Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083

eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

Gingras, A., Raught, B., & Sonenberg, N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.913 · Cited by 2,103

Identification and characterization of the tuberous sclerosis gene on chromosome 16

(1993) · Cell · doi:10.1016/0092-8674(93)90618-z · Cited by 1,645

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., & Cantley, L. C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00568-3 · Cited by 1,555

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

Hara, K., Yonezawa, K., Weng, Q.-P., Kozlowski, M. T., BELHAM, C. M., & Avruch, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14484 · Cited by 1,370

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

Trahey, M., & McCormick, F. (1987) · Science · doi:10.1126/science.2821624 · Cited by 1,211

FUNCTION AND REGULATION OF RAS

Lowy, D. R., & Willumsen, B. M. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.004223 · Cited by 1,164

Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., & Chen, J. (2001) · Science · doi:10.1126/science.1066015 · Cited by 1,055

Mammalian TOR: a homeostatic ATP sensor

Dennis, P. B., Jaeschke, A., Saitoh, M., Fowler, B., Kozma, S. C., & Thomas, G. (2001) · Science · doi:10.1126/science.1063518 · Cited by 962

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

Tee, A. R., Fingar, D. C., Manning, B. D., Kwiatkowski, D. J., Cantley, L. C., & Blenis, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202476899 · Cited by 827

Abnormal mTOR Activation in Autism

Winden, K. D., Ebrahimi‐Fakhari, D., & Şahin, M. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061747 · Cited by 232

mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment

Mafi, S., Mansoori, B., Taeb, S., Sadeghi, H., Abbasi, R., Cho, W. C. S., & Rostamzadeh, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.774103 · Cited by 238

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

Castel, P., Ellis, H., Bago, R., Toska, E., Razavi, P., Carmona, F. J., Kannan, S., Verma, C. S., Dickler, M. N., Chandarlapaty, S., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.06.004 · Cited by 230

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling

Peng, M., Yin, N., & Li, M. O. (2014) · Cell · doi:10.1016/j.cell.2014.08.038 · Cited by 220

AMPK–mTOR Signaling and Cellular Adaptations in Hypoxia

Chun, Y., & Kim, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189765 · Cited by 237

Phosphatidic acid signaling to mTOR: Signals for the survival of human cancer cells

Foster, D. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.02.009 · Cited by 228

Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral Nerves

Abe, N., Borson, S., Gambello, M. J., Wang, F., & Cavalli, V. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.125336 · Cited by 215

Extracellular-Regulated Kinases: Signaling From Ras to ERK Substrates to Control Biological Outcomes

Eblen, S. T. (2018) · Advances in cancer research · doi:10.1016/bs.acr.2018.02.004 · Cited by 217

S6K1 Phosphorylates and Regulates Fragile X Mental Retardation Protein (FMRP) with the Neuronal Protein Synthesis-dependent Mammalian Target of Rapamycin (mTOR) Signaling Cascade

Narayanan, U., Nalavadi, V., Nakamoto, M., Thomas, G., Ceman, S., Bassell, G. J., & Warren, S. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800055200 · Cited by 216

The role of the Birt–Hogg–Dubé protein in mTOR activation and renal tumorigenesis

Hartman, T. R., Nicolas, É., Klein–Szanto, A. J., Al‐Saleem, T., Cash, T. P., Simon, M. C., & Henske, E. P. (2009) · Oncogene · doi:10.1038/onc.2009.14 · Cited by 215

MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells

Jones, R. G., & Pearce, E. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.028 · Cited by 218

SnRK1 and TOR: modulating growth–defense trade-offs in plant stress responses

Margalha, L., Confraria, A., & Gonzalez, E. B. (2019) · Journal of Experimental Botany · doi:10.1093/jxb/erz066 · Cited by 221

The paradox of autophagy and its implication in cancer etiology and therapy

Eisenberg‐Lerner, A., & Kimchi, A. (2009) · APOPTOSIS · doi:10.1007/s10495-008-0307-5 · Cited by 220

Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1

Wang, C., Mao, X., Wang, L., Liu, M., Wetzel, M. D., Guan, K.-L., Dong, L. Q., & Liu, F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700098200 · Cited by 210

Disruption of Tsc2 in pancreatic β cells induces β cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

Rachdi, L., Balcázar, N., Osorio-Duque, F., Elghazi, L., Weiss, A., Gould, A. P., Chang-Chen, K. J., Gambello, M. J., & Bernal‐Mizrachi, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803047105 · Cited by 217

Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease

Astrinidis, A., & Henske, E. P. (2005) · Oncogene · doi:10.1038/sj.onc.1209090 · Cited by 209

Regulation of muscle protein synthesis and the effects of catabolic states

Gordon, B. S., Kelleher, A. R., & Kimball, S. R. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.05.039 · Cited by 219

How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?

Lincet, H., & Icard, P. (2014) · Oncogene · doi:10.1038/onc.2014.320 · Cited by 212

Genetically engineered human cortical spheroid models of tuberous sclerosis

Blair, J. D., Hockemeyer, D. F., & Bateup, H. S. (2018) · Nature Medicine · doi:10.1038/s41591-018-0139-y · Cited by 205

Research progress of mTOR inhibitors

Chen, Y., & Zhou, X. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112820 · Cited by 219

Distinct Signaling Events Downstream of mTOR Cooperate To Mediate the Effects of Amino Acids and Insulin on Initiation Factor 4E-Binding Proteins

Wang, X., Beugnet, A., Murakami, M., Yamanaka, S., & Proud, C. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2558-2572.2005 · Cited by 207

Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: from tuberous sclerosis to common acquired epilepsies.

Wong, M. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2009.02341.x · Cited by 205

AKT/PKB signaling mechanisms in cancer and chemoresistance

Donghwa, K. (2005) · Frontiers in bioscience · doi:10.2741/1592 · Cited by 204

Lysosomal size matters

de Araújo, M. E. G., Liebscher, G., Hess, M. W., & Huber, L. A. (2019) · Traffic · doi:10.1111/tra.12714 · Cited by 210

Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor Complex

Beevers, C. S., Chen, L., Liu, L., Luo, Y., Webster, N. J. G., & Huang, S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2367 · Cited by 208

Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder

Lombardo, M. V., Moon, H. M., Su, J., Palmer, T. D., Courchesne, E., & Pramparo, T. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.15 · Cited by 201

miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1

Hwang‐Verslues, W. W., Chang, P.-H., Wei, P.-C., Yang, C.-Y., Huang, C.-K., Kuo, W.-H., Shew, J.-Y., Chang, K.-J., Lee, E.-H., & Lee, W.-H. (2011) · Oncogene · doi:10.1038/onc.2010.618 · Cited by 205

The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor

Sodhi, A., Chaisuparat, R., Hu, J., Ramsdell, A. K., Manning, B. D., Sausville, E. A., Sawai, E. T., Molinolo, A., Gutkind, J. S., & Montaner, S. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.05.026 · Cited by 195

Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals

Miyazaki, M., & Esser, K. A. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91355.2008 · Cited by 204

Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy

Proud, C. G. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.02.003 · Cited by 198

Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein

Sato, T., Nakashima, A., Guo, L., & Tamanoi, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809207200 · Cited by 196

The lysosome: a crucial hub for AMPK and mTORC1 signalling

Carroll, B., & Dunlop, E. A. (2017) · Biochemical Journal · doi:10.1042/bcj20160780 · Cited by 192

Regulation of mRNA Translation by Signaling PathwaysPreprint

Roux, P. P., & Topisirovic, I. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012252 · Cited by 206

Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3‐kinase/Akt signalling

Miyazaki, M., McCarthy, J. J., Fedele, M. J., & Esser, K. A. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.205658 · Cited by 204

Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex

Reith, R. M., McKenna, J., Wu, H. C., Hashmi, S. S., Cho, S., Dash, P. K., & Gambello, M. J. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.10.014 · Cited by 193

TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling

Wang, B., Jie, Z., Joo, D., Ordureau, A., Liu, P., Gan, W., Guo, J., Zhang, J., North, B. J., Dai, X., et al. (2017) · Nature · doi:10.1038/nature22344 · Cited by 199

mTOR signaling in stem and progenitor cells

Meng, D., Frank, A. R., & Jewell, J. L. (2018) · Development · doi:10.1242/dev.152595 · Cited by 201

Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes

Shen, K., Huang, R. K., Brignole, E. J., Condon, K. J., Valenstein, M. L., Chantranupong, L., Bomaliyamu, A., Choe, A., Hong, C., Yu, Z., et al. (2018) · Nature · doi:10.1038/nature26158 · Cited by 192

Localization of Rheb to the endomembrane is critical for its signaling function

Buerger, C., DeVries, B., & Stambolic, V. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.220 · Cited by 192

mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions

Showkat, M., Beigh, M. A., & Andrabi, K. I. (2014) · Molecular Biology International · doi:10.1155/2014/686984 · Cited by 196

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

Carroll, B., Maetzel, D., Maddocks, O. D., Otten, G., Ratcliff, M., Smith, G. R., Dunlop, E. A., Passos, J. F., Davies, O. R., Jaenisch, R., et al. (2016) · eLife · doi:10.7554/elife.11058 · Cited by 183

Critical Role for Hypothalamic mTOR Activity in Energy Balance

Mori, H., Inoki, K., Münzberg, H., Opland, D. M., Faouzi, M., Villanueva, E. C., Ikenoue, T., Kwiatkowski, D. J., MacDougald, O. A., Myers, M. G., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.005 · Cited by 189

Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway

Wan, G., Xie, W., Liu, Z., Xu, W., Lao, Y., Huang, N., Cui, K., Liao, M., He, J., Jiang, Y., et al. (2013) · Autophagy · doi:10.4161/auto.26534 · Cited by 190

AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure

Beauloye, C., Bertrand, L., Horman, S., & Hue, L. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr034 · Cited by 191

ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

Whitney, M. L., Jefferson, L. S., & Kimball, S. R. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.079 · Cited by 199

Glycolytic Flux Signals to mTOR through Glyceraldehyde-3-Phosphate Dehydrogenase-Mediated Regulation of Rheb

Lee, M. N., Ha, S. H., Kim, J. J., Koh, A., Lee, C. S., Kim, J. H., Jeon, H., Kim, D., Suh, P., & Ryu, S. H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00165-09 · Cited by 196

Integration of Growth Factor and Nutrient Signaling

Shamji, A. F., Nghiem, P., & Schreiber, S. L. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.016 · Cited by 188

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

Yang, Q., Inoki, K., Kim, E., & Guan, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602282103 · Cited by 183

Organ Size Control by Hippo and TOR Pathways

Tumaneng, K., Russell, R. C., & Guan, K. (2012) · Current Biology · doi:10.1016/j.cub.2012.03.003 · Cited by 185

Lysosome: The metabolic signaling hub

Lamming, D. W., & Bar‐Peled, L. (2019) · Traffic · doi:10.1111/tra.12617 · Cited by 173

Training for Endurance and Strength

Baar, K. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000233799.62153.19 · Cited by 183

Interplay of energy metabolism and autophagy

Feng, Y., Chen, Y., Wu, X., Chen, J., Zhou, Q., Liu, B., Zhang, L., & Yi, C. (2023) · Autophagy · doi:10.1080/15548627.2023.2247300 · Cited by 187

Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass

Goodman, C. A., Mayhew, D. L., & Hornberger, T. A. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.07.013 · Cited by 183

The Rheb family of GTP-binding proteins

Aspuria, P.-J. P., & Tamanoi, F. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.03.019 · Cited by 181

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

Carbonneau, M., M. Gagné, L., Lalonde, M.-E., Germain, M.-A., Motorina, A., Guiot, M.-C., Secco, B., Vincent, E. E., Tumber, A., Hulea, L., et al. (2016) · Nature Communications · doi:10.1038/ncomms12700 · Cited by 180

mTOR pathway as a target in tissue hypertrophy

Lee, C.-H., Inoki, K., & Guan, K.-L. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105359 · Cited by 179

Phospholipase D1 is an effector of Rheb in the mTOR pathway

Sun, Y., Fang, Y., Yoon, M., Zhang, C., Roccio, M., Zwartkruis, F. J. T., Armstrong, M. D., Brown, H. A., & Chen, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712268105 · Cited by 184

Dendritic spine dysgenesis in autism related disorders

Phillips, M. L., & Pozzo‐Miller, L. D. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.01.011 · Cited by 188

Biphasic Response of Pancreatic β-Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice

Shigeyama, Y., Kobayashi, T., Kido, Y., Hashimoto, N., Asahara, S., Matsuda, T., Takeda, A., Inoue, T., Shibutani, Y., Koyanagi, M., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01695-07 · Cited by 184

Regulation of Body Size and Growth Control

Texada, M. J., Koyama, T., & Rewitz, K. (2020) · Genetics · doi:10.1534/genetics.120.303095 · Cited by 177

Hypoxia and aging

Yeo, E.-J. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0233-3 · Cited by 175

Getting ready for building: signaling and autophagosome biogenesis

Abada, A., & Elazar, Z. (2014) · EMBO Reports · doi:10.15252/embr.201439076 · Cited by 178

5‐HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

Meffre, J., Chaumont‐Dubel, S., la Cour, C. M., Loiseau, F., Watson, D. J., Dekeyne, A., Sevéno, M., Rivet, J., Gaven, F., Déléris, P., et al. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201410 · Cited by 185

Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle

Hornberger, T. A. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.05.007 · Cited by 170

mTORC1 signaling in hepatic lipid metabolism

Han, J., & Wang, Y. (2017) · Protein & Cell · doi:10.1007/s13238-017-0409-3 · Cited by 172

Searching for the elusive targets of farnesyltransferase inhibitors

Sebti, S. M., & Der, C. J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1234 · Cited by 170

The expanding role of mTOR in cancer cell growth and proliferation

Cargnello, M., Tcherkezian, J., & Roux, P. P. (2015) · Mutagenesis · doi:10.1093/mutage/geu045 · Cited by 172

mTOR Is Activated in the Majority of Malignant Melanomas

Karbowniczek, M., Spittle, C. S., Morrison, T., Wu, H., & Henske, E. P. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701074 · Cited by 168

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer

Knowles, M. A., Platt, F. M., Ross, R. L., & Hurst, C. D. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-009-9198-3 · Cited by 168

Autophagy in tumor suppression and cancer therapy

Kung, C.-P., Budina, A., Balaburski, G. M., Bergenstock, M., & Murphy, M. E. (2011) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v21.i1.50 · Cited by 168

Efficacy of a rapamycin analog (CCI‐779) and IFN‐γ in tuberous sclerosis mouse models

Lee, L., Sudentas, P., Donohue, B. G., Asrican, K., Worku, A. D., Walker, V., Sun, Y., Schmidt, K. F., Albert, M. S., El-Hashemite, N., et al. (2004) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20118 · Cited by 166

Role of mTOR Signaling in Female Reproduction

Guo, Z., & Yu, Q. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00692 · Cited by 172

Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK

Avivar‐Valderas, A., Bobrovnikova-Marjon, E. V., Diehl, J. A., Bardeesy, N. M., Debnath, J., & Aguirre‐Ghiso, J. A. (2012) · Oncogene · doi:10.1038/onc.2012.512 · Cited by 163

Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion

Kreuzaler, P. A., Panina, Y., Segal, J., & Yuneva, M. O. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.021 · Cited by 170

Regulating insulin signaling and β-cell function through IRS proteinsThis paper is one of a selection of papers published in this Special Issue, entitled Second Messengers and Phosphoproteins—12th International Conference.

White, M. F. (2006) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y06-008 · Cited by 164

AMP‐activated protein kinase and cancer

Wang, W., & Guan, K. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01980.x · Cited by 167

Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation.

Lu, J., Zavorotinskaya, T., Dai, Y.-M., Niu, X.-H., Castillo, J., Sim, J., Yu, J.-J., Wang, Y., Langowski, J., Holash, J., et al. (2013) · Blood · doi:10.1182/blood-2013-01-481457 · Cited by 168

Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives

Ong, P. S., Wang, L. Z., Dai, X., Tseng, S. H., Loo, S. J., & Sethi, G. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00395 · Cited by 162

Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53

Lee, C., Inoki, K., Karbowniczek, M., Petroulakis, E., Sonenberg, N., Henske, E. P., & Guan, K. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601900 · Cited by 160

Oncogenic regulation of tumor metabolic reprogramming

Tarrado‐Castellarnau, M., de Atauri, P., & Cascante, M. (2016) · Oncotarget · doi:10.18632/oncotarget.10911 · Cited by 165

Apoptosis, autophagy and atherosclerosis: Relationships and the role of Hsp27

Shan, R., Liu, N., Yan, Y., & Liu, B. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105169 · Cited by 169

The Farnesyl Transferase Inhibitor (FTI) SCH66336 (lonafarnib) Inhibits Rheb Farnesylation and mTOR Signaling

Basso, A. D., Mirza, A., Liu, G., Long, B. J., Bishop, W. R., & Kirschmeier, P. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503763200 · Cited by 162

Lysosomal recruitment of TSC2 is a universal response to cellular stress

Demetriades, C., Plescher, M., & Teleman, A. A. (2016) · Nature Communications · doi:10.1038/ncomms10662 · Cited by 160

The role of mTOR in the management of solid tumors: An overview

Strimpakos, A. S., Karapanagiotou, E. M., Saif, M. W., & Syrigos, K. (2008) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2008.09.006 · Cited by 163

The Mevalonate Pathway, a Metabolic Target in Cancer Therapy

Guerra, B., Recio, C., Aranda-Tavío, H., Guerra-Rodríguez, M., García-Castellano, J. M., & Fernández‐Pérez, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.626971 · Cited by 177

REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling

Dennis, M. D., Coleman, C. S., Berg, A., Jefferson, L. S., & Kimball, S. R. (2014) · Science Signaling · doi:10.1126/scisignal.2005103 · Cited by 159

Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

Shen, K., & Sabatini, D. M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811727115 · Cited by 165

Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Hicks, K. G., Cluntun, A. A., Schubert, H., Hackett, S. R., Berg, J. A., Leonard, P. G., Aleixo, M. A. A., Zhou, Y., Bott, A. J., Salvatore, S. R., et al. (2023) · Science · doi:10.1126/science.abm3452 · Cited by 171

Tuberous sclerosis complex: from Drosophila to human disease

Pan, D., Dong, J., Zhang, Y., & Gao, X. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2003.12.006 · Cited by 158

Functional and Phenotypic Plasticity of CD4+T Cell Subsets

Caza, T. N., & LANDAS, S. K. (2015) · BioMed Research International · doi:10.1155/2015/521957 · Cited by 168

Nutrient Sensing, Autophagy, and Diabetic Nephropathy

Kume, S., Thomas, M. C., & Koya, D. (2011) · Diabetes · doi:10.2337/db11-0555 · Cited by 157

Redox Regulates Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity by Modulating the TSC1/TSC2-Rheb GTPase Pathway

Yoshida, S., Hong, S., Suzuki, T., Nada, S., Mannan, A. M., Wang, J., Okada, M., Guan, K., & Inoki, K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.238014 · Cited by 159

Bone and skeletal muscle: Key players in mechanotransduction and potential overlapping mechanisms

Goodman, C. A., Hornberger, T. A., & Robling, A. G. (2015) · Bone · doi:10.1016/j.bone.2015.04.014 · Cited by 163

Are Wnt/β-Catenin and PI3K/AKT/mTORC1 Distinct Pathways in Colorectal Cancer?

Prossomariti, A., Piazzi, G., Alquati, C., & Ricciardiello, L. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.04.007 · Cited by 155

Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals

Segalés, J., Perdiguero, E., Serrano, A. L., Sousa-Victor, P., Ortet, L., Jardí, M., Budanov, A. V., Garcia-Prat, L., Sandri, M., Thomson, D. M., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13832-9 · Cited by 153

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

Anandapadamanaban, M., Masson, G. R., Perisic, O., Berndt, A., Kaufman, J., Johnson, C. M., Santhanam, B., Rogala, K. B., Sabatini, D. M., & Williams, R. L. (2019) · Science · doi:10.1126/science.aax3939 · Cited by 147

Small GTPases

Reiner, D. J. (2016) · WormBook · doi:10.1895/wormbook.1.67.2 · Cited by 164

mTOR function and therapeutic targeting in breast cancer.

Hare, S. H., & Harvey, A. (2017) · PubMed Central · Cited by 150

Insulin signaling pathways in cortical dysplasia and TSC‐tubers: Tissue microarray analysis

Miyata, H., Chiang, A., & Vinters, H. V. (2004) · Annals of Neurology · doi:10.1002/ana.20234 · Cited by 152

Dysregulation of the IGF‐I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders

Chen, J., Alberts, I., & Li, X. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.03.006 · Cited by 151

TSC2: filling the GAP in the mTOR signaling pathway

Li, Y. (2003) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2003.11.007 · Cited by 418

Biochemical and Functional Characterizations of Small GTPase Rheb and TSC2 GAP Activity

Li, Y., Inoki, K., & Guan, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.7965-7975.2004 · Cited by 240

Regulation of TS1/TSC2 Stability and Rheb GTP Level by Herc1

Guan, K. (2006) · doi:10.21236/ada470087

Measurements of TSC2 GAP Activity Toward Rheb

Li, Y., Inoki, K., Vikis, H. G., & Guan, K. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)07005-9 · Cited by 19

Defining the biochemical functions of the TSC complex and its regulation of Rheb-mTORC1 signaling

Lockwood, S. (2023) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)