Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position
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Motor behaviors such as walking or withdrawing the limb from a painful stimulus rely upon integrative multimodal sensory circuitry to generate appropriate muscle activation patterns. Both the cellular components and the molecular mechanisms that instruct the assembly of the spinal sensorimotor system are poorly understood. Here we characterize the connectivity pattern of a sub-population of lamina V inhibitory sensory relay neurons marked during development by the nuclear matrix and DNA binding factor Satb2 (ISR(Satb2)). ISR(Satb2) neurons receive inputs from multiple streams of sensory information and relay their outputs to motor command layers of the spinal cord. Deletion of the Satb2 transcription factor from ISR(Satb2) neurons perturbs their cellular position, molecular profile, and pre- and post-synaptic connectivity. These alterations are accompanied by abnormal limb hyperflexion responses to mechanical and thermal stimuli and during walking. Thus, Satb2 is a genetic determinant that mediates proper circuit development in a core sensory-to-motor spinal network.
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The mid inhibitory cell types were grouped as one family comprising Inhib-15, Inhib-16, Inhib-17, Inhib-18, Inhib-19, Inhib-20, and Inhib-21, which expressed Slc6a5 (except Inhib-21) and Gad2, implicating these neurons in sensorimotor processing.
“The mid inhibitory cell types were grouped as one family comprised of Inhib-15, Inhib-16, Inhib-17, Inhib-18, Inhib-19, Inhib-20, and Inhib-21, which expressed the glycinergic marker Slc6a5 (with the exception of Inhib-21) and also the gaba-ergic marker Gad2, implicating these neurons in sensorimotor processing84–86.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [84]
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FGF and MafB regulated cadherin expression drives lamina formation in the auditory hindbrainPreprint
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- Authors
- Hilde, K. L., Levine, A. J., Hinckley, C. A., Hayashi, M., Montgomery, J. M., Gullo, M., Driscoll, S. P., Grosschedl, R., Kohwi, Y., Kohwi-Shigematsu, T., & Pfaff, S. L.
- Affiliations
- Salk Institute for Biological Studies (US)
- Max Planck Institute of Immunobiology and Epigenetics (DE)
- University of California, San Francisco (US)
- Corresponding author
- Pfaff, Samuel L.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 91
- Issue
- 4
- Pages
- 763-776
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5011456
- OpenAlex
- W2502801262
- Cited by
- 43
- References
- 61
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 8 · 2020: 1 · 2019: 10 · 2018: 5 · 2017: 4 · 2016: 1
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Cancer Institute (R37CA039681, P30CA014195)
- National Institute of Neurological Disorders and Stroke (P30NS072031)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- SATB2, spinal cord development, lamina V, inhibitory interneurons, sensorimotor integration, limb position, nociception, walking, neural circuit assembly, transcription factor deletion
- MeSH terms
- Animals, Extremities, Interneurons, Mutation, Neural Pathways, Pain, Sensory Receptor Cells, Reflex, Spinal Cord, Transcription Factors, Walking, Mice, Knockout, Matrix Attachment Region Binding Proteins, Mice
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