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Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase

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IL-15–PI3K–AKT–mTOR: A Critical Pathway in the Life Journey of Natural Killer Cells

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Nutrient sensing and metabolic decisions

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TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF- Mutant Melanoma

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mTOR signaling for biological control and cancer

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The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex

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Non-canonical mTORC1 signaling at the lysosome

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Regulation of mTOR by amino acids and resistance exercise in skeletal muscle

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Specification of Neuronal Polarity Regulated by Local Translation of CRMP2 and Tau via the mTOR-p70S6K Pathway

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Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

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Role of Polyamines in Immune Cell Functions

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mTOR: A Cellular Regulator Interface in Health and Disease

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Evolution of the TOR Pathway

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Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling

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Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency

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Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer

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Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex

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The TSC-mTOR Pathway Mediates Translational Activation of TOP mRNAs by Insulin Largely in a Raptor- or Rictor-Independent Manner

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SREBP: a novel therapeutic target

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New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response

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Glucagon Represses Signaling through the Mammalian Target of Rapamycin in Rat Liver by Activating AMP-activated Protein Kinase

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The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

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Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway

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Ral and Rheb GTPase Activating Proteins Integrate mTOR and GTPase Signaling in Aging, Autophagy, and Tumor Cell Invasion

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mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells

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Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

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Growth Control Under Stress: mTOR Regulation through the REDD1-TSC Pathway

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An emerging role for TOR signaling in mammalian tissue and stem cell physiology

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PI3-kinase and TOR: PIKTORing cell growth

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ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling

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ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells

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Multi-mechanisms are involved in reactive oxygen species regulation of mTORC1 signaling

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Dengue Virus Activates the AMP Kinase-mTOR Axis To Stimulate a Proviral Lipophagy

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A Ragulator–BORC interaction controls lysosome positioning in response to amino acid availability

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Exercise-induced skeletal muscle signaling pathways and human athletic performance

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The Rap–RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

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mTORC1 Activation Regulates β-Cell Mass and Proliferation by Modulation of Cyclin D2 Synthesis and Stability

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Rheb1 Is Required for mTORC1 and Myelination in Postnatal Brain Development

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Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase

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Lysosomal adaptation: how the lysosome responds to external cues

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Cell Cycle Regulation by the Nutrient-Sensing Mammalian Target of Rapamycin (mTOR) Pathway

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Signaling from Akt to FRAP/TOR Targets both 4E-BP and S6K in Drosophila melanogaster

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Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes

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Noncanonical TGF-β pathways, mTORC1 and Abl, in renal interstitial fibrogenesis

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AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells

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Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway

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Akt Pathway Inhibitors

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mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion

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Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication

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TOR‐mediated regulation of metabolism in aging

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GABAergic Interneuron Development and Function Is Modulated by the Tsc1 Gene

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A lysosome-centered view of nutrient homeostasis

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Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity

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Role of the Phosphatidylinositol-3-Kinase and Extracellular Regulated Kinase Pathways in the Induction of Hypoxia-Inducible Factor (HIF)-1 Activity and the HIF-1 Target Vascular Endothelial Growth Factor in Ovarian Granulosa Cells in Response to Follicle-Stimulating Hormone

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mTORC2 Is Required for Proliferation and Survival of TSC2-Null Cells

Goncharova, E. A., Goncharov, D. A., Li, H., Pimtong, W., Lu, S. M., Khavin, I., & Krymskaya, V. P. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01061-10 · Cited by 122

Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies

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Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle

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Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin

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Key factors in mTOR regulation

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mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis

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Reciprocal signaling between translational control pathways and synaptic proteins in autism spectrum disorders

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Autophagy in Human Health and Disease: Novel Therapeutic Opportunities

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Activation of AMP-Activated Protein Kinase Contributes to Doxorubicin-Induced Cell Death and Apoptosis in Cultured Myocardial H9c2 Cells

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The role of autophagy in cardiovascular pathology

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Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic eventsPreprint

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Temporal Control of Differentiation by the Insulin Receptor/Tor Pathway in Drosophila

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Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington’s disease

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