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Ribosomal Protein S6 Kinase Is a Critical Downstream Effector of the Target of Rapamycin Complex 1 for Long-term Facilitation in Aplysia

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Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bɛ mRNA translation and protein synthesis

Kubica, N., Crispino, J. L., Gallagher, J. W., Kimball, S. R., & Jefferson, L. S. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.04.010 · Cited by 32

The promise of mTOR inhibitors in the treatment of colorectal cancer

Kim, D.-D., & Eng, C. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2012.721353 · Cited by 31

Quantification of the effect of amino acids on an integrated mTOR and insulinsignaling pathway

Vinod, P. K. U., & Venkatesh, K. V. (2009) · Molecular BioSystems · doi:10.1039/b816965a · Cited by 30

Differential IKK/NF-κB Activity Is Mediated by TSC2 through mTORC1 in PTEN-Null Prostate Cancer and Tuberous Sclerosis Complex Tumor Cells

Gao, Y., Gartenhaus, R. B., Lapidus, R. G., Hussain, A., Zhang, Y., Wang, X., & Dan, H. C. (2015) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-15-0213 · Cited by 31

TSC2/Rheb signaling mediates ERK‐dependent regulation of mTORC1 activity in C2C12 myoblasts

Miyazaki, M., & Takemasa, T. (2017) · FEBS Open Bio · doi:10.1002/2211-5463.12195 · Cited by 34

Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis

Zech, R., Kiontke, S., Mueller, U., Oeckinghaus, A., & Kümmel, D. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.732446 · Cited by 29

Epigenetic regulation of autophagy in neuroinflammation and synaptic plasticity

Bai, I., Keyser, C., Zhang, Z., Rosolia, B. J., Hwang, J.-Y., Zukin, R. S., & Yan, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1322842 · Cited by 32

Using Neurofibromatosis-1 to Better Understand and Treat Pediatric Low-Grade Glioma

Gutmann, D. H. (2008) · Journal of Child Neurology · doi:10.1177/0883073808321061 · Cited by 29

PRL-3 activates mTORC1 in Cancer Progression

Ye, Z., Al-Aidaroos, A. Q., Park, J. E., Yuen, H. F., Zhang, S., Gupta, A. K., Lin, Y., Shen, H., & Zeng, Q. (2015) · Scientific Reports · doi:10.1038/srep17046 · Cited by 29

Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer

Lee, M. J., Jin, N., Grandis, J. R., & Johnson, D. E. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118679 · Cited by 29

The market for amino acids: understanding supply and demand of substrate for more efficient milk protein synthesis

Pszczolkowski, V. L., & Apelo, S. I. A. (2020) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-020-00514-6 · Cited by 33

mTOR Signaling as a Target of Amino Acid Treatment of the Age-Related Sarcopenia

D’Antona, G., & Nisoli, E. (2010) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000319998 · Cited by 29

Uterine Histotroph and Conceptus Development. I. Cooperative Effects of Arginine and Secreted Phosphoprotein 1 on Proliferation of Ovine Trophectoderm Cells via Activation of the PDK1-Akt/PKB-TSC2-MTORC1 Signaling Cascade1

Wang, X., Johnson, G. A., Burghardt, R. C., Wu, G., & Bazer, F. W. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.125971 · Cited by 29

TSC2: filling the GAP in the mTOR signaling pathway

Li, Y. (2003) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2003.11.007 · Cited by 418

Biochemical and Functional Characterizations of Small GTPase Rheb and TSC2 GAP Activity

Li, Y., Inoki, K., & Guan, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.7965-7975.2004 · Cited by 240

Regulation of TS1/TSC2 Stability and Rheb GTP Level by Herc1

Guan, K. (2006) · doi:10.21236/ada470087

Measurements of TSC2 GAP Activity Toward Rheb

Li, Y., Inoki, K., Vikis, H. G., & Guan, K. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)07005-9 · Cited by 19

Defining the biochemical functions of the TSC complex and its regulation of Rheb-mTORC1 signaling

Lockwood, S. (2023) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)