The DOI matches its Crossref record; 229 of the 229 references it cites were found in a registry or an index.
Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations
Open accessAbstract
Exercise stimulates the release of proteins with autocrine, paracrine, or endocrine functions produced in skeletal muscle, termed myokines. Based on the current state of knowledge, the major physiological function of myokines is to protect the functionality and to enhance the exercise capacity of skeletal muscle. Myokines control adaptive processes in skeletal muscle by acting as paracrine regulators of fuel oxidation, hypertrophy, angiogenesis, inflammatory processes, and regulation of the extracellular matrix. Endocrine functions attributed to myokines are involved in body weight regulation, low-grade inflammation, insulin sensitivity, suppression of tumor growth, and improvement of cognitive function. Muscle-derived regulatory RNAs and metabolites, as well as the design of modified myokines, are promising novel directions for treatment of chronic diseases.
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“Importantly, it is worth noting that the production of “positive” myokines is as much promoted by physical exercise as it is repressed by physical inactivity, highlighting the importance of lifestyle for healthspan 112.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [112]
In the citing paper
“Alterations in myokine production associated with physical inactivity may also mediate the onset of obesity.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [112]
In the citing paper
“Physical inactivity, that can be both a cause and a consequence of obesity, is known to be associated with decreased insulin sensitivity, reduced postprandial lipid metabolism, decreased muscle mass, and obesity.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [112]
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Metadata
- Authors
- Hoffmann, C., & Weigert, C.
- Affiliations
- Universitätsklinikum Tübingen (DE)
- Helmholtz Munich (DE)
- ORCID
- Weigert, Cora
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2017-04-07
- Volume
- 7
- Issue
- 11
- Pages
- a029793
- ISSN
- 2157-1422 (ISSN-L)
- PMC
- PMC5666622
- OpenAlex
- W2605110590
- Cited by
- 393
- References
- 228
- Citations by year
- 2026: 51 · 2025: 65 · 2024: 54 · 2023: 40 · 2022: 57 · 2021: 44 · 2020: 35 · 2019: 28 · 2018: 15 · 2017: 3
- Type
- posted content
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cold Spring Harbor Perspectives in Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion, other-oa)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (01GI0925)
- Rigshospitalet
- Leibniz-Gemeinschaft (SAW-FBN-2013-3)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- myokines, skeletal muscle endocrine function, exercise adaptation, paracrine signaling, muscle hypertrophy, angiogenesis, extracellular matrix, low-grade inflammation, insulin sensitivity, body weight regulation, tumor suppression, cognitive function, muscle metabolites, chronic disease treatment
- MeSH terms
- Adaptation, Physiological, Chronic Disease, Humans, Exercise, Cytokines, Muscle, Skeletal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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