Cited by 308DNA Repair MechanismsBRCA gene mutations in cancerPARP inhibition in cancer therapy

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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

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Greenberg, Roger A., Sobhian, Bijan, Pathania, Shailja, Cantor, Sharon B., Nakatani, Yoshihiro, Livingston, David M.·2006·Genes & Development

DOI 10.1101/gad.1381306PMC PMC1356099

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Abstract

The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA damage is poorly understood. Following exposure to genotoxic stress, DNA damage-specific interactions were observed between BRCA1/BARD1 and the DNA damage-response proteins, TopBP1 and Mre11/Rad50/NBS1. Two distinct DNA damage-dependent super complexes emerged; their activation was dependent, in part, on the actions of specific checkpoint kinases, and each super complex contributed to a distinctive aspect of the DNA damage response. The results support a new, multifactorial model that describes how genotoxic stress enables BRCA1 to execute a diverse set of DNA damage-response functions.

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Authors: Greenberg, R. A., Sobhian, B., Pathania, S., Cantor, S. B., Nakatani, Y., & Livingston, D. M.
Affiliations: Harvard University (US)
ORCID: Greenberg, Roger A.
Sobhian, Bijan
Pathania, Shailja
Cantor, Sharon B.
Livingston, David M.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2006-01-01
Volume: 20
Issue: 1
Pages: 34-46
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1381306
PMC: PMC1356099
OpenAlex: W2164458581
Cited by: 308
References: 61
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 12 · 2021: 17 · 2020: 13 · 2019: 4 · 2018: 14 · 2017: 12 · 2016: 10 · 2015: 19 · 2014: 21 · 2013: 19 · 2012: 22
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship@UMassChan (submittedVersion)
Funders: Leukemia Research Foundation
Broad Institute
Österreichischen Akademie der Wissenschaften
National Cancer Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: BRCA1, BARD1, DNA damage response, TopBP1, Mre11-Rad50-Nbs1, checkpoint kinase, genotoxic stress
MeSH terms: MRE11 Homologue Protein, Carrier Proteins, Cell Cycle, DNA Damage, DNA Repair, DNA-Binding Proteins, Humans, Nuclear Proteins, Protein Binding, Acid Anhydride Hydrolases, Cell Cycle Proteins, BRCA1 Protein, Tumor Suppressor Proteins, Ubiquitin-Protein Ligases, DNA Repair Enzymes, Cell Line, Tumor

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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

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