Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083

eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

Gingras, A., Raught, B., & Sonenberg, N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.913 · Cited by 2,103

Identification and characterization of the tuberous sclerosis gene on chromosome 16

(1993) · Cell · doi:10.1016/0092-8674(93)90618-z · Cited by 1,645

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., & Cantley, L. C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00568-3 · Cited by 1,555

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

Hara, K., Yonezawa, K., Weng, Q.-P., Kozlowski, M. T., BELHAM, C. M., & Avruch, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14484 · Cited by 1,370

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

Trahey, M., & McCormick, F. (1987) · Science · doi:10.1126/science.2821624 · Cited by 1,211

FUNCTION AND REGULATION OF RAS

Lowy, D. R., & Willumsen, B. M. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.004223 · Cited by 1,164

Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., & Chen, J. (2001) · Science · doi:10.1126/science.1066015 · Cited by 1,055

Mammalian TOR: a homeostatic ATP sensor

Dennis, P. B., Jaeschke, A., Saitoh, M., Fowler, B., Kozma, S. C., & Thomas, G. (2001) · Science · doi:10.1126/science.1063518 · Cited by 962

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

Tee, A. R., Fingar, D. C., Manning, B. D., Kwiatkowski, D. J., Cantley, L. C., & Blenis, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202476899 · Cited by 827

Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die

Hwang, J.-Y., Gertner, M. J., Pontarelli, F., Court-Vazquez, B. L., Bennett, M. V. L., Ofengeim, D., & Zukin, R. S. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.140 · Cited by 113

Molecular Mechanisms of Muscle Plasticity with Exercise

Hoppeler, H. H., Baum, O., Lurman, G. J., & Mueller, M. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100042 · Cited by 131

Molecular Pathways Underlying Projection Neuron Production and Migration during Cerebral Cortical Development

Ohtaka‐Maruyama, C., & Okado, H. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00447 · Cited by 113

Pompe Disease: New Developments in an Old Lysosomal Storage Disorder

Meena, N. K., & Raben, N. (2020) · Biomolecules · doi:10.3390/biom10091339 · Cited by 117

Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging

Wang, Q., Nie, L., Zhao, P., Zhou, X., Ding, Y., Chen, Q., & Wang, Q. (2021) · International Journal of Oral Science · doi:10.1038/s41368-021-00116-6 · Cited by 113

Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast

Hallett, J. E. H., Luo, X., & Capaldi, A. P. (2015) · eLife · doi:10.7554/elife.09181 · Cited by 112

Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism

Liao, X., Majithia, A. R., Huang, X., & Kimmel, A. R. (2008) · Amino Acids · doi:10.1007/s00726-008-0100-3 · Cited by 112

Insulin Signaling in the Control of Glucose and Lipid Homeostasis

Saltiel, A. R. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_14 · Cited by 116

Structural insights into TSC complex assembly and GAP activity on Rheb

Yang, H., Yu, Z., Chen, X., Li, J., Li, N., Cheng, J., Gao, N., Yuan, H., Ye, D., Guan, K., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20522-4 · Cited by 114

Interaction between the AMP-Activated Protein Kinase and mTOR Signaling Pathways

Kimball, S. R. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000233796.16411.13 · Cited by 110

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

Jewell, J. L., Fu, V. X., Hong, A. W., Yu, F., Meng, D., Melick, C. H., Wang, H., Lam, W.-L. M., Yuan, H.-X., Taylor, S. S., et al. (2019) · eLife · doi:10.7554/elife.43038 · Cited by 115

Ras moves to stay in place

Schmick, M., Kraemer, A., & Bastiaens, P. I. H. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.02.004 · Cited by 110

MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

Hsu, C. L., Lee, E. X., Gordon, K. L., Paz, E. A., Shen, W.-C., Ohnishi, K., Meisenhelder, J., Hunter, T. R., & Spada, A. R. L. (2018) · Nature Communications · doi:10.1038/s41467-018-03340-7 · Cited by 110

Neuronal lysosomes

Ferguson, S. M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.04.005 · Cited by 107

Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation

Raslová, H., Baccini, V., Loussaief, L., Comba, B., Larghero, J., Debili, N., & Vainchenker, W. (2005) · Blood · doi:10.1182/blood-2005-07-3005 · Cited by 114

Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin

Han, J., Wang, B., Xiao, Z., Gao, Y., Zhao, Y., Zhang, J., Chen, B., Wang, X., & Dai, J. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.06.003 · Cited by 107

mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat

Chotechuang, N., Azzout‐Marniche, D., Bos, C., Chaumontet, C., Gausserès, N., Steiler, T. L., Gaudichon, C., & Tomé, D. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.91000.2008 · Cited by 113

Mechanisms of amino acid sensing in mTOR signaling pathway

Kim, E. (2009) · Nutrition Research and Practice · doi:10.4162/nrp.2009.3.1.64 · Cited by 104

The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb

Kelleher, A. R., Kimball, S. R., Dennis, M. D., Schilder, R. J., & Jefferson, L. S. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00409.2012 · Cited by 111

TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism

Alesi, N., Akl, E. W., Khabibullin, D., Liu, H.-J., Nidhiry, A. S., Garner, E. R., Filippakis, H., Lam, H. C., Shi, W., Viswanathan, S. R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24499-6 · Cited by 106

Rapid Turnover of the mTOR Complex 1 (mTORC1) Repressor REDD1 and Activation of mTORC1 Signaling following Inhibition of Protein Synthesis

Kimball, S. R., Do, A. N. D., Kutzler, L., Cavener, D. R., & Jefferson, L. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706643200 · Cited by 106

mTOR at the crossroads of T cell proliferation and tolerance

Mondino, A., & Mueller, D. L. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.02.008 · Cited by 107

Tsc1+ and tsc2+ Regulate Arginine Uptake and Metabolism in Schizosaccharomyces pombe

van Slegtenhorst, M., Carr, E. L., Stoyanova, R. S., Kruger, W. D., & Henske, E. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313874200 · Cited by 106

Normal hypertrophy accompanied by phosphoryation and activation of AMP‐activated protein kinase α1 following overload in LKB1 knockout mice

McGee, S. L., Mustard, K. J., Hardie, D. G., & Baar, K. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.143685 · Cited by 105

Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies

Chapuis, N., Tamburini, J., Green, A. S., Willems, L., Bardet, V., Park, S., Lacombe, C., Mayeux, P., & Bouscary, D. (2010) · Leukemia · doi:10.1038/leu.2010.170 · Cited by 109

C. elegans AMPKs promote survival and arrest germline development during nutrient stress

Fukuyama, M., Sakuma, K., Park, R., Hidefumi, K., Nagaya, R., Atsumi, Y., Shimomura, Y., Takahashi, S., Kajiho, H., Rougvie, A. E., et al. (2012) · Biology Open · doi:10.1242/bio.2012836 · Cited by 105

Tsc2 is not a critical target of Akt during normal Drosophila developmentPreprint

Dong, J., & Pan, D. (2004) · Genes & Development · doi:10.1101/gad.1240504 · Cited by 104

The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells

White, J. P., Billin, A. N., Campbell, M. E., Russell, A. J., Huffman, K. M., & Kraus, W. E. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.014 · Cited by 104

Cellular and molecular effects of the mTOR inhibitor everolimus

Saran, U., Foti, M., & Dufour, J. (2015) · Clinical Science · doi:10.1042/cs20150149 · Cited by 111

Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway

Tang, H., Li, J., Liu, X., Wang, G., Luo, M., & Deng, H. (2016) · Scientific Reports · doi:10.1038/srep28388 · Cited by 106

Oncosuppressive Functions of Autophagy

Morselli, E., Galluzzi, L., Kepp, O., Mariño, G., Michaud, M., Vitale, I., Maiuri, M. C., & Kroemer, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3478 · Cited by 112

Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases

Huynh, C. Q., Ryu, J., Lee, J., Inoki, A., & Inoki, K. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00648-y · Cited by 109

New developments in AMPK and mTORC1 cross-talk

Smiles, W. J., Ovens, A. J., Kemp, B. E., Galić, S., Petersen, J., & Oakhill, J. S. (2024) · Essays in Biochemistry · doi:10.1042/ebc20240007 · Cited by 124

Critical roles for the TSC-mTOR pathway in β-cell function

Mori, H., Inoki, K., Opland, D. M., Münzberg, H., Villanueva, E. C., Faouzi, M., Ikenoue, T., Kwiatkowski, D. J., MacDougald, O. A., Myers, M. G., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00262.2009 · Cited by 104

Regulating Autophagy as a Therapeutic Target for Diabetic Nephropathy

Kitada, M., Ogura, Y., Monno, I., & Koya, D. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0879-y · Cited by 102

Pulmonary Cysts of Birt-Hogg-Dubé Syndrome

Furuya, M., Tanaka, R., Koga, S., Yatabe, Y., Gotoda, H., Takagi, S. T., Hsu, Y.-H., Fujii, T., Okada, A., Kuroda, N., et al. (2012) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e3182475240 · Cited by 102

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

Shen, K., Choe, A., & Sabatini, D. M. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.09.026 · Cited by 101

Autophagy in neuronal cells: general principles and physiological and pathological functions

Daμμe, M., Suntio, T., Säftig, P., & Eskelinen, E. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1361-4 · Cited by 109

Efficacy and Safety of Topical Sirolimus Therapy for Facial Angiofibromas in the Tuberous Sclerosis Complex

Wataya‐Kaneda, M., Nakamura, A., Tanaka, M., Hayashi, M., Matsumoto, S., Yamamoto, K., & Katayama, I. (2016) · JAMA Dermatology · doi:10.1001/jamadermatol.2016.3545 · Cited by 105

Formation of the retinotectal projection requires Esrom, an ortholog of PAM (protein associated with Myc)

D'Souza, J., Hendricks, M., Guyader, S. L., Subburaju, S., Grunewald, B., Scholich, K., & Jesuthasan, S. J. (2004) · Development · doi:10.1242/dev.01578 · Cited by 101

A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

Chen, X.-W., Leto, D., Xiong, T., Yu, G., Cheng, A., Decker, S., & Saltiel, A. R. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-08-0665 · Cited by 108

Role of AMP‐Activated Protein Kinase in Cancer Therapy

Rehman, G., Shehzad, A., Khan, A. L., & Hamayun, M. (2014) · Archiv der Pharmazie · doi:10.1002/ardp.201300402 · Cited by 107

Serotonin-Induced Growth of Pulmonary Artery Smooth Muscle Requires Activation of Phosphatidylinositol 3-Kinase/Serine-Threonine Protein Kinase B/Mammalian Target of Rapamycin/p70 Ribosomal S6 Kinase 1

Liu, Y., & Fanburg, B. L. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0163oc · Cited by 98

Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin

Kimball, S. R., & Jefferson, L. S. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200401000-00008 · Cited by 99

Molecular Pathogenesis of Lymphangioleiomyomatosis

Juvet, S., McCormack, F. X., Kwiatkowski, D. J., & Downey, G. P. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0372tr · Cited by 100

Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner

Banerjee, S., Crouse, N. R., Emnett, R. J., Gianino, S. M., & Gutmann, D. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019012108 · Cited by 99

Regulation of B-Raf Kinase Activity by Tuberin and Rheb Is Mammalian Target of Rapamycin (mTOR)-independent

Karbowniczek, M., Cash, T. P., Cheung, M., Robertson, G. P., Astrinidis, A., & Henske, E. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402591200 · Cited by 99

Transcriptional regulation of the stress response by mTOR

Aramburu, J. F., Ortells, M. C., Vaquero, S. T., Buxadé, M., & López‐Rodríguez, C. (2014) · Science Signaling · doi:10.1126/scisignal.2005326 · Cited by 100

Lymphangioleiomyomatosis: what do we know and what are we looking for?

Harari, S. A., Torre, O., & Moss, J. (2011) · European Respiratory Review · doi:10.1183/09059180.00011010 · Cited by 98

The Role of Retinoic Acid (RA) in Spermatogonial Differentiation1

Busada, J. T., & Geyer, C. B. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.135145 · Cited by 98

Regulation of mTORC1 by Upstream Stimuli

Melick, C. H., & Jewell, J. L. (2020) · Genes · doi:10.3390/genes11090989 · Cited by 104

Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways

Ramírez-Reyes, J. M. J., Cuesta, R., & Pause, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.667311 · Cited by 98

Structural analysis of the Ras‐like G protein MglA and its cognate GAP MglB and implications for bacterial polarity

Miertzschke, M., Koerner, C., Vetter, I. R., Keilberg, D., Hot, E., Leonardy, S., Søgaard‐Andersen, L., & Wittinghofer, A. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.291 · Cited by 98

Inhibition of Fatty-acid Synthase Induces Caspase-8-mediated Tumor Cell Apoptosis by Up-regulating DDIT4

Knowles, L. M., Chen, Y., Osterman, A. L., & Smith, J. W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803384200 · Cited by 100

Autophagy-regulating small molecules and their therapeutic applications

Baek, K.-H., Park, J., & Shin, I. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15328a · Cited by 101

Molecular mechanisms of mTOR regulation by stress

Heberle, A. M., Prentzell, M. T., van Eunen, K., Bakker, B. M., Grellscheid, S. N., & Thedieck, K. (2014) · Molecular & Cellular Oncology · doi:10.4161/23723548.2014.970489 · Cited by 102

Autophagy and proteins involved in vesicular trafficking

Sanchez, C. A., Fader, C. M., & Colombo, M. I. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.09.021 · Cited by 106

Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin

Xu, J., Pham, C. G., Albanese, S. K., Dong, Y., Oyama, T., Lee, C., Rodrik-Outmezguine, V. S., Yao, Z., Han, S. I., Chen, D., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86120 · Cited by 100

4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1

Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M.-Q., Wong, C. C. L., Wang, J., Xu, Y., et al. (2016) · Protein & Cell · doi:10.1007/s13238-016-0346-6 · Cited by 96

Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply

Zhang, H., Yan, S., Khambu, B., Ma, F., Li, Y., Chen, X., Martina, J. A., Puertollano, R., Li, Y., Chalasani, N., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1490850 · Cited by 96

Time course changes in signaling pathways and protein synthesis in C2C12myotubes following AMPK activation by AICAR

Williamson, D. L., Bolster, D. R., Kimball, S. R., & Jefferson, L. S. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00566.2005 · Cited by 100

The CRB1 and adherens junction complex proteins in retinal development and maintenance

Alves, C. H., Pellissier, L. P., & Wijnholds, J. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.01.001 · Cited by 96

Differential Membrane Localization of ERas and Rheb, Two Ras-related Proteins Involved in the Phosphatidylinositol 3-Kinase/mTOR Pathway

Takahashi, K., Nakagawa, M., Young, S. G., & Yamanaka, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506280200 · Cited by 97

Rag GTPases are cardioprotective by regulating lysosomal function

Kim, Y. C., Park, H. W., Sciarretta, S., Mo, J., Jewell, J. L., Russell, R. C., Wu, X., Sadoshima, J., & Guan, K. (2014) · Nature Communications · doi:10.1038/ncomms5241 · Cited by 94

Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution

Li, M., Yu, J., Tilgner, K., Ong, S. H., Koike-Yusa, H., & Yusa, K. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.027 · Cited by 96

Nutrient Signaling Components Controlling Protein Synthesis in Striated Muscle ,

Vary, T. C., & Lynch, C. J. (2007) · Journal of Nutrition · doi:10.1093/jn/137.8.1835 · Cited by 96

The Tuberous Sclerosis Complex Genes in Tumor Development

Mak, B. C., & Yeung, R. S. W. (2004) · Cancer Investigation · doi:10.1081/cnv-200027144 · Cited by 94

Exercise‐induced alterations in extracellular signal‐regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle

Williamson, D. L., Kubica, N., Kimball, S. R., & Jefferson, L. S. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.103481 · Cited by 96

Metabolic alterations in renal cell carcinoma

Massari, F., Ciccarese, C., Santoni, M., Brunelli, M., Piva, F., Modena, A., Bimbatti, D., Fantinel, E., Santini, D., Liang Cheng, C., et al. (2015) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2015.07.002 · Cited by 99

Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent mannerPreprint

Kaul, A., Chen, Y., Emnett, R. J., Dahiya, S. M., & Gutmann, D. H. (2012) · Genes & Development · doi:10.1101/gad.200907.112 · Cited by 97

Regulation of rDNA transcription in response to growth factors, nutrients and energy

Kusnadi, E. P., Hannan, K. M., Hicks, R. J., Hannan, R. D., Pearson, R. B., & Kang, J. (2014) · Gene · doi:10.1016/j.gene.2014.11.010 · Cited by 105

Iron overload inhibits late stage autophagic flux leading to insulin resistance

Jahng, J. W. S., Alsaadi, R. M., Palanivel, R., Song, E., Hipolito, V. E. B., Sung, H. K., Botelho, R. J., Russell, R. C., & Sweeney, G. (2019) · EMBO Reports · doi:10.15252/embr.201947911 · Cited by 97

Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis

Carroll, B., Korolchuk, V. I., & Sarkar, S. (2014) · Amino Acids · doi:10.1007/s00726-014-1775-2 · Cited by 99

AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells

Agarwal, S., Bell, C. M., Rothbart, S. B., & Moran, R. G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.665133 · Cited by 97

Inhibitors of the mammalian target of rapamycin

Dancey, J. E. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.3.313 · Cited by 95

Deconvoluting mTOR biology

Weber, J. D., & Gutmann, D. H. (2012) · Cell Cycle · doi:10.4161/cc.11.2.19022 · Cited by 97

Therapeutic targeting of mTOR in tuberous sclerosis

Sampson, J. R. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370259 · Cited by 94

Targeting the genetic alterations of the PI3K–AKT–mTOR pathway: Its potential use in the treatment of bladder cancers

Houédé, N., & Pourquier, P. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.06.004 · Cited by 94

Modulation of mTOR signaling as a strategy for the treatment of Pompe disease

Lim, J., Li, L., Shirihai, O. S., Trudeau, K. M., Puertollano, R., & Raben, N. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201606547 · Cited by 97

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control

Gan, W., Dai, X., Dai, X., Xie, J., Yin, S., Zhu, J., Wang, C., Liu, Y., Guo, J., Wang, M., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0463-6 · Cited by 97

Coupling of Mammalian Target of Rapamycin with Phosphoinositide 3-Kinase Signaling Pathway Regulates Protein Phosphatase 2A- and Glycogen Synthase Kinase-3β-dependent Phosphorylation of Tau

Meske, V., Albert, F., & Ohm, T. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704292200 · Cited by 95

The therapeutic potential of insulin-like growth factor-1 in central nervous system disorders

Costales, J. L., & Kolevzon, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.01.001 · Cited by 98

Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast

Urano, J., Comiso, M. J., Guo, L., Aspuria, P.-J. P., Deniskin, R., Tabancay, A. P., Kato‐Stankiewicz, J., & Tamanoi, F. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04877.x · Cited by 94

Tuberous Sclerosis Complex–Associated Angiomyolipomas: Focus on mTOR Inhibition

Budde, K., & Gaedeke, J. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2011.10.013 · Cited by 93

Nitrogen Regulates AMPK to Control TORC1 Signaling

Davie, E., Forte, G., & Petersen, J. (2015) · Current Biology · doi:10.1016/j.cub.2014.12.034 · Cited by 97

Frontier of Epilepsy Research - mTOR signaling pathway

Cho, C. (2011) · Experimental & Molecular Medicine · doi:10.3858/emm.2011.43.5.032 · Cited by 93

A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits

Feliciano, D. M., Lin, T. V., Hartman, N. W., Bartley, C. M., Kubera, C., Hsieh, L. S., Lafourcade, C., O’Keefe, R. A., & Bordey, A. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.02.008 · Cited by 95

Beyond controlling cell size: functional analyses of S6K in tumorigenesis

Wu, X., Xie, W., Xie, W., Wei, W., & Guo, J. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05081-4 · Cited by 96

Recent advances in the regulation of the TOR pathway by insulin and nutrients

Avruch, J., Lin, Y., Long, X., Murthy, S., & Ortiz-Vega, S. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200501000-00010 · Cited by 91

Multifaceted roles of Adiponectin in cancer

Hebbard, L., & Ranscht, B. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.11.005 · Cited by 94

Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi–lysosome contact site

Hao, F., Kondo, K., Itoh, T., Ikari, S., Nada, S., Okada, M., & Noda, T. (2018) · Journal of Cell Science · doi:10.1242/jcs.208017 · Cited by 91

An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

Nüchel, J., Tauber, M., Nolte, J. L., Mörgelin, M., Türk, C., Eckes, B., Demetriades, C., & Plomann, M. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.06.017 · Cited by 90

An activated mTOR mutant supports growth factor-independent, nutrient-dependent cell survival

Edinger, A. L., & Thompson, C. B. (2004) · Oncogene · doi:10.1038/sj.onc.1207738 · Cited by 91

Inhibition of Protein Synthesis by Y Box-Binding Protein 1 Blocks Oncogenic Cell Transformation

Bader, A. G., & Vogt, P. K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.6.2095-2106.2005 · Cited by 90

mTOR Signaling in T Cell Immunity and Autoimmunity

Liu, Y., Zhang, D., & Liu, X. (2014) · International Reviews of Immunology · doi:10.3109/08830185.2014.933957 · Cited by 94

Regulation of mTOR Activity in Snell Dwarf and GH Receptor Gene-Disrupted Mice

Dominick, G., Berryman, D. E., List, E. O., Kopchick, J. J., Li, X., Miller, R. A., & Garcia, G. G. (2015) · Endocrinology · doi:10.1210/en.2014-1690 · Cited by 79

mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus

Guillén, C., & Benito, M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00621 · Cited by 91

Metabolic Health, Insulin, and Breast Cancer: Why Oncologists Should Care About Insulin

Yee, L. D., Mortimer, J. E., Natarajan, R. D., Dietze, E. C., & Seewaldt, V. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00058 · Cited by 98

Structural Basis for the Unique Biological Function of Small GTPase RHEB

Yu, Y., Li, S., Xu, X., Li, Y., Guan, K., Arnold, E., & Ding, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501253200 · Cited by 89

Postgenomic global analysis of translational control induced by oncogenic signaling

Rajasekhar, V. K., & Holland, E. C. (2004) · Oncogene · doi:10.1038/sj.onc.1207546 · Cited by 90

TSC2: filling the GAP in the mTOR signaling pathway

Li, Y. (2003) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2003.11.007 · Cited by 418

Biochemical and Functional Characterizations of Small GTPase Rheb and TSC2 GAP Activity

Li, Y., Inoki, K., & Guan, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.7965-7975.2004 · Cited by 240

Regulation of TS1/TSC2 Stability and Rheb GTP Level by Herc1

Guan, K. (2006) · doi:10.21236/ada470087

Measurements of TSC2 GAP Activity Toward Rheb

Li, Y., Inoki, K., Vikis, H. G., & Guan, K. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)07005-9 · Cited by 19

Defining the biochemical functions of the TSC complex and its regulation of Rheb-mTORC1 signaling

Lockwood, S. (2023) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)