The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Cell population heterogeneity during growth of Bacillus subtilis
Open accessAbstract
We have discovered that cells of Bacillus subtilis at the mid-exponential phase of growth are a mixed population of two strikingly different cell types. One type is single swimming cells (or cell doublets) in which the transcription factor for motility, σ D , is active (σ D ON). The other type is long chains of sessile cells in which σ D is inactive (σ D OFF). The population is strongly biased toward σ D -ON cells by the action of a novel regulatory protein called SwrA. SwrA stimulates the transcription of a large operon (the flagellum/chemotaxis operon), which includes the genes for σ D and an activator of σ D -directed gene expression, SwrB. Cell population heterogeneity could enable B. subtilis to exploit its present location through the production of sessile cells as well as to explore new environmental niches through the generation of nomadic cells.
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Cites
Bacterial Persistence as a Phenotypic Switch
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952 · cited 1×
“For example, Escherichia coli cells can spontaneously enter a “persister” state in which some cells in the population temporarily stop growing and, as a consequence, escape the killing action of -lactam antibiotics (Balaban et al. 2004; Keren et al. 2004).”
BackgroundFerrell, J. E. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00314-9 · Cited by 1,131
Fruiting body formation by Bacillus subtilis
Branda, S. S., González-Pastor, J. E., Ben-Yehuda, S., Losick, R., & Kolter, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191384198 · Cited by 1,129
Self-citationSpecialized Persister Cells and the Mechanism of Multidrug Tolerance in Escherichia coli
Keren, I., Shah, D., Spoering, A., Kaldalu, N., & Lewis, K. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.24.8172-8180.2004 · Cited by 856
A master regulator for biofilm formation by Bacillus subtilis
Kearns, D. B., Chu, F., Branda, S. S., Kolter, R., & Losick, R. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04440.x · Cited by 597
Self-citationCannibalism by sporulating bacteria.
González-Pastor, J. E., Hobbs, E. C., & Losick, R. (2003) · Science · doi:10.1126/science.1086462 · Cited by 579
Self-citationSwarming motility in undomesticated Bacillus subtilis
Kearns, D. B., & Losick, R. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03584.x · Cited by 551
Self-citationMolecular switches — the ON and OFF of bacterial phase variation
Henderson, I. R., Owen, P., & Nataro, J. P. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01555.x · Cited by 501
Sensing structural intermediates in bacterial flagellar assembly by export of a negative regulator
Hughes, K., Gillen, K., Semon, M., & Karlinsey, J. (1993) · Science · doi:10.1126/science.8235660 · Cited by 484
High- and Low-Threshold Genes in the Spo0A Regulon of Bacillus subtilis
Fujita, M., González-Pastor, J. E., & Losick, R. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.4.1357-1368.2005 · Cited by 427
Self-citation
Cited by
A field guide to bacterial swarming motility
Kearns, D. B. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2405 · Cited by 1,483
Self-citationOral multispecies biofilm development and the key role of cell–cell distance
Kolenbrander, P. E., Palmer, R. J., Periasamy, S., & Jakubovics, N. S. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2381 · Cited by 1,309
Microbial Cell Individuality and the Underlying Sources of Heterogeneity
Avery, S. V. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1460 · Cited by 521
Generation of multiple cell types in Bacillus subtilis
Lopez, D., Vlamakis, H., & Kolter, R. (2009) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00148.x · Cited by 381
Bet Hedging in Yeast by Heterogeneous, Age-Correlated Expression of a Stress Protectant
Levy, S. F., Ziv, N., & Siegal, M. L. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001325 · Cited by 371
Metadata
- Authors
- Kearns, D. B., & Losick, R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-12-15
- Volume
- 19
- Issue
- 24
- Pages
- 3083-3094
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2133397415
- Cited by
- 358
- References
- 35
- Type
- posted content
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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