Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810

The Human Plasma Proteome

Anderson, N. L., & Anderson, N. G. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r200007-mcp200 · Cited by 4,414

Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013

The Extracellular Matrix: Not Just Pretty Fibrils

Hynes, R. O. (2009) · Science · doi:10.1126/science.1176009 · Cited by 3,527

Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases

Pedersen, B. K., & Saltin, B. (2015) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12581 · Cited by 3,514

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272 · cited 1×

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909

The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease

Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3041 · Cited by 2,470

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084

Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading

Kjær, M. (2004) · Physiological Reviews · doi:10.1152/physrev.00031.2003 · Cited by 1,649

Muscle–Organ Crosstalk: The Emerging Roles of Myokines

Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226

Physical activity and muscle-brain crosstalk

Pedersen, B. K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0174-x · Cited by 772

Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease

Pedersen, B. K. (2017) · European Journal of Clinical Investigation · doi:10.1111/eci.12781 · Cited by 617

Effects of Exercise to Improve Cardiovascular Health

Pinckard, K. M., Baskin, K. K., & Stanford, K. I. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00069 · Cited by 517

Exercise and mitochondrial health

Memme, J. M., Erlich, A. T., Phukan, G., & Hood, D. A. (2021) · The Journal of Physiology · doi:10.1113/jp278853 · Cited by 343

FGF21 as Modulator of Metabolism in Health and Disease

Tezze, C., Romanello, V., & Sandri, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00419 · Cited by 319

Molecular Responses to Acute Exercise and Their Relevance for Adaptations in Skeletal Muscle to Exercise Training

Egan, B., & Sharples, A. P. (2023) · Physiological Reviews · doi:10.1152/physrev.00054.2021 · Cited by 278

Systemic impacts of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) on heart, muscle, and kidney related diseases

Sandireddy, R., Sakthivel, S., Gupta, P., Behari, J., Tripathi, M., & Singh, B. K. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1433857 · Cited by 235

Inter‐organ communication: a gatekeeper for metabolic health

Castillo‐Armengol, J., Fajas, L., & Lopez‐Mejia, I. C. (2019) · The EMBO Reports · doi:10.15252/embr.201947903 · Cited by 178

Molecular mechanisms of exercise contributing to tissue regeneration

Chen, J., Zhou, R. J., Ye, F., & Cheng, L. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01233-2 · Cited by 182

The physiology of optimizing health with a focus on exercise as medicine

Pedersen, B. K. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114339 · Cited by 163

Circadian rhythms and cancers: the intrinsic links and therapeutic potentials

Zhou, L., Zhang, Z., Nice, E. C., Huang, C., Zhang, W., & Tang, Y. C. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01238-y · Cited by 160

The JAK/STAT Pathway in Skeletal Muscle Pathophysiology

Moresi, V., Adamo, S., & Berghella, L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00500 · Cited by 145

A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription

Jin, L. G., Tang, Q., Hu, S., Chen, Z., Zhou, X., Zeng, B., Wang, Y., He, M., Li, Y., Gui, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23560-8 · Cited by 140

Engineered skeletal muscles for disease modeling and drug discovery

Wang, J., Khodabukus, A., Rao, L., VanDusen, K. W., Abutaleb, N. O., & Bursac, N. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119416 · Cited by 125

Interleukin-15 facilitates muscle regeneration through modulation of fibro/adipogenic progenitors

Kang, X., Yang, M., Shi, Y., Xie, M., Zhu, M. P., Zheng, X., Zhang, C., Ge, Z., Bian, X., Lv, J.-T., et al. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0251-0 · Cited by 121

Muscle-to-tumor crosstalk: The effect of exercise-induced myokine on cancer progression

Huang, Q., Wu, M., Wu, X., Zhang, Y., & Xia, Y. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188761 · Cited by 124

Muscle-Organ Crosstalk: Focus on Immunometabolism

Bay, M. L., & Pedersen, B. K. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.567881 · Cited by 116

The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2

Lee, J. O., Lee, H. J., Lee, Y. W., Han, J. A., Kang, M. J., Moon, J., Shin, M.-J., Lee, H. J., Chung, J. H., Lee, J., et al. (2020) · FEBS Journal · doi:10.1111/febs.15301 · Cited by 97

Exercise training mode effects on myokine expression in healthy adults: A systematic review with meta-analysis

Bettariga, F., Taaffe, D. R., Galvão, D. A., Lopez, P., Bishop, C., Markarian, A. M., Natalucci, V., Kim, J.-S., & Newton, R. U. (2024) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2024.04.005 · Cited by 83

Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses

Reyes-Furrer, A. A., Andrade, S. D., Bachmann, D., Jeker, H., Steinmann, M., Accart, N., Dunbar, A., Rausch, M., Bono, E., Rimann, M., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02691-0 · Cited by 80

Skeletal muscle releases extracellular vesicles with distinct protein and microRNA signatures that function in the muscle microenvironment

Watanabe, S., Sudo, Y., Makino, T., Kimura, S., Tomita, K., Noguchi, M., Sakurai, H., Shimizu, M., Takahashi, Y., Sato, R., et al. (2022) · PNAS Nexus · doi:10.1093/pnasnexus/pgac173 · Cited by 81

Treadmill Exercise Modulates Intestinal Microbes and Suppresses LPS Displacement to Alleviate Neuroinflammation in the Brains of APP/PS1 Mice

Yuan, S., Yang, J., Jian, Y., Lei, Y., Yao, S., Hu, Z., Liu, X., Tang, C., & Liu, W. (2022) · Nutrients · doi:10.3390/nu14194134 · Cited by 75

The wonder exerkines—novel insights: a critical state-of-the-art review

Magliulo, L., Bondi, D., Pini, N., Marramiero, L., & Filippo, E. S. D. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04264-5 · Cited by 77

Role of Physical Activity in Bone–Muscle Crosstalk: Biological Aspects and Clinical Implications

Cariati, I., Bonanni, R., Onorato, F., Mastrogregori, A., Rossi, D., Iundusi, R., Gasbarra, E., Tancredi, V., & Tarantino, U. (2021) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk6020055 · Cited by 76

New Insights Into the Comorbidity of Coronary Heart Disease and Depression

Wu, Y., Zhu, B., Chen, Z., Duan, J., Luo, A., Yang, L., & Yang, C. (2019) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2019.03.002 · Cited by 72

Current and Future Nutritional Strategies to Modulate Inflammatory Dynamics in Metabolic Disorders

van den Brink, W., van Bilsen, J. H. M., Salic, K., Hoevenaars, F. P. M., Verschuren, L., Kleemann, R., Bouwman, J., Ronnett, G. V., van Ommen, B., & Wopereis, S. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00129 · Cited by 74

Cancer Related Anemia: An Integrated Multitarget Approach and Lifestyle Interventions

Natalucci, V., Virgili, E., Calcagnoli, F., Valli, G., Agostini, D., Zeppa, S. D., Barbieri, E., & Emili, R. (2021) · Nutrients · doi:10.3390/nu13020482 · Cited by 71

The role of glucose homeostasis on immune function in response to exercise: The impact of low or higher energetic conditions

Morano, A. E. V. A., Dorneles, G. P., Peres, A., & Lira, F. S. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29228 · Cited by 63

Functional, proteomic and bioinformatic analyses of Nrf2- and Keap1- null skeletal muscle

Gao, L., Kumar, V., Vellichirammal, N. N., Park, S., Rudebush, T. L., Yu, L., Son, W., Pekas, E. J., Wafi, A. M., Hong, J., et al. (2020) · The Journal of Physiology · doi:10.1113/jp280176 · Cited by 58

Aged Skeletal Muscle Retains the Ability to Remodel Extracellular Matrix for Degradation of Collagen Deposition after Muscle Injury

Chen, W., Lin, I., Lee, C., & Chen, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042123 · Cited by 61

Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases

Marques‐Aleixo, I., Beleza, J., Sampaio, A., Stevanović, J., Coxito, P. M., Gonçalves, I. O., Ascensão, A. A. M. R., & Magalhães, J. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8075 · Cited by 68

State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions

Lavin, K. M., Coen, P. M., Baptista, L. C. P., Bell, M. B., Drummer, D. J., Harper, S. A., Lixandrão, M. E., McAdam, J. S., O’Bryan, S. M., Ramos, S. V., et al. (2022) · Comprehensive physiology · doi:10.1002/cphy.c200033 · Cited by 78

Hepatokines—A novel group of exercise factors

Weigert, C., Hoene, M., & Plomgaard, P. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2216-y · Cited by 57

Irisin and Autophagy: First Update

Pesce, M., Ballerini, P., Paolucci, T., Puca, I., Farzaei, M. H., & Patruno, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207587 · Cited by 59

Tooth Loss, Denture Use, and Cognitive Impairment in Chinese Older Adults: A Community Cohort Study

Yang, H., Li, F., Chen, P., Cheng, X., Mao, C., & Wu, X. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab056 · Cited by 56

Ferroptosis and its role in skeletal muscle diseases

Wang, Y., Zhang, Z., Jiao, W., Wang, Y., Wang, X., Zhao, Y., Fan, X., Tian, L., Li, X., & Mi, J. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1051866 · Cited by 62

Physical Exercise as Disease-Modifying Alternative against Alzheimer’s Disease: A Gut–Muscle–Brain Partnership

Cutuli, D., Decandia, D., Giacovazzo, G., & Coccurello, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914686 · Cited by 59

Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions

Duggal, N. A. (2018) · Biogerontology · doi:10.1007/s10522-018-9771-7 · Cited by 56

The role of myokines in cancer: crosstalk between skeletal muscle and tumor

Park, S.-Y., Hwang, B.-O., & Song, N. (2023) · BMB Reports · doi:10.5483/bmbrep.2023-0064 · Cited by 52

Regulation of Satellite Cells Functions during Skeletal Muscle Regeneration: A Critical Step in Physiological and Pathological Conditions

Careccia, G., Mangiavini, L., & Cirillo, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010512 · Cited by 63

The role of resistance exercise training for improving cardiorespiratory fitness in healthy older adults: a systematic review and meta-analysis

Smart, T., Doleman, B., Hatt, J., Paul, M., Toft, S., Lund, J. N., & Phillips, B. E. (2022) · Age and Ageing · doi:10.1093/ageing/afac143 · Cited by 51

Gut microbiota and regulation of myokine-adipokine function

Suriano, F., Hul, M. V., & Cani, P. D. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.03.006 · Cited by 49

Effect of 12-weeks elastic band resistance training on MyomiRs and osteoporosis markers in elderly women with osteosarcopenic obesity: a randomized controlled trial

Banitalebi, E., Ghahfarrokhi, M. M., & Dehghan, M. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02374-9 · Cited by 45

Exercise Training and Circulating Small Extracellular Vesicles: Appraisal of Methodological Approaches and Current Knowledge

Darragh, I. A. J., O’Driscoll, L., & Egan, B. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.738333 · Cited by 48

Molecular Mechanisms Underlying Intensive Care Unit-Acquired Weakness and Sarcopenia

Káňová, M., & Kohout, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158396 · Cited by 51

Advances in body composition and gender differences in susceptibility to frailty syndrome: Role of osteosarcopenic obesity

Conforto, R., Rizzo, V., Russo, R., Mazza, E., Maurotti, S., Pujia, C., Succurro, E., Arturi, F., Ferro, Y., Sciacqua, A., et al. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156052 · Cited by 46

Neuronal nitric oxide synthase (nNOS) splice variant function: Insights into nitric oxide signaling from skeletal muscle

Balke, J. E., Zhang, L., & Percival, J. M. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.11.004 · Cited by 44

Time Course and Role of Exercise-Induced Cytokines in Muscle Damage and Repair After a Marathon Race

Zocoler, C. A. S., Sierra, A., Galán, B. S. M., Maciel, J. F. D. S., Manoel, R., Barbeiro, H. V., de Souza, H. P., & Cury‐Boaventura, M. F. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.752144 · Cited by 51

Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: a matched transcriptomics approach after 8-week training-intervention

Dreher, S. I., Irmler, M., Pivovarova‐Ramich, O., Kessler, K., Jürchott, K., Sticht, C., Fritsche, L., Schneeweiß, P., Machann, J., Pfeiffer, A. F. H., et al. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01271-y · Cited by 43

The role of exercise in obesity-related cancers: Current evidence and biological mechanisms

Larson, E. A., Dalamaga, Μ., & Magkos, F. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.02.008 · Cited by 43

Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease

Sfyri, P., & Matsakas, A. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0346-8 · Cited by 44

Neuromuscular Electrical Stimulation: A New Therapeutic Option for Chronic Diseases Based on Contraction-Induced Myokine Secretion

Sanchis‐Gomar, F., López‐López, S., Morales, C. R., Maffulli, N., Lippi, G., & Pareja-Galeano, H. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01463 · Cited by 45

Muscular G9a Regulates Muscle-Liver-Fat Axis by Musclin Under Overnutrition in Female Mice

Zhang, W., Yang, D. L., Yuan, Y., Liu, C., Chen, H., Zhang, Y., Wang, Q., Petersen, R. B., Huang, K., & Zheng, L. (2020) · Diabetes · doi:10.2337/db20-0437 · Cited by 44

The effect of differentiation and TGFβ on mitochondrial respiration and mitochondrial enzyme abundance in cultured primary human skeletal muscle cells

Hoffmann, C., Höckele, S., Kappler, L., de Angelis, M. H., Häring, H., & Weigert, C. (2018) · Scientific Reports · doi:10.1038/s41598-017-18658-3 · Cited by 43

Effects of Regular Taekwondo Intervention on Oxidative Stress Biomarkers and Myokines in Overweight and Obese Adolescents

Roh, H., Cho, S.-Y., & So, W.-Y. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072505 · Cited by 41

The intrinsic and extrinsic elements regulating inflammation

Mollaei, M., Abbasi, A., Hassan, Z. M., & Pakravan, N. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118258 · Cited by 42

Effects of Various Muscle Disuse States and Countermeasures on Muscle Molecular Signaling

Sharlo, K. A., Tyganov, S. A., Tomilovskaya, E., Popov, D. V., Saveko, A. A., & Shenkman, B. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010468 · Cited by 47

A focused review of myokines as a potential contributor to muscle hypertrophy from resistance-based exercise

Cornish, S. M., Bugera, E. M., Duhamel, T. A., Peeler, J. D., & Anderson, J. E. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04337-1 · Cited by 43

Interplay between hormones and exercise on hippocampal plasticity across the lifespan

Bettio, L. E. B., Thacker, J. S., Rodgers, S. P., Brocardo, P. S., Christie, B. R., & Gil-Mohapel, J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165821 · Cited by 40

Postnatal skeletal muscle myogenesis governed by signal transduction networks: MAPKs and PI3K–Akt control multiple steps

Endo, T. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.09.048 · Cited by 43

Effect of Cocoa Products and Its Polyphenolic Constituents on Exercise Performance and Exercise-Induced Muscle Damage and Inflammation: A Review of Clinical Trials

Massaro, M., Scoditti, E., Carluccio, M. A., Καλτσάτου, Α., & Cicchella, A. (2019) · Nutrients · doi:10.3390/nu11071471 · Cited by 42

Network Physiology of Exercise: Beyond Molecular and Omics Perspectives

Balagué, N., Hristovski, R., Almarcha, M., García‐Retortillo, S., & Ivanov, P. C. (2022) · Sports Medicine - Open · doi:10.1186/s40798-022-00512-0 · Cited by 40

Musculoskeletal health in children and adolescents

Faienza, M. F., Urbano, F., Chiarito, M., Lassandro, G., & Giordano, P. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1226524 · Cited by 48

Interleukin-15 responses to acute and chronic exercise in adults: a systematic review and meta-analysis

Khalafi, M., Maleki, A. H., Symonds, M. E., Sakhaei, M. H., Rosenkranz, S. K., Ehsanifar, M., Korivi, M., & Liu, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1288537 · Cited by 37

Skeletal Muscle Nrf2 Contributes to Exercise-Evoked Systemic Antioxidant Defense Via Extracellular Vesicular Communication

Gao, L., Wang, H., Tian, C., & Zucker, I. H. (2021) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000257 · Cited by 39

Reactive Oxygen and Nitrogen Species (RONS) and Cytokines—Myokines Involved in Glucose Uptake and Insulin Resistance in Skeletal Muscle

Llanos, P., & Palomero, J. (2022) · Cells · doi:10.3390/cells11244008 · Cited by 39

Expression Pattern of Angiogenic Factors in Healthy Heart in Response to Physical Exercise Intensity

Bellafiore, M., Battaglia, G., Bianco, A., & Palma, A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00238 · Cited by 36

Magnetic fields modulate metabolism and gut microbiome in correlation with Pgc‐1α expression: Follow‐up to an in vitro magnetic mitohormetic study

Tai, Y. K., Ng, C., Purnamawati, K., Yap, J. L. Y., Yin, J. N., Wong, C. J. K., Patel, B. K., Soong, P. L., Pelczar, P., Fröhlich, J., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201903005rr · Cited by 36

Hypoxanthine Induces Muscular ATP Depletion and Fatigue via UCP2

Yin, C., Ma, Z., Li, F., Duan, C., Yuan, Y., Zhu, C., Wang, L., Zhu, X., Wang, S., Gao, P., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.647743 · Cited by 36

Physical Exercise Restrains Cancer Progression through Muscle-Derived Factors

Papadopetraki, Α., Maridaki, M. D., Zagouri, F., Dimopoulos, M. A., Koutsilieris, M., & Philippou, Α. (2022) · Cancers · doi:10.3390/cancers14081892 · Cited by 36

Impact of acute exercise on immediate and following early post-exercise FGF-21 concentration in adults: Systematic review and meta-analysis

Khalafi, M., Alamdari, K. A., Symonds, M. E., Nobari, H., & Carlos-Vivas, J. (2021) · HORMONES · doi:10.1007/s42000-020-00245-3 · Cited by 34

Conditioned media from AICAR-treated skeletal muscle cells increases neuronal differentiation of adult neural progenitor cells

Moon, H. Y., Javadi, S., Stremlau, M. H., Yoon, K. J., Becker, B., Kang, S.-U., Zhao, X., & van Praag, H. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.10.041 · Cited by 36

Suppressive effects of exercise-conditioned serum on cancer cells: A narrative review of the influence of exercise mode, volume, and intensity

Bettariga, F., Taaffe, D. R., Galvao, D. A., Bishop, C. J., Kim, J., & Newton, R. U. (2023) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2023.12.001 · Cited by 35

Exercise as a tool to mitigate metabolic disease

Esteves, J. V. D. C., & Stanford, K. I. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00144.2024 · Cited by 39

Genome-Wide Chromatin Structure Changes During Adipogenesis and Myogenesis

He, M., Li, Y., Tang, Q., Li, D., Jin, L. G., Tian, S., Che, T., Shen, H., Deng, L., Gao, G., et al. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.25328 · Cited by 33

Physical activity and advanced cancer: evidence of exercise‐sensitive genes regulating prostate cancer cell proliferation and apoptosis

Schwappacher, R., Schink, K., Sologub, S., Dieterich, W., Reljic, D., Friedrich, O., Herrmann, H. J., Neurath, M. F., & Zopf, Y. (2020) · The Journal of Physiology · doi:10.1113/jp279150 · Cited by 38

Role of Regular Physical Exercise in Tumor Vasculature: Favorable Modulator of Tumor Milieu

Esteves, M., Monteiro, M. P., & Duarte, J. A. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1308-3476 · Cited by 35

Association Between the Serum Creatinine to Cystatin C Ratio and Cardiovascular Disease in Middle‐Aged and Older Adults in China: A Nationwide Cohort Study

Chen, J., Yan, L., Hu, L., Xiao, S., Liao, Y., Yao, X., & Yang, R. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.040050 · Cited by 33

Resistance training rejuvenates aging skin by reducing circulating inflammatory factors and enhancing dermal extracellular matrices

Nishikori, S., Yasuda, J., Murata, K., Takegaki, J., Harada, Y., Shirai, Y., & Fujita, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-37207-9 · Cited by 31

Non-coding RNAs and exercise: pathophysiological role and clinical application in the cardiovascular system

Gomes, C. P. C., de Gonzalo‐Calvo, D., Toro, R., Fernandes, T. M., Theisen, D., Wang, D., Devaux, Y., & on behalf of the Cardiolinc™ network (2018) · Clinical Science · doi:10.1042/cs20171463 · Cited by 31

Inter-organ communication during tissue regeneration

Sun, F., & Poss, K. D. (2023) · Development · doi:10.1242/dev.202166 · Cited by 30

Sarcopenia as a Prognostic Factor in Peripheral Arterial Disease: Descriptive Review

Ferreira, J. M. M., Cunha, P., Carneiro, A. L., Vila, I., Cunha, C., Silva, C., Longatto‐Filho, A., Mesquita, A. V. S. C., Cotter, J., Mansilha, A., et al. (2021) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2021.01.076 · Cited by 28

Precision Exercise Medicine: Sex Specific Differences in Immune and CNS Responses to Physical Activity

Cortés, C. J., & Miguel, Z. D. (2022) · Brain Plasticity · doi:10.3233/bpl-220139 · Cited by 34

Signals from the Circle: Tricarboxylic Acid Cycle Intermediates as Myometabokines

Maurer, J., Hoene, M., & Weigert, C. (2021) · Metabolites · doi:10.3390/metabo11080474 · Cited by 27

Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation

Xiong, X., Zuo, Y., Cheng, L., Yin, Z., Hu, T., Guo, M., Han, Z., Ge, X., Li, W., Wang, Y., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.816752 · Cited by 27

Effects of Aerobic and Resistance Exercise on Myokines in High Fat Diet-Induced Middle-Aged Obese Rats

Ahn, N., & Kim, K. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17082685 · Cited by 29

Sarcopenic obesity in cancer

Jurdana, M., & Čemažar, M. (2024) · Radiology and Oncology · doi:10.2478/raon-2024-0011 · Cited by 27

AMP‐activated protein kinase activation in skeletal muscle modulates exercise‐induced uncoupled protein 1 expression in brown adipocyte in mouse model

Kim, H. J., Kim, Y. J., & Seong, J. K. (2022) · The Journal of Physiology · doi:10.1113/jp282999 · Cited by 31

Resistance Exercise Improves Glycolipid Metabolism and Mitochondrial Biogenesis in Skeletal Muscle of T2DM Mice via miR-30d-5p/SIRT1/PGC-1α Axis

Zheng, L., Rao, Z., Wu, J., Ma, X., Jiang, Z., & Xiao, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212416 · Cited by 25

Skeletal muscle as a pro- and anti-inflammatory tissue: insights from children to adults and ultrasound findings

Ludovico, A. D., Bella, S. L., Ciarelli, F., Chiarelli, F., Breda, L., & Mohn, A. (2024) · Journal of Ultrasound · doi:10.1007/s40477-024-00917-5 · Cited by 27

Regulation of Acetylcholine Quantal Release by Coupled Thrombin/BDNF Signaling in Mouse Motor Synapses

Gaydukov, A. E., Bogacheva, P. O., Tarasova, E., Molchanova, А. I., Miteva, A. S., Pravdivceva, E., & Balezina, O. P. (2019) · Cells · doi:10.3390/cells8070762 · Cited by 27

Irisin Improves High-Fat Diet-Induced Sexual Dysfunction in Obese Male Rats

Yardımcı, A., Ülker, N., Bulmuş, Ö., Şahin, E., Alver, A., Güngör, İ. H., Türk, G., Artaş, G., Tektemur, N. K., Özcan, M., et al. (2022) · Neuroendocrinology · doi:10.1159/000523689 · Cited by 25

CRISPRa‐based activation of Fgf21 and Fndc5 ameliorates obesity by promoting adipocytes browning

Zhu, H., Liu, D., Sui, M., Zhou, M., Wang, B., Qi, Q., Wang, T., Zhang, G., Wan, F., & Zhang, B. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1326 · Cited by 27

New role of fat-free mass in cancer risk linked with genetic predisposition

Harris, B. H. L., Di Giovannantonio, M., Zhang, P., Harris, D. A., Lord, S. R., Allen, N. E., Maughan, T. S., Bryant, R. J., Harris, A. L., Bond, G. L., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-54291-7 · Cited by 24

Exercise and the organ-brain axis: Regulation of neurological disorders by emerging exerkines

Dai, Y., Dou, X., Nie, B., Sun, Y., Chen, P., Fu, C., Zhang, X., Chu, Y., Gao, Q., Ge, Y., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107913 · Cited by 27

LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p

Zhang, P., Du, J., Guo, X., Wu, S., He, J., Li, X., Shen, L., Chen, L., Li, B., Zhang, J., et al. (2021) · Genes · doi:10.3390/genes12040589 · Cited by 24

Muscle Regeneration and Function in Sports: A Focus on Vitamin D

Iolascon, G., Moretti, A., Paoletta, M., Liguori, S., & Munno, O. D. (2021) · Medicina · doi:10.3390/medicina57101015 · Cited by 24

Association between physical activity and cognition in Mexican and Korean older adults

Aarsland, V., Borda, M. G., Aarsland, D., Garcia-Cifuentes, E. R., Anderssen, S. A., Tovar, D., Arteaga, R. C. G., & Pérez‐Zepeda, M. U. (2020) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2020.104047 · Cited by 24

Skeletal Muscle: A Significant Novel Neurohypophyseal Hormone-Secreting Organ

Adamo, S., Pigna, E., Lugarà, R., Moresi, V., Coletti, D., & Bouché, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01885 · Cited by 23

Edward F. Adolph Distinguished Lecture: Muscle as an endocrine organ: IL-6 and other myokines

Pedersen, B. K. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00734.2009 · Cited by 221

Myokines are one of the key elements of interaction between skeletal muscles and other systems of human body necessary for adaptation to physical loads

Tymochko-Voloshyn, R. I., Hashchyshyn, V., Параняк, Н., Boretsky, V. Y., Решетило, С., & Boretsky, Y. (2023) · Visnyk of Lviv University Biological series · doi:10.30970/vlubs.2023.88.01 · Cited by 4

Skeletal Muscle, Myokines and Health

Düzova, H. (2012) · Medicine Science | International Medical Journal · doi:10.5455/medscience.2012.01.8023 · Cited by 14

Muscle–Organ Crosstalk: The Emerging Roles of Myokines

Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226

[Secretory Function of Skeletal Muscles: Producing Mechanisms and Myokines Physiological Effects].

Капилевич, Л. В., Kabachkova, A. V., An, Z., Сергеевна, Л. Г., Кироненко, Т. А., Ey, D., & Orlov, S. N. (2016) · PubMed · Cited by 9