PreprintCited by 66Cytokine Signaling Pathways and InteractionsNF-κB Signaling PathwaysCell death mechanisms and regulation

The Tumor Necrosis Factor Family: Family Conventions and Private Idiosyncrasies

Open access
Wallach, David·2018·Cold Spring Harbor Perspectives in Biology

Abstract

The tumor necrosis factor (TNF) cytokine family and the TNF/nerve growth factor (NGF) family of their cognate receptors together control numerous immune functions, as well as tissue-homeostatic and embryonic-development processes. These diverse functions are dictated by both shared and distinct features of family members, and by interactions of some members with nonfamily ligands and coreceptors. The spectra of their activities are further expanded by the occurrence of the ligands and receptors in both membrane-anchored and soluble forms, by "re-anchoring" of soluble forms to extracellular matrix components, and by signaling initiation via intracellular domains (IDs) of both receptors and ligands. Much has been learned about shared features of the receptors as well as of the ligands; however, we still have only limited knowledge of the mechanistic basis for their functional heterogeneity and for the differences between their functions and those of similarly acting cytokines of other families.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1101/cshperspect.a028431

Cites

179 of 179 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

Research works printed but not linked: 1

  1. Wallach D. 2016b. TNFα. In Encyclopedia of inflammatory diseases (ed. Parnham M). Springer, Basel.

Cited by

Sorted by citations

Authors
Wallach, D.
Affiliations
Weizmann Institute of Science (IL)
Corresponding author
Wallach, David
Venue
Cold Spring Harbor Perspectives in Biology
Published
2017-08-28
Volume
10
Issue
10
Pages
a028431
ISSN
1943-0264 (ISSN-L)
OpenAlex
W2749692273
Cited by
66
References
179
Citations by year
2026: 9 · 2025: 15 · 2024: 12 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 1
Type
posted content
Language
en
Open access
Locations
  • Cold Spring Harbor Perspectives in Biology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
tumor necrosis factor family, TNF receptor, nerve growth factor, cytokine signaling, soluble receptor, cytoplasmic domain, co-receptors, immune regulation, embryonic development, functional heterogeneity
MeSH terms
Animals, Gene Expression Regulation, Multigene Family, Humans, Tumor Necrosis Factor-alpha, Receptor, Nerve Growth Factor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review