The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling
Open accessAbstract
The epithelial-mesenchymal transition is essential in both embryonic development and the progression of carcinomas. Wnt signaling and cadherin-mediated adhesion have been implicated in both processes; clarifying their role will depend on linking them to rearrangements of cellular structure and behavior. beta-Catenin is an essential molecule both in cadherin-mediated cell adhesion and in canonical Wnt signaling. Numerous experiments have shown that the loss of cadherin-mediated cell adhesion can promote beta-catenin release and signaling; this is accomplished by proteases, protein kinases and other molecules. Cadherin loss can also signal to several other regulatory pathways. Additionally, many target genes of Wnt signaling influence cadherin adhesion. The most conspicuous of these Wnt target genes encode the transcription factors Twist and Slug, which directly inhibit the E-cadherin gene promoter. Other Wnt/beta-catenin target genes encode metalloproteases or the cell adhesion molecule L1, which favor the degradation of E-cadherin. These factors provide a mechanism whereby cadherin loss and increased Wnt signaling induce epithelial-mesenchymal transition in both carcinomas and development.
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Cites
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Self-citationWNT and β-catenin signalling: diseases and therapies
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Cited by
The many faces and functions of β‐catenin
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Loh, C.-Y., Chai, J., Tang, T., Wong, W., Sethi, G., Shanmugam, M., Chong, P., & Looi, C. (2019) · Cells · doi:10.3390/cells8101118 · Cited by 1,315
The functional activity of E-cadherin controls tumor cell metastasis at multiple steps
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The Role of Wnt Signaling in Physiological and Pathological Angiogenesis
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Metadata
- Authors
- Heuberger, J., & Birchmeier, W.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-09-02
- Volume
- 2
- Issue
- 2
- Pages
- a002915-a002915
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2097946485
- Cited by
- 619
- References
- 12
- Type
- posted content
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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