The Tumor Necrosis Factor Family: Family Conventions and Private Idiosyncrasies
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The tumor necrosis factor (TNF) cytokine family and the TNF/nerve growth factor (NGF) family of their cognate receptors together control numerous immune functions, as well as tissue-homeostatic and embryonic-development processes. These diverse functions are dictated by both shared and distinct features of family members, and by interactions of some members with nonfamily ligands and coreceptors. The spectra of their activities are further expanded by the occurrence of the ligands and receptors in both membrane-anchored and soluble forms, by "re-anchoring" of soluble forms to extracellular matrix components, and by signaling initiation via intracellular domains (IDs) of both receptors and ligands. Much has been learned about shared features of the receptors as well as of the ligands; however, we still have only limited knowledge of the mechanistic basis for their functional heterogeneity and for the differences between their functions and those of similarly acting cytokines of other families.
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We identified and annotated 61 genes in the muskox MHC Class III region, including members of the TNF family, the Lymphocyte Antigen-6 family members, and the members of the complement cascade.
“We identified and annotated 61 genes in the muskox MHC Class III region, including members of the TNF family123,124, the Lymphocyte Antigen-6 family members125, and the members of the complement cascade.126”
From Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics (2024) · cites this paper as [124]
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Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Wallach D. 2016b. TNFα. In Encyclopedia of inflammatory diseases (ed. Parnham M). Springer, Basel.
Cited by
Sorted by citations
Lok, S., Lau, T. N. H., Trost, B., Tong, A. H. Y., Paton, T., Wintle, R. F., Engstrom, M. D., Gunn, A., & Scherer, S. W. (2024) · Scientific Reports · doi:10.1038/s41598-024-67270-9 · Cited by 4 · see citing works
“We identified and annotated 61 genes in the muskox MHC Class III region, including members of the TNF family 123,124 , the Lymphocyte Anti-gen-6 family members 125 , and the members of the complement cascade.”
Method
- Authors
- Wallach, D.
- Affiliations
- Weizmann Institute of Science (IL)
- Corresponding author
- Wallach, David
- ORCID
- Wallach, David
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2017-08-28
- Volume
- 10
- Issue
- 10
- Pages
- a028431
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC6169814
- OpenAlex
- W2749692273
- Cited by
- 66
- References
- 179
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 12 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- tumor necrosis factor family, TNF receptor, nerve growth factor, cytokine signaling, soluble receptor, cytoplasmic domain, co-receptors, immune regulation, embryonic development, functional heterogeneity
- MeSH terms
- Animals, Gene Expression Regulation, Multigene Family, Humans, Tumor Necrosis Factor-alpha, Receptor, Nerve Growth Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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