The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
siRNAs can function as miRNAs
Open accessAbstract
With the discovery of RNA interference (RNAi) and related phenomena, new regulatory roles attributed to RNA continue to emerge. Here we show, in mammalian tissue culture, that a short interfering RNA (siRNA) can repress expression of a target mRNA with partially complementary binding sites in its 3′ UTR, much like the demonstrated function of endogenously encoded microRNAs (miRNAs). The mechanism for this repression is cooperative, distinct from the catalytic mechanism of mRNA cleavage by siRNAs. The use of siRNAs to study translational repression holds promise for dissecting the sequence and structural determinants and general mechanism of gene repression by miRNAs.
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
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miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
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Cited by
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
The functions of animal microRNAs
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MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 7,118
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
Metadata
- Authors
- Doench, J. G., Petersen, C. P., & Sharp, P. A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-02-15
- Volume
- 17
- Issue
- 4
- Pages
- 438-442
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2139871850
- Cited by
- 1,260
- References
- 7
- Type
- posted content
- Language
- en
- Open access
- diamond
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