional regulation, mouse embryo

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Onecut factors and Pou2f2 regulate the distribution of V2 interneurons in the mouse developing spinal cord

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