An Overview of MYC and Its Interactome

The landscape of somatic copy-number alteration across human cancers

Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Lovén, J., Hoke, H. A., Lin, C. Y., Lau, A., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.036 · Cited by 2,961

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Delmore, J. E., Issa, G. C., Lemieux, M. E., Rahl, P. B., Shi, J., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.017 · Cited by 2,888

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

Murre, C., Page-McCaw, P., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90682-x · Cited by 2,713

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

Brodeur, G. M., Seeger, R. C., Schwab, M., VARMUS, H. E., & Bishop, J. M. (1984) · Science · doi:10.1126/science.6719137 · Cited by 2,261

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

Kelly, K., Cochran, B., Stiles, C. D., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90092-2 · Cited by 2,227

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 2×

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., et al. (2011) · Nature · doi:10.1038/nature10334 · Cited by 1,870

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

Adams, J. M., Harris, A. W., Pinkert, C. A., Corcoran, L. M., Alexander, W. S., Cory, S., Palmiter, R. D., & Brinster, R. L. (1985) · Nature · doi:10.1038/318533a0 · Cited by 1,779

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

Dalla‐Favera, R., Bregni, M., Erikson, J., Patterson, D., Gallo, R. C., & Croce, C. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7824 · Cited by 1,764

HECTD3 promotes gastric cancer progression by mediating the polyubiquitination of c-MYC

Zhang, G., Zhu, Q., Yan, X., Ci, M., Zhao, E., Hou, J., Wan, S., Lü, M., & Cui, H. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01001-9 · Cited by 19

When Just One Phosphate Is One Too Many: The Multifaceted Interplay between Myc and Kinases

Boi, D., Rubini, E., Breccia, S., Guarguaglini, G., & Paiardini, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054746 · Cited by 20

Development of a Time-Resolved Fluorescence Resonance Energy Transfer Ultrahigh-Throughput Screening Assay for Targeting the NSD3 and MYC Interaction

Xiong, J., González-Pecchi, V., Qui, M., Ivanov, A. A., Mo, X., Niu, Q., Chen, X. '., Fu, H., & Du, Y. (2018) · Assay and Drug Development Technologies · doi:10.1089/adt.2017.835 · Cited by 19

miR-142-5p and miR-212-5p cooperatively inhibit the proliferation and collagen formation of cardiac fibroblasts by regulating c-Myc/TP53INP1

Wang, Z., Fu, M., & Li, Y. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2019-0495 · Cited by 19

Lysine-Specific Demethylase 1 (LSD1/KDM1A) Is a Novel Target Gene of c-Myc

Nagasaka, M., Tsuzuki, K., Ozeki, Y., Tokugawa, M., Ohoka, N., Inoue, Y., & Hayashi, H. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00892 · Cited by 19

The Functional Interaction Between Epstein–Barr Virus and MYC in the Pathogenesis of Burkitt Lymphoma

Solares, S., León, J., & García-Gutiérrez, L. (2024) · Cancers · doi:10.3390/cancers16244212 · Cited by 18

Differential regulation of myc homologs by Wnt/β‐Catenin signaling in the early metazoan Hydra

Hartl, M., Glasauer, S. M. K., Gufler, S., Raffeiner, A., Puglisi, K., Breuker, K., Bister, K., & Hobmayer, B. (2019) · FEBS Journal · doi:10.1111/febs.14812 · Cited by 18

The Multiple Faces of MNT and Its Role as a MYC Modulator

Liaño-Pons, J., Arsenian‐Henriksson, M., & León, J. (2021) · Cancers · doi:10.3390/cancers13184682 · Cited by 17

FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells

Zheng, Y., Dubois, W., Benham, C. J., Batchelor, E., & Levens, D. (2020) · Communications Biology · doi:10.1038/s42003-020-01264-x · Cited by 17

ERK2 stimulates MYC transcription by anchoring CDK9 to the MYC promoter in a kinase activity–independent manner

Agudo‐Ibáñez, L., Morante, M., García-Gutiérrez, L., Quintanilla, A., Rodríguez, J., Múñoz, A., León, J., & Crespo, P. (2023) · Science Signaling · doi:10.1126/scisignal.adg4193 · Cited by 17

Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus

Tregub, P. P., Komleva, Y. K., Kukla, M. V., Сергеевич, А. А., Vetchinova, A. S., Rozanova, N. A., Illarioshkin, S. N., & Salmina, A. B. (2025) · Cells · doi:10.3390/cells14020143 · Cited by 22

Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc

Kandela, I. K., Jin, H. Y., Owen, K. A., & Reproducibility Project: Cancer Biology (2015) · eLife · doi:10.7554/elife.07072 · Cited by 17

Targeting G-Quadruplex DNA for Cancer Chemotherapy

Acharya, P. C., & Debbarma, S. (2022) · Current Drug Discovery Technologies · doi:10.2174/1570163819666220214115408 · Cited by 19

Design, Synthesis, and Biological Evaluation of Thieno[3,2-d]pyrimidine Derivatives as the First Bifunctional PI3Kδ Isoform Selective/Bromodomain and Extra-Terminal Inhibitors

Ran, K., Huang, J.-H., Li, Y., Zhang, Y., Hu, H., Wang, Z., Tang, D., Li, H., Xu, Z., & Chen, Z. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02478 · Cited by 17

LINC00239 Interacts with C-Myc Promoter-Binding Protein-1 (MBP-1) to Promote Expression of C-Myc in Esophageal Squamous Cell Carcinoma

Liang, X., Lu, J., Wu, Z., Guo, Y., Shen, S., Liang, J., Dong, Z., & Guo, W. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-1025 · Cited by 16

c-Myc promotes tumor proliferation and anti-apoptosis by repressing p21 in rhabdomyosarcomas

Zhang, J., Song, N., Zang, D., Yu, J., Li, J., Di, W., Guo, R., Zhao, W., & Wang, H. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7101 · Cited by 16

Yeast expression of mammalian Onzin and fungal FCR1 suggests ancestral functions of PLAC8 proteins in mitochondrial metabolism and DNA repair

Daghino, S., Vietro, L. D., Petiti, L., Martino, E. M. D., Dallabona, C., Lodi, T., & Perotto, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-43136-3 · Cited by 16

Histone deacetylase inhibitors differentially regulate c‑Myc expression in retinoblastoma cells

Yu, N. H., Chen, P., Wang, Q., Liang, M., Qiu, J., Zhou, P., Yang, M., Yang, P., Wu, Y., Han, X., et al. (2019) · Oncology Letters · doi:10.3892/ol.2019.11111 · Cited by 16

Phosphorylated Toll-like receptor 3 nuclear translocation in cancer cell promotes metastasis and chemoresistance

Wang, Z., Gu, Y. H., Liu, Y., Wang, Z., Chen, X., Wang, H., Zhang, W., Jin, G., & Cao, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02307-7 · Cited by 15

Pharmacological inactivation of CDK2 inhibits MYC/BCL-XL-driven leukemia in vivo through induction of cellular senescence

Bazzar, W., Bocci, M., Hejll, E., Tabor, V., Hydbring, P., Grandien, A., Alzrigat, M., & Larsson, L. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1855740 · Cited by 15

Immune evasion: An imperative and consequence of MYC deregulation

Krenz, B., Lee, J., Kannan, T., & Eilers, M. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13695 · Cited by 15

Viral Impact in Autoimmune Diseases: Expanding the “X Chromosome–Nucleolus Nexus” Hypothesis

Brooks, W. H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01657 · Cited by 18

The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells

Lafita‐Navarro, M. C., Liaño-Pons, J., Quintanilla, A., Varela, I., Blanco, R. E., Ourique, F., Bretones, G., Aresti, J., Molina, E., Carroll, P. A., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010389 · Cited by 15

Lessons in aging from Myc knockout mouse models

Prochownik, E. V., & Wang, H. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1244321 · Cited by 16

Web of the Extended Myc Network Captures Metabolism for Tumorigenesis

Dang, C. V. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.01.004 · Cited by 14

Gold‐Based Pharmacophore Inhibits Intracellular MYC Protein

Ofori, S., Gukathasan, S., & Awuah, S. G. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202004962 · Cited by 15

c-myc protects mice from ischemia stroke through elevating microRNA-200b-5p-regulated SIRT1 expression

Liu, X., Guo, H., Wang, X. Q., Jiao, H., Li, L., & Zheng, J. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.07.006 · Cited by 14

Nucleoside diphosphate kinase B promotes osteosarcoma proliferation through c-Myc

Li, S.-J., Hu, T., Yuan, T., Cheng, D., & Yang, Q. (2018) · Cancer Biology & Therapy · doi:10.1080/15384047.2017.1416273 · Cited by 14

The long noncoding RNA KCNQ1DN suppresses the survival of renal cell carcinoma cells through downregulating c-Myc

Yang, F., Wu, Q., Zhang, L., Xie, W., Sun, X., Zhang, Y., Wang, L., Dai, Q., Yu, H., Chen, Q., et al. (2019) · Journal of Cancer · doi:10.7150/jca.29280 · Cited by 14

Novel c-Myc–Targeting Compound N, N-Bis (5-Ethyl-2-Hydroxybenzyl) Methylamine for Mediated c-Myc Ubiquitin-Proteasomal Degradation in Lung Cancer Cells

Sriratanasak, N., Petsri, K., Laobuthee, A., Wattanathana, W., Vinayanuwattikun, C., Luanpitpong, S., & Pithi Chanvorachote, B. (2020) · Molecular Pharmacology · doi:10.1124/mol.120.119719 · Cited by 14

Functional inhibition of c-Myc using novel inhibitors identified through “hot spot” targeting

Singh, A. K., Kumar, P., Sarvagalla, S., Bharadwaj, T., Nayak, N., Coumar, M. S., Giri, R., & Garg, N. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101898 · Cited by 14

The c-Myc targeting hnRNPAB promotes lung adenocarcinoma cell proliferation via stabilization of CDK4 mRNA

Chen, X., Li, B., Yu, N., Yao, B., Wang, F., & Mei, Y. (2023) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2023.106372 · Cited by 13

Manipulating Myc for reparative regeneration

Ascanelli, C., Dahir, R., & Wilson, C. H. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1357589 · Cited by 15

Directly Suppressing MYC Function with Novel Alkynyl-Substituted Phenylpyrazole Derivatives that Induce Protein Degradation and Perturb MYC/MAX Interaction

Zhao, C., Zhao, F., Yang, L., Wang, Y., Wang, H., Fang, F., Zuo, H., Li, Z., He, G., Zhan, W., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00272 · Cited by 13

Inhibition of MUC1-C entering nuclear suppresses MYC expression and attenuates malignant growth in esophageal squamous cell carcinoma

Xin, Z., Gongsun, X., Shi, M., Song, L., Wang, Q., Jiang, B., & Liu, X. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s168813 · Cited by 13

TXNIP loss expands Myc-dependent transcriptional programs by increasing Myc genomic binding

Lim, T.-Y., Wilde, B. R., Thomas, M. L., Murphy, K. E., Vahrenkamp, J. M., Conway, M. E., Varley, K. E., Gertz, J., & Ayer, D. E. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3001778 · Cited by 13

Destruction of a Microtubule-Bound MYC Reservoir during Mitosis Contributes to Vincristine's Anticancer Activity

Becker, S., Kiecke, C., Schäfer, E., Sinzig, U., Deuper, L., Trigo‐Mouriño, P., Griesinger, C., Koch, R., Rydzyńska, Z., Chapuy, B., et al. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-1203 · Cited by 13

Synthetic molecules for disruption of the MYC protein-protein interface

Jacob, N. T., Miranda, P. O., Shirey, R. J., Gautam, R., Zhou, B., de Orbe, M. E., Hixon, M. S., Hart, J. R., Ueno, L. A., Vogt, P. K., et al. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.07.019 · Cited by 12

Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers

Savva, C., DeSouza, K., Ali, R., Rakha, E. A., Green, A. R., & Madhusudan, S. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-05113-8 · Cited by 13

Multifaceted behavior of PEST sequence enriched nuclear proteins in cancer biology and role in gene therapy

Sarfraz, M., Afzal, A., Khattak, S., Saddozai, U. A. K., Li, H., Zhang, Q., Madni, A., Haleem, K. S., Duan, S., Wu, D., et al. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30011 · Cited by 14

Inchworm stepping of Myc-Max heterodimer protein diffusion along DNA

Dai, L., & Yu, J. H. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.08.004 · Cited by 12

A Switch between Two Intrinsically Disordered Conformational Ensembles Modulates the Active Site of a Basic-Helix–Loop–Helix Transcription Factor

Sicoli, G., Kress, T., Vezin, H., Ledolter, K., & Kurzbach, D. (2020) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.0c02242 · Cited by 13

CSNK2A1-mediated MAX phosphorylation upregulates HMGB1 and IL-6 expression in cholangiocarcinoma progression

Yang, B., Zhang, J., Wang, J., Fan, W., Barbier‐Torres, L., Yang, X., Justo, M., Liu, T., Chen, Y., Steggerda, J. A., et al. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000144 · Cited by 13

Rewired Metabolism Caused by the Oncogenic Deregulation of MYC as an Attractive Therapeutic Target in Cancers

Vízkeleti, L., & Spisák, S. (2023) · Cells · doi:10.3390/cells12131745 · Cited by 10

Identification of antimycin A as a c-Myc degradation accelerator via high-throughput screening

Liu, Z., Ishikawa, K., Sanada, E., Semba, K., Li, J., Li, X., Osada, H., & Watanabe, N. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105083 · Cited by 11

Real-Time Measurement of a Weak Interaction of a Transcription Factor Motif with a Protein Hub at Single-Molecule Precision

Mayse, L. A., Wang, Y., Ahmad, M., & Movileanu, L. (2024) · ACS Nano · doi:10.1021/acsnano.4c04857 · Cited by 13

Perspectives on drug discovery strategies based on IDPs

Fuertes, G., Nevola, L., & Esteban-Martín, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816348-1.00009-0 · Cited by 11

Transcriptional regulation of MYC through G-quadruplex structures

Balaratnam, S., & Schneekloth, J. S. (2020) · Annual reports in medicinal chemistry · doi:10.1016/bs.armc.2020.05.002 · Cited by 12

Behavioral Changes in Stem-Cell Potency by HepG2-Exhausted Medium

Balzano, F., Garroni, G., Cruciani, S., Bellu, E., Giudici, S. D., Oggiano, A., Capobianco, G., Dessole, S., Ventura, C., & Maioli, M. (2020) · Cells · doi:10.3390/cells9081890 · Cited by 11

Computational study on natural compounds inhibitor of c-Myc

Ren, J., Huangfu, Y., Ge, J., Wu, B., Li, W., Wang, X., & Zhao, L. (2020) · Medicine · doi:10.1097/md.0000000000023342 · Cited by 11

The new role for an old guy: MYC as an immunoplayer

Marinković, D., & Marinković, T. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30123 · Cited by 12

MYC directly transactivates CR2/CD21, the receptor of the Epstein–Barr virus, enhancing the viral infection of Burkitt lymphoma cells

Molina, E., García-Gutiérrez, L., Junco, V., Pérez‐Olivares, M., de Yébenes, V. G., Blanco, R. E., Quevedo, L., Acosta, J. C., Marín, A. V., Ulgiati, D., et al. (2023) · Oncogene · doi:10.1038/s41388-023-02846-9 · Cited by 10

Regulation of BCR-mediated Ca 2+ mobilization by MIZ1-TMBIM4 safeguards IgG1 + GC B cell–positive selection

Zhang, L., Toboso-Navasa, A., Gunawan, A. S., Camara, A., Nakagawa, R., Finsterbusch, K., Chakravarty, P., Newman, R., Zhang, Y., Eilers, M., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adk0092 · Cited by 10

In vivo CRISPR screens identify Mga as an immunotherapy target in triple-negative breast cancer

Xu, F., Yang, C. Q., Huang, Y., Su, D., Wang, C., Wilson, L., Yin, L., Tang, M., Li, S., Chen, Z., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2406325121 · Cited by 9

KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma

Mihalas, A. B., Arora, S., O’Connor, S. A., Feldman, H. M., Cucinotta, C. E., Mitchell, K., Bassett, J., Kim, D., Jin, K., Hoellerbauer, P., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59503-w · Cited by 10

Predicting interactome network perturbations in human cancer: application to gene fusions in acute lymphoblastic leukemia

Hajingabo, L. J., Daakour, S., Martin, M., Grausenburger, R., Panzer‐Grümayer, R., Dequiedt, F., Simonis, N., & Twizere, J. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-06-1038 · Cited by 10

MYC as therapeutic target in leukemia and lymphoma

León, J., Cortiguera, M. G., Batlle‐López, A., Albajar, M., & Delgado, M. D. (2015) · Blood and Lymphatic Cancer Targets and Therapy · doi:10.2147/blctt.s60495 · Cited by 10

Tracing MYC Expression for Small Molecule Discovery

Steinberger, J., Robert, F., Hallé, M., Williams, D. E., Cencic, R., Sawhney, N., Pelletier, D., Williams, P. G., Igarashi, Y., Porco, J. A. J., et al. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2019.02.007 · Cited by 11

Mycb and Mych stimulate Müller glial cell reprogramming and proliferation in the uninjured and injured zebrafish retina

Lee, M., Jui, J., Sahu, A., & Goldman, D. J. (2024) · Development · doi:10.1242/dev.203062 · Cited by 9

EV20/Omomyc: A novel dual MYC/HER3 targeting immunoconjugate

Bibbò, S., Capone, E., Lovato, G., Ponziani, S., Lamolinara, A., Iezzi, M., Lattanzio, R., Mazzocco, K., Morini, M., Giansanti, F., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.08.009 · Cited by 9

Discovery of a Pyrazolopyridinone-Based MYC Inhibitor That Selectively Engages Intracellular c-MYC and Disrupts MYC–MAX Heterodimerization

Obisesan, O. A., Ofori, S., Orobator, O. N., Sharma, H., Groetecke, E., & Awuah, S. G. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02556 · Cited by 9

Exploring Myc puzzle: Insights into cancer, stem cell biology, and PPI networks

Ghasemi, N., & Azizi, H. (2024) · Gene · doi:10.1016/j.gene.2024.148447 · Cited by 9

High expression of ZNF93 promotes proliferation and migration of ovarian cancer cells and relates to poor prognosis.

Cui, X., Zhou, C., Lu, H., Han, Y., Wang, F., Fan, W., Ren, Y., & Zhang, R. (2020) · PubMed Central · Cited by 9

The UVSSA complex alleviates MYC-driven transcription stress

Sato, M., Liebau, R. C., Liu, Z., Liu, L., Rabadán, R., & Gautier, J. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.201807163 · Cited by 8

MYC Analysis in Cancer and Evolution

Hartl, M., & Bister, K. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1476-1_6 · Cited by 9

Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease

DeVore, S. B., Schuetz, M., Alvey, L., Lujan, H., Ochayon, D. E., Williams, L., Chang, W. C., Filuta, A. L., Ruff, B. P., Kothari, A., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114589 · Cited by 8

Selective Enhancer Gain-of-Function Deregulates MYC Expression in Multiple Myeloma

Rahmat, M., Clement, K., Alberge, J.-B., Sklavenitis‐Pistofidis, R., Kodgule, R., Fulco, C. P., Heilpern-Mallory, D., Nilsson, K., Dorfman, D. M., Engreitz, J., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-1440 · Cited by 10

MXD/MIZ1 transcription regulatory complexes activate the expression of MYC‐repressed genes

Shostak, A., Schermann, G., Diernfellner, A. C. R., & Brunner, M. (2021) · FEBS Letters · doi:10.1002/1873-3468.14097 · Cited by 8

AXL upregulates c‑Myc expression through AKT and ERK signaling pathways in breast cancers

Sun, X., Chen, H., You, S., Tian, Z., Wang, Z., Liu, F., Hu, W., Zhang, H., Zhang, G., Zhao, H., et al. (2023) · Molecular and Clinical Oncology · doi:10.3892/mco.2023.2618 · Cited by 8

c-Myc-induced long noncoding RNA MIRE cooperates with hnRNPK to stabilize ELF2 mRNA and promotes clear cell renal cell carcinogenesis

Li, B., Yao, B., Guo, X., Wang, Z., Xie, W., Wu, X., Wang, F., & Mei, Y. (2023) · Cancer Gene Therapy · doi:10.1038/s41417-023-00631-0 · Cited by 8

Targeting protein synthesis pathways in MYC-amplified medulloblastoma

Kumar, D., Kanchan, R. K., & Chaturvedi, N. K. (2025) · Discover Oncology · doi:10.1007/s12672-025-01761-7 · Cited by 9

Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin

Brandl, L., Hartmann, D., Kirchner, T., & Menssen, A. (2018) · Acta Dermato Venereologica · doi:10.2340/00015555-3031 · Cited by 8

The Novel Artemisinin Dimer Isoniazide ELI-XXIII-98-2 Induces c-MYC Inhibition, DNA Damage, and Autophagy in Leukemia Cells

Elbadawi, M., Boulos, J. C., Dawood, M., Zhou, M., Gul, W., ElSohly, M. A., Klauck, S. M., & Efferth, T. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041107 · Cited by 8

Mitosis and mitochondrial priming for apoptosis

Pedley, R., & Gilmore, A. P. (2016) · Biological Chemistry · doi:10.1515/hsz-2016-0134 · Cited by 8

Silencing of CDK2, but not CDK1, separates mitogenic from anti-apoptotic signaling, sensitizing p53 defective cells for synthetic lethality

Nekova, T. S., Kneitz, S., Einsele, H., Bargou, R. C., & Stuhler, G. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1241915 · Cited by 8

Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism

Hsieh, A. L., Zheng, X., Yue, Z., Stine, Z. E., Mancuso, A., Rhoades, S. D., Brooks, R. C., Weljie, A. M., Eisenman, R. N., Sehgal, A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.022 · Cited by 8

The Diarylheptanoid Curcumin Induces MYC Inhibition and Cross-Links This Oncoprotein to the Coactivator TRRAP

Mödlhammer, A., Pfurtscheller, S., Feichtner, A., Hartl, M., & Schneider, R. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.660481 · Cited by 7

Salvianolic Acid B Noncovalently Interacts With Disordered c-Myc: A Computational and Spectroscopic-Based Study

Singh, A. K., Kumar, A., Kumar, P., Bhardwaj, T., Giri, R., & Garg, N. (2021) · Future Medicinal Chemistry · doi:10.4155/fmc-2021-0087 · Cited by 7

The MYC-regulated lncRNA LNROP (ENSG00000254887) enables MYC-driven cell proliferation by controlling the expression of OCT2

García-Caballero, D., Hart, J. R., & Vogt, P. K. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05683-6 · Cited by 7

Production of Anti-c-Myc Monoclonal Antibody Inhibiting DNA Binding of c-Myc and Max Dimer by Epitope Peptide–CpG-DNA–Liposome Complex Without Carriers

Park, B. K., Gautam, A., Maharjan, S., Lee, S. I., Lee, Y., & Kwon, H. (2017) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-017-9649-6 · Cited by 7

FASTKD2 promotes cancer cell progression through upregulating Myc expression in pancreatic ductal adenocarcinoma

Fang, R., Zhang, B., Lu, X., Jin, X., & Liu, T. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29468 · Cited by 7

Benzofuranyl-pyrazole as a Novel Scaffold for In Vitro and In Vivo Potent Anticancer Therapeutics That Directly Disrupt the ‘Undruggable’ MYC Oncogene and Potentiate Immune Checkpoint Blockage

Yang, L., Zuo, H., Sha, M., Zhan, W., Li, J., Liu, Y., Fang, F., Wang, Y., & Ma, X. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c01307 · Cited by 6

Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay

Shirey, R. J., Hart, J. R., Sridharan, B., Novick, S. J., Turner, L. D., Zhou, B., Nielsen, A. L., Eubanks, L. M., Ueno, L. A., Hixon, M. S., et al. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116246 · Cited by 6

System analysis based on Anoikis-related genes identifies MAPK1 as a novel therapy target for osteosarcoma with neoadjuvant chemotherapy

Wu, Z., Yu, J., Han, T., Tu, Y., Su, F., Li, S., & Huang, Y. (2024) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-024-07547-2 · Cited by 6

The C. elegans Myc-family of transcription factors coordinate a dynamic adaptive response to dietary restriction

Cornwell, A., Zhang, Y., Thondamal, M., Johnson, D. W., Thakar, J., & Samuelson, A. V. (2024) · GeroScience · doi:10.1007/s11357-024-01197-x · Cited by 6

Isolation, characterization, and expression of proto-oncogene cMyc in large yellow croaker Larimichthys crocea

Jiang, Y., Han, K., Chen, S., Wang, Y., & Zhang, Z. (2017) · Fish Physiology and Biochemistry · doi:10.1007/s10695-017-0384-x · Cited by 6

High Intrinsic Oncogenic Potential in the Myc-Box-Deficient Hydra Myc3 Protein

Lechable, M., Tang, X., Siebert, S., Feldbacher, A., Fernández‐Quintero, M. L., Breuker, K., Juliano, C. E., Liedl, K. R., Hobmayer, B., & Hartl, M. (2023) · Cells · doi:10.3390/cells12091265 · Cited by 6

Reciprocal regulation of lncRNA MEF and c-Myc drives colorectal cancer tumorigenesis

Wu, S., Dai, X., Zhu, Z., Fan, D., Jiang, S., Dong, Y., Chen, B., Xie, Q., Yao, Z., Li, Q., et al. (2024) · Neoplasia · doi:10.1016/j.neo.2024.100971 · Cited by 6

Driver or passenger effects of augmented c-Myc and Cdc20 in gliomagenesis

Ji, P., Zhou, X., Liu, Q., Fuller, G. N., Phillips, L. M., & Zhang, W. (2016) · Oncotarget · doi:10.18632/oncotarget.8080 · Cited by 6

Genetic Drivers of Pancreatic Cancer Are Identical Between the Primary Tumor and a Secondary Lesion in a Long-Term (>5 Years) Survivor After a Whipple Procedure

Bauer, T. M., Dhir, T., Strickland, A. G., Thomsett, H. L., Goetz, A. B., Cannaday, S., Brody, J. R., Pishvaian, M. J., & Yeo, C. J. (2018) · Journal of Pancreatic Cancer · doi:10.1089/pancan.2018.0015 · Cited by 6

Investigating In Situ Expression of c-MYC and Candidate Ubiquitin-Specific Proteases in DLBCL and Assessment for Peptidyl Disruptor Molecule against c-MYC-USP37 Complex

Kamran, D. E. S., Hussain, M., & Mirza, T. (2023) · Molecules · doi:10.3390/molecules28062441 · Cited by 6

A History of Cancer Research: Oncogenic Transcription FactorsPreprint

Lipsick, J. S. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a035881 · Cited by 6

C-MYC as a key effector of WNT, PI3K/AKT, MAPK, and TGF-β signaling pathways in regulation of epithelial-mesenchymal transition during tumor metastasis

Moghbeli, M. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04311-5 · Cited by 6

Identification of microbial metabolites that accelerate the ubiquitin-dependent degradation of c-Myc

Liu, Z. L., Okano, A., Sanada, E., Futamura, Y., Nogawa, T., Ishikawa, K., Semba, K., Li, J., Li, X., Osada, H., et al. (2023) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2023.030248 · Cited by 5

Max-imizing the Attenuation of Myc Using Small Molecules

Boyd, S. R., & Young, D. W. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.06.002 · Cited by 5

Co-expression patterns explain how a basic transcriptional role for MYC modulates Wnt and MAPK pathways in colon and lung adenocarcinomas

Kucherlapati, M. H. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2060454 · Cited by 5

FABP6 serves as a new therapeutic target in esophageal tumor

Zhang, D., Zhao, F., Liu, H., Guo, P., Li, Z., & Li, S. (2024) · Aging · doi:10.18632/aging.205448 · Cited by 5

Missense Mutations in Myc Box I Influence Nucleocytoplasmic Transport to Promote Leukemogenesis

Arthur, N. B. J., Christensen, K. A., Mannino, K., Ruzinova, M. B., Kumar, A., Gruszczyńska, A., Day, R. B., Erdmann-Gilmore, P., Mi, Y., Sprung, R. W., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-0926 · Cited by 6

Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes

Wigton, E. J., DeFranco, A. L., & Ansel, K. M. (2019) · ImmunoHorizons · doi:10.4049/immunohorizons.1900030 · Cited by 5

Notch signaling defects in NK cells in patients with cancer

Zakiryanova, G. K., Кустова, Е. А., Urazalieva, N. T., Baimukhametov, E. T., Makarov, V. A., Turaly, G. M., Shurin, G. V., Biyasheva, Z. M., Nakisbekov, N. N., & Shurin, M. R. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02763-w · Cited by 5

Abstract IA01: Myc functions within a transcriptional regulatory network

Eisenman, R. N. (2015) · Molecular Cancer Research · doi:10.1158/1557-3125.myc15-ia01

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Carroll, P. A., Freie, B. W., Mathsyaraja, H., & Eisenman, R. N. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0650-z · Cited by 289

The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

Grandori, C., Cowley, S. M., James, L. P., & Eisenman, R. N. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.653 · Cited by 1,333

Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis

Diolaiti, D., McFerrin, L. G., Carroll, P. A., & Eisenman, R. N. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.05.016 · Cited by 115

The MYC network: Hub of malignancy and blueprint for intervention

Yin, H., Liu, T., & Pan, J. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189651 · Cited by 1