The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Not Just Fat: The Structure and Function of the Lipid Droplet
Open accessAbstract
Lipid droplets (LDs) are independent organelles that are composed of a lipid ester core and a surface phospholipid monolayer. Recent studies have revealed many new proteins, functions, and phenomena associated with LDs. In addition, a number of diseases related to LDs are beginning to be understood at the molecular level. It is now clear that LDs are not an inert store of excess lipids but are dynamically engaged in various cellular functions, some of which are not directly related to lipid metabolism. Compared to conventional membrane organelles, there are still many uncertainties concerning the molecular architecture of LDs and how each function is placed in a structural context. Recent findings and remaining questions are discussed.
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Citations
Cites
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
α-Synuclein Is Degraded by Both Autophagy and the Proteasome
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Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis
Yen, C.-L. E., Stone, S. J., Koliwad, S., Harris, C., & Farese, R. V. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800018-jlr200 · Cited by 1,105
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Zechner, R., Kienesberger, P. C., Haemmerle, G., Zimmermann, R., & Lass, A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800031-jlr200 · Cited by 576
Lipid droplets: A dynamic organelle moves into focus
Beller, M., Thiel, K., Thul, P. J., & Jäckle, H. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.03.022 · Cited by 263
Evolutionarily conserved gene family important for fat storage
Kadereit, B., Kumar, P., Wang, W.-J., Miranda, D., Snapp, E. L., Severina, N., Torregroza, I., Evans, T., & Silver, D. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708579105 · Cited by 252
Starving Neurons Show Sex Difference in Autophagy
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Cited by
The biophysics and cell biology of lipid droplets
Thiam, A. R., Farese Jr, R. V., & Walther, T. C. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3699 · Cited by 986
Wilfling, F., Wang, H., Haas, J. T., Krahmer, N., Gould, T. J., Uchida, A., Cheng, J.-X., Graham, M., Christiano, R., Fröhlich, F., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.01.013 · Cited by 806
Lipophagy: Connecting Autophagy and Lipid Metabolism
Singh, R., & Cuervo, A. M. (2012) · International Journal of Cell Biology · doi:10.1155/2012/282041 · Cited by 497
Reduced Expression of MYC Increases Longevity and Enhances Healthspan
Hofmann, J. W., Zhao, X., De Cecco, M., Peterson, A. L., Pagliaroli, L., Manivannan, J., Hubbard, G. B., Ikeno, Y., Zhang, Y., Feng, B., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.016 · Cited by 293
Mitochondrial and cellular mechanisms for managing lipid excess
Aon, M. A., Bhatt, N., & Cortassa, S. C. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00282 · Cited by 253
“The model also postulates membrane fusion-mediated reorganization of intra-mitochondrial membrane and molecular components (Walther and Farese, 2009) as well as lipids segregation within the droplet (Fujimoto and Parton, 2011).”
Background
Metadata
- Authors
- Fujimoto, T., & Parton, R. G.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-01-26
- Volume
- 3
- Issue
- 3
- Pages
- a004838-a004838
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2041506421
- Cited by
- 484
- References
- 7
- Type
- posted content
- Language
- en
- Open access
- bronze
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