The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease

Targeting HIF-1 for cancer therapy

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180

Exploiting tumour hypoxia in cancer treatment

Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828

Purification and Characterization of Hypoxia-inducible Factor 1

Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,094

Oxygen sensing by HIF hydroxylases

Schofield, C. J., & Ratcliffe, P. J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1366 · Cited by 2,068

The CBP co-activator is a histone acetyltransferase

Bannister, A. J., & Kouzarides, T. (1996) · Nature · doi:10.1038/384641a0 · Cited by 1,828

Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

Garcı́a-Barros, M., Paris, F., Cordon‐Cardo, C., Lyden, D. C., Rafii, S., Haimovitz‐Friedman, A., FUKS, Z. Y., & Kolesnick, R. (2003) · Science · doi:10.1126/science.1082504 · Cited by 1,591

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T.-Y., Huang, L. E., Pavletich, N., Chau, V., & Kaelin, W. G. (2000) · Nature Cell Biology · doi:10.1038/35017054 · Cited by 1,577

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J., & Whitelaw, M. L. (2002) · Science · doi:10.1126/science.1068592 · Cited by 1,558

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development · doi:10.1101/gad.991402 · Cited by 1,550

Nuclear Oxygen Sensing: Induction of Endogenous Prolyl-hydroxylase 2 Activity by Hypoxia and Nitric Oxide

Berchner‐Pfannschmidt, U., Tug, S., Trinidad, B., Oehme, F., Yamac, H., Wotzlaw, C., Flamme, I., & Fandrey, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804390200 · Cited by 61

Hypoxia and spermatogenesis

Veličković, L. J., & Stefanović, V. (2013) · International Urology and Nephrology · doi:10.1007/s11255-013-0601-1 · Cited by 62

Hypoxia and HIF‐1α in Chondrogenesis

Schipani, E. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1346.009 · Cited by 66

Metabolomic and lipidomic profile in men with obstructive sleep apnoea: implications for diagnosis and biomarkers of cardiovascular risk

Lebkuchen, A., Carvalho, V. M., Venturini, G., Salgueiro, J. S., Freitas, L. S., Dellavance, A., Martins, F. C., Lorenzi‐Filho, G., Cardozo, K. H. M., & Drager, L. F. (2018) · Scientific Reports · doi:10.1038/s41598-018-29727-6 · Cited by 60

Molecular Biology of Renal Cell Cancer and the Identification of Therapeutic Targets

Iliopoulos, O. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.08.8948 · Cited by 59

Therapeutic angiogenesis: From conventional approaches to recent nanotechnology-based interventions

Augustine, R., Prasad, P., & Khalaf, I. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.01.006 · Cited by 61

Pathophysiology of Contrast-Induced Acute Kidney Injury (CIAKI)

Vlachopanos, G., Schizas, D., Hasemaki, N., & Georgalis, A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191210152944 · Cited by 58

Cellular oxygen sensing, signalling and how to survive translational arrest in hypoxia

Fähling, M. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01894.x · Cited by 57

Targeting hypoxia signaling pathways in angiogenesis

Monaci, S., Coppola, F., Filippi, I., Falsini, A., Carraro, F., & Naldini, A. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1408750 · Cited by 64

Photoacoustic Imaging in Oxygen Detection

Cao, F., Qiu, Z., Li, H., & Lai, P. (2017) · Applied Sciences · doi:10.3390/app7121262 · Cited by 56

Selective Tumor Targeting by the Hypoxia-Activated Prodrug AQ4N Blocks Tumor Growth and Metastasis in Preclinical Models of Pancreatic Cancer

Lalani, A. S., Alters, S. E., Wong, A., Albertella, M. R., Cleland, J. L., & Henner, W. D. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2427 · Cited by 55

Surviving hypoxia by modulation of mRNA translation rate

Fähling, M. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00875.x · Cited by 54

BDNF Overexpression Enhances the Preconditioning Effect of Brief Episodes of Hypoxia, Promoting Survival of GABAergic Neurons

Turovskaya, M. V., Gaidin, S. G., Vedunova, M. V., Babaev, A. A., & Turovsky, E. A. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00480-z · Cited by 55

microRNAs in Cancer

Cortez, M. A., Ivan, C., Zhou, P., Wu, X., Ivan, M., & Calin, G. A. (2010) · Advances in cancer research · doi:10.1016/b978-0-12-380888-2.00004-2 · Cited by 53

Activation of the hypoxia‐inducible factor 1a promotes myogenesis through the noncanonical Wnt pathway, leading to hypertrophic myotubes

Cirillo, F., Resmini, G., Ghiroldi, A., Piccoli, M., Bergante, S., Tettamanti, G., & Anastasia, L. (2017) · The FASEB Journal · doi:10.1096/fj.201600878r · Cited by 53

IMD-0354 Targets Breast Cancer Stem Cells: A Novel Approach for an Adjuvant to Chemotherapy to Prevent Multidrug Resistance in a Murine Model

Gomez‐Cabrero, A., Wrasidlo, W., & Reisfeld, R. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073607 · Cited by 51

Hypoxia Enhances Differentiation of Mouse Embryonic Stem Cells into Definitive Endoderm and Distal Lung Cells

Pimton, P., Lecht, S., Stabler, C. T., Johannes, G. J., Schulman, E. S., & Lelkes, P. I. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0343 · Cited by 51

Accumulation of hypoxia-inducible factor-1α is limited by transcription-dependent depletion

Demidenko, Z. N., Rapisarda, A., Garayoa, M., Giannakakou, P., Melillo, G., & Blagosklonny, M. V. (2005) · Oncogene · doi:10.1038/sj.onc.1208636 · Cited by 51

Hypoxia-Inducible Factor Regulates Endothelial Metabolism in Cardiovascular Disease

Ullah, K., & Wu, R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.670653 · Cited by 50

Degradation of HIF-1alpha under Hypoxia Combined with Induction of Hsp90 Polyubiquitination in Cancer Cells by Hypericin: a Unique Cancer Therapy

Barliya, T., Mandel, M., Livnat, T., Weinberger, D., & Lavie, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022849 · Cited by 50

Gestation Dependant Changes in Angiogenic Factors and Their Associations with Fetal Growth Measures in Normotensive Pregnancy

Sundrani, D. P., Khot, V., Pisal, H., Mehendale, S. S., Wagh, G. N., Joshi, A. A., & Joshi, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054153 · Cited by 50

Turning Up The Heat: Immune Brinksmanship In The Acute-phase Response

LeGrand, E. K., & Alcock, J. (2012) · The Quarterly Review of Biology · doi:10.1086/663946 · Cited by 48

Hypoxia suppresses myocardial survival pathway through HIF-1α-IGFBP-3-dependent signaling and enhances cardiomyocyte autophagic and apoptotic effects mainly via FoxO3a-induced BNIP3 expression

Feng, C.-C., Lin, C., Lai, Y.-P., Chen, T., Shibu, M. A., Lin, J.-Y., Lin, K., Viswanadha, V. P., Kuo, W., & Huang, C. (2016) · Growth Factors · doi:10.1080/08977194.2016.1191480 · Cited by 50

Oxygen, Metabolism, and Regeneration: Lessons from Mice

Heber‐Katz, E. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.08.008 · Cited by 46

Cellular and Developmental Adaptations to Hypoxia: A Drosophila Perspective

Romero, N. M., Dekanty, A., & Wappner, P. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)35007-6 · Cited by 45

HIF1A induces expression of the WASF3 metastasis‐associated gene under hypoxic conditions

Ghoshal, P., Teng, Y., Lesoon, L. A., & Cowell, J. K. (2012) · International Journal of Cancer · doi:10.1002/ijc.27631 · Cited by 46

Microvascular Experimentation in the Chick Chorioallantoic Membrane as a Model for Screening Angiogenic Agents including from Gene-Modified Cells

Kennedy, D. C., Coen, B. A., Wheatley, A. M., & McCullagh, K. J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010452 · Cited by 46

Involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironment

Shalabi, S., Belayachi, A., & Larrivée, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1284629 · Cited by 49

Chronic Hypoxia Impairs Cytochrome Oxidase Activity Via Oxidative Stress in Selected Fetal Guinea Pig Organs

Al-Hasan, Y. M., Evans, L. C., Pinkas, G. A., Dabkowski, E. R., Stanley, W. C., & Thompson, L. P. (2012) · Reproductive Sciences · doi:10.1177/1933719112453509 · Cited by 49

Hypoxic/Normoxic Preconditioning Increases Endothelial Differentiation Potential of Human Bone Marrow CD133+ Cells

Ong, L., Li, W., Oldigs, J. K., Kaminski, A., Gerstmayer, B., Piechaczek, C., Wagner, W., Li, R., Ma, N., & Steinhoff, G. (2010) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2009.0641 · Cited by 46

Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas

Samper, E., Morgado-Palacin, L., Estrada, J. C., Bernad, A., Hubbard, A., Cadenas, S., & Melov, S. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.10.036 · Cited by 46

Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1α-VEGF signaling pathway

Ma, Z., Jin, X., Qian, Z., Li, F., Xu, M., Zhang, Y., Kang, X., Li, H., Gao, X. Y., Zhao, L., et al. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1620572 · Cited by 46

Gene transcription and chromatin regulation in hypoxia

Batie, M., & Rocha, S. (2020) · Biochemical Society Transactions · doi:10.1042/bst20191106 · Cited by 52

Deciphering Intratumoral Molecular Heterogeneity in Clear Cell Renal Cell Carcinoma with a Radiogenomics Platform

Udayakumar, D., Zhang, Z., Xi, Y., Dwivedi, D. K., Fulkerson, M., Haldeman, S., McKenzie, T., Yousuf, Q., Joyce, A., Hajibeigi, A., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-0706 · Cited by 47

Mammalian Gene Expression Program Resiliency: The Roles of Multiple Coactivator Mechanisms in Hypoxia–Responsive Transcription

Kasper, L. H., & Brindle, P. K. (2005) · Cell Cycle · doi:10.4161/cc.5.2.2353 · Cited by 44

Cavefish cope with environmental hypoxia by developing more erythrocytes and overexpression of hypoxia-inducible genes

van der Weele, C. M., & Jeffery, W. R. (2022) · eLife · doi:10.7554/elife.69109 · Cited by 44

Two functional loci in the promoter of EPAS1 gene involved in high-altitude adaptation of Tibetans

Xu, X.-H., Huang, X.-W., Li, Q., Li, Y.-N., Wang, Y., Liu, C., Ma, Y., Liu, Q.-M., Sun, K., Qian, F., et al. (2014) · Scientific Reports · doi:10.1038/srep07465 · Cited by 41

IGF binding protein 1 is correlated with hypoxia-induced growth reduce and developmental defects in grass carp (Ctenopharyngodon idellus) embryos

Sun, C., Tao, Y., Jiang, X., & Zou, S. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2011.04.005 · Cited by 43

Increasing Angiogenesis Factors in Hypoxic Diabetic Wound Conditions by siRNA Delivery: Additive Effect of LbL-Gold Nanocarriers and Desloratadine-Induced Lysosomal Escape

Shaabani, E., Sharifiaghdam, M., Lammens, J., Keersmaecker, H. D., Vervaet, C., Beer, T. D., Motevaseli, E., Ghahremani, M. H., Mansouri, P., Smedt, S. C. D., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179216 · Cited by 43

Regulation of VEGF expression by HIF-1α in the femoral head cartilage following ischemia osteonecrosis

Zhang, C., Li, Y., Cornelia, R., Swisher, S., & Kim, H. K. W. (2012) · Scientific Reports · doi:10.1038/srep00650 · Cited by 42

Telomerase activity in pregnancy complications (Review)

Fragkiadaki, P., Tsoukalas, D., Fragkiadoulaki, I., Psycharakis, C., Nikitovic, D., Spandidos, D. A., & Tsatsakis, A. M. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5231 · Cited by 41

Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression

Giaccia, A. J., & Schipani, E. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_73 · Cited by 43

EPAS1 Is Required for Spermatogenesis in the Postnatal Mouse Testis1

Gruber, M., Mathew, L. K., Runge, A., Garcia, J. A., & Simon, M. C. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.109.079202 · Cited by 42

The expanding role of BAP1 in clear cell renal cell carcinoma

Kapur, P., Rajaram, S., & Brugarolas, J. (2022) · Human Pathology · doi:10.1016/j.humpath.2022.07.022 · Cited by 41

A lipidomics investigation of the induced hypoxia stress on HeLa cells by using MS and NMR techniques

Yang, Y., Vidalino, L., Anesi, A., Macchi, P., & Guella, G. (2014) · Molecular BioSystems · doi:10.1039/c3mb70540d · Cited by 39

Proteome Analysis of Hypoxic Glioblastoma Cells Reveals Sequential Metabolic Adaptation of One-Carbon Metabolic Pathways

Zhang, K., Xu, P., Sowers, J. L., Machuca, D. F., Mirfattah, B., Herring, J. L., Tang, H. R., Chen, Y., Tian, B., Brasier, A. R., et al. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra117.000154 · Cited by 37

Hypoxia pathway has more impact than inflammation pathway on etiology of infertile men with varicocele

Ghandehari‐Alavijeh, R., Tavalaee, M., Zohrabi, D., Foroozan-Boroojeni, S., Abbasi, H., & Nasr‐Esfahani, M. H. (2018) · Andrologia · doi:10.1111/and.13189 · Cited by 39

Soluble Flt-1 Regulates Flk-1 Activation to Control Hematopoietic and Endothelial Development in an Oxygen-Responsive Manner

Purpura, K. A., George, S. H. L., Dang, S. M., Choi, K., Nagy, A., & Zandstra, P. W. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0237 · Cited by 40

Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target

Gillson, J., El-Aziz, Y. S. A., Leck, L. Y. W., Jansson, P. J., Pavlakis, N., Samra, J. S., Mittal, A., & Sahni, S. (2022) · Cancers · doi:10.3390/cancers14143528 · Cited by 38

Effects of prolyl hydroxylase inhibitors on adipogenesis and hypoxia inducible factor 1 alpha levels under normoxic conditions

Floyd, Z. E., Kilroy, G. E., Wu, X., & Gimble, J. M. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21266 · Cited by 37

Differential expression of hypoxia pathway genes in honey bee (Apis mellifera L.) caste development

de Azevedo, S. V., Carantón, O. A. M., de Oliveira, T. L., & Hartfelder, K. (2010) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2010.09.004 · Cited by 37

Targeting cancer's metabolic co-dependencies: A landscape shaped by genotype and tissue context

Bi, J., Wu, S., Zhang, W., & Mischel, P. S. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.05.002 · Cited by 37

Transcriptome Profiling Reveals Disruption of Innate Immunity in Chronic Heavy Ethanol Consuming Female Rhesus Macaques

Sureshchandra, S., Rais, M., Stull, C., Grant, K. A., & Messaoudi, I. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159295 · Cited by 36

Kv3.1 and Kv3.4, Are Involved in Cancer Cell Migration and Invasion

Song, M. S., Park, S., Park, J., Byun, J., Jin, H. K., Seo, S., Ryu, P. D., & Lee, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041061 · Cited by 36

OASIS modulates hypoxia pathway activity to regulate bone angiogenesis

Cui, M., Kanemoto, S., Cui, X., Kaneko, M., Asada, R., Matsuhisa, K., Tanimoto, K., Yoshimoto, Y., Shukunami, C., & Imaizumi, K. (2015) · Scientific Reports · doi:10.1038/srep16455 · Cited by 37

Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome

Tandle, A. T., Calvani, M., Uranchimeg, B., Zahavi, D. J., Melillo, G., & Libutti, S. K. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.03.021 · Cited by 34

Hypoxia-Induced Oxidative Stress in Health Disorders

Pialoux, V., & Mounier, R. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/940121 · Cited by 34

How plasma induced oxidation, oxygenation, and de-oxygenation influences viability of skin cells

Oh, J. S., Strudwick, X. L., Short, R. D., Ogawa, K., Hatta, A., Furuta, H., Gaur, N., Hong, S., Cowin, A. J., Fukuhara, H., et al. (2016) · Applied Physics Letters · doi:10.1063/1.4967880 · Cited by 33

MicroRNA-423 may regulate diabetic vasculopathy

Blum, A., Meerson, A., Rohana, H., Jabaly, H., Nahul, N., Celesh, D., Romanenko, O., & Tamir, S. (2019) · Clinical and Experimental Medicine · doi:10.1007/s10238-019-00573-8 · Cited by 34

Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis

Shi, Y., Liu, Z., Zhang, Q., Vallee, I., Mo, Z., Kishi, S., & Yang, X. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000991 · Cited by 31

Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma

Gao, Y., Liu, B., Feng, L., Sun, B., He, S., Yang, Y., Wu, G., Guoji, E., Liu, C., Gao, Y., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00033 · Cited by 30

The Effects of Environmental Adversities on Human Neocortical Neurogenesis Modeled in Brain Organoids

Sarieva, K., & Mayer, S. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.686410 · Cited by 30

COX2 is involved in hypoxia-induced TNF-α expression in osteoblast

Xing, Y., Wang, R., Chen, D., Mao, J., Shi, R., Wu, Z., Kang, J., Tian, W., & Zhang, C. (2015) · Scientific Reports · doi:10.1038/srep10020 · Cited by 30

Hypoxia suppresses osteogenesis of bone mesenchymal stem cells via the extracellular signal-regulated 1/2 and p38-mitogen activated protein kinase signaling pathways

Zhang, P., Ha, N., Dai, Q., Zhou, S., Yu, C., & Jiang, L. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7276 · Cited by 30

Targeting Pivotal Hallmarks of Cancer for Enhanced Therapeutic Strategies in Triple-Negative Breast Cancer Treatment—In Vitro, In Vivo and Clinical Trials Literature Review

Szulc, A., & Woźniak, M. (2024) · Cancers · doi:10.3390/cancers16081483 · Cited by 32

Hypoxia elicits broad and systematic changes in protein subcellular localization

Henke, R. M., Dastidar, R. G., Shah, A. N., Cadinu, D., Xiao, Y., Hooda, J., & Li, Z. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00481.2010 · Cited by 29

Reactive Oxygen Species-independent Oxidation of Thioredoxin in Hypoxia

Muniyappa, H., Song, S., Mathews, C. K., & Das, K. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.008557 · Cited by 28

High CO2 alters the hypoxia response of the Pacific whiteleg shrimp (Litopenaeus vannamei) transcriptome including known and novel hemocyanin isoforms

Johnson, J. G., Paul, M. R., Kniffin, C. D., Anderson, P. E., Burnett, L. E., & Burnett, K. G. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00031.2015 · Cited by 29

Roles of RUNX in Hypoxia-Induced Responses and Angiogenesis

Lee, S. H., Manandhar, S., & Lee, Y. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-3233-2_27 · Cited by 29

Expression and functional activity of pro‐oxidants and antioxidants in murine heart exposed to acute hypobaric hypoxia

Karar, J., Dolt, K. S., Mishra, M. K., Arif, E., Javed, S., & Pasha, M. A. Q. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.08.044 · Cited by 29

The biology of oxygen: Fig. 1—

Wagner, P. D. (2008) · European Respiratory Journal · doi:10.1183/09031936.00155407 · Cited by 29

Comparative transcriptome analysis reveals physiological responses in liver tissues of Epinephelus coioides under acute hypoxia stress

Lai, X., Zhang, C., Wu, Y., Yang, Y., Zhang, M., Qin, W., Wang, R., & Shu, H. (2022) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2022.101005 · Cited by 28

High oxygen prevents fetal lethality due to lack of catecholamines

Ream, M. A., Chandra, R., Peavey, M., Ray, A. M., Roffler-Tarlov, S. K., Kim, H., Wetsel, W. C., Rockman, H. A., & Chikaraishi, D. M. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00860.2007 · Cited by 28

Recent advances in ophthalmic molecular imaging

de Carvalho, E. R., Verbraak, F. D., Aalders, M. C. G., Noorden, C. J. F. V., & Schlingemann, R. O. (2013) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2013.09.005 · Cited by 27

State-of-the-art advancements in Liver-on-a-chip (LOC): Integrated biosensors for LOC

Liu, M., Xiang, Y., Yang, Y., Long, X., Xiao, Z., Nan, Y., Jiang, Y., Qiu, Y., Huang, Q., & Ai, K. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114758 · Cited by 28

Clinical, radiological, and gene expression analyses in smokers and non‐smokers, Part 2: RCT on the late healing phase of osseointegration

Sayardoust, S., Omar, O., Norderyd, O. M., & Thomsen, P. (2017) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.12514 · Cited by 26

Factors implicating the validity and interpretation of mechanobiology studies in simulated microgravity environments

Poon, C. (2020) · Engineering Reports · doi:10.1002/eng2.12242 · Cited by 25

Acute renal failure outcomes in children and adults

Radhakrishnan, J., & Kiryluk, K. (2005) · Kidney International · doi:10.1038/sj.ki.5000094 · Cited by 26

Protective effects of polyunsatutared fatty acids supplementation against testicular damage induced by intermittent hypobaric hypoxia in rats

Castillo, R. L., Zepeda, A. B., Short, S., Figueroa, E., Bustos‐Obregón, E., & Farías, J. G. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-015-0112-8 · Cited by 26

Effects of intermittent hypoxia and hyperoxia on angiogenesis and lung development in newborn mice

Elberson, V. D., Nielsen, L. C., Wang, H., & Kumar, V. (2016) · Journal of Neonatal-Perinatal Medicine · doi:10.3233/npm-15814134 · Cited by 26

Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma

Joshi, S., Singh, A. R., & Durden, D. L. (2015) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-014-2639-x · Cited by 25

Physiological Hypoxia (Physioxia) Impairs the Early Adhesion of Single Lymphoma Cell to Marrow Stromal Cell and Extracellular Matrix. Optical Tweezers Study

Duś‐Szachniewicz, K., Drobczyński, S., Ziolkowski, P. P., Kołodziej, P., Walaszek, K., Korzeniewska, A. K., Agrawal, A. K., Kupczyk, P., & Woźniak, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071880 · Cited by 25

Inheritance and memory of stress‐induced epigenome change: roles played by the ATF‐2 family of transcription factors

Seong, K., Maekawa, T., & Ishii, S. (2012) · Genes to Cells · doi:10.1111/j.1365-2443.2012.01587.x · Cited by 26

Chromium oxide nanoparticle–induced biochemical and histopathological alterations in the kidneys and brain of Wistar rats

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Enhancing proliferation and optimizing the culture condition for human bone marrow stromal cells using hypoxia and fibroblast growth factor-2

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