Cited by 286Developmental Biology and Gene RegulationGenomics and Chromatin DynamicsGene Regulatory Network Analysis

The DOI matches its Crossref record; 75 of the 76 references it cites were found in a registry or an index.

A core transcriptional network for early mesoderm development in Drosophila melanogaster

Open access

Sandmann, Thomas, Girardot, Charles, Brehme, Marc, Tongprasit, Waraporn, Stolc, Viktor, Furlong, Eileen E.M.·2007·Genes & Development

DOI 10.1101/gad.1509007PMC PMC1804332

Open this paper in CoChat — free account Open PDF

Abstract

Embryogenesis is controlled by large gene-regulatory networks, which generate spatially and temporally refined patterns of gene expression. Here, we report the characteristics of the regulatory network orchestrating early mesodermal development in the fruitfly Drosophila , where the transcription factor Twist is both necessary and sufficient to drive development. Through the integration of chromatin immunoprecipitation followed by microarray analysis (ChIP-on-chip) experiments during discrete time periods with computational approaches, we identified >2000 Twist-bound cis -regulatory modules (CRMs) and almost 500 direct target genes. Unexpectedly, Twist regulates an almost complete cassette of genes required for cell proliferation in addition to genes essential for morophogenesis and cell migration. Twist targets almost 25% of all annotated Drosophila transcription factors, which may represent the entire set of regulators necessary for the early development of this system. By combining in vivo binding data from Twist, Mef2, Tinman, and Dorsal we have constructed an initial transcriptional network of early mesoderm development. The network topology reveals extensive combinatorial binding, feed-forward regulation, and complex logical outputs as prevalent features. In addition to binary activation and repression, we suggest that Twist binds to almost all mesodermal CRMs to provide the competence to integrate inputs from more specialized transcription factors.

Integrity signals

Registry

Crossref · 10.1101/gad.1509007

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568
TM4: a free, open-source system for microarray data management and analysis
Saeed, A. I., Sharov, V., White, J., Li, J., Liang, W., Bhagabati, N., Braisted, J., Klapa, M., Currier, T., Thiagarajan, M., et al. (2003) · BioTechniques · doi:10.2144/03342mt01 · Cited by 4,837
Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
Boyer, L. A., Lee, T. I., Cole, M. F., Johnstone, S. E., Levine, S. S., Zucker, J. P., Guenther, M. G., Kumar, R. M., Murray, H. L., Jenner, R. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.020 · Cited by 4,505
Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Yang, J., Mani, S. A., Donaher, J. L., Ramaswamy, S., Itzykson, R., Côme, C., Savagner, P., Gitelman, I., Richardson, A. L., & Weinberg, R. A. (2004) · Cell · doi:10.1016/j.cell.2004.06.006 · Cited by 3,917
TRANSFAC(R) and its module TRANSCompel(R): transcriptional gene regulation in eukaryotes
Matys, V. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj143 · Cited by 2,142
[9] TM4 Microarray Software Suite
Saeed, A. I., BHAGABATI, N. K., Braisted, J. C., Liang, W. P., Sharov, V., Howe, E., Li, J., Thiagarajan, M., White, J., & Quackenbush, J. F. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)11009-5 · Cited by 1,996
Genome-Wide Location and Function of DNA Binding Proteins
Ren, B., Robert, F., Wyrick, J. J., Aparicio, O. M., Jennings, E. G., Simon, I., Zeitlinger, J., Schreiber, J., Hannett, N. M., Kanin, E. I., et al. (2000) · Science · doi:10.1126/science.290.5500.2306 · Cited by 1,768
A genomic regulatory network for development
Davidson, E. H., Rast, J. P., Oliveri, P., Ransick, A., Calestani, C., Yuh, C.-H., Minokawa, T., Amore, G., Hinman, V., Arenas-Mena, C., et al. (2002) · Science · doi:10.1126/science.1069883 · Cited by 1,567
Control of Pancreas and Liver Gene Expression by HNF Transcription Factors
Odom, D. T., Zizlsperger, N., Gordon, D. B., Bell, G. W., Rinaldi, N. J., Murray, H. L., Volkert, T. L., Schreiber, J., Rolfe, A., Gifford, D. K., et al. (2004) · Science · doi:10.1126/science.1089769 · Cited by 1,348
Identifying DNA and protein patterns with statistically significant alignments of multiple sequences.
Hertz, G. Z., & Stormo, G. D. (1999) · Bioinformatics · doi:10.1093/bioinformatics/15.7.563 · Cited by 1,246
A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome
Wei, C.-L., Wu, Q., Vega, V. B., Chiu, K. P., Ng, P., Zhang, T., Shahab, A., Yong, H. C., Fu, Y., Weng, Z., et al. (2006) · Cell · doi:10.1016/j.cell.2005.10.043 · Cited by 1,141
A Twist Code Determines the Onset of Osteoblast Differentiation
Bialek, P., Kern, B., Yang, X., Schrock, M., Šošić, D., Hong, N. A., Wu, H., Yu, K., Ornitz, D. M., Olson, E. N., et al. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00058-9 · Cited by 674
twist and snail as positive and negative regulators during Drosophila mesoderm development.Preprint
Leptin, M. (1991) · Genes & Development · doi:10.1101/gad.5.9.1568 · Cited by 571
The Coherent Feedforward Loop Serves as a Sign-sensitive Delay Element in Transcription Networks
Mangan, S., Zaslaver, A., & Alon, U. S. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.09.049 · Cited by 548
Cell shape changes during gastrulation in Drosophila
Leptin, M., & Grunewald, B. (1990) · Development · doi:10.1242/dev.110.1.73 · Cited by 542
Genetics of craniofacial development and malformation
Wilkie, A. O. M., & Morriss‐Kay, G. M. (2001) · Nature Reviews Genetics · doi:10.1038/35076601 · Cited by 442
Detection of functional DNA motifs via statistical over-representation
Frith, M. C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh299 · Cited by 424
Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growthPreprint
Sokol, N. S., & Ambros, V. (2005) · Genes & Development · doi:10.1101/gad.1356105 · Cited by 402
Regulatory Blueprint for a Chordate Embryo
Imai, K. S., Levine, M., Satoh, N., & Satou, Y. (2006) · Science · doi:10.1126/science.1123404 · Cited by 394
Gene Expression Analysis Using Oligonucleotide Arrays Produced by Maskless PhotolithographyPreprint
Nuwaysir, E. F., Huang, W., Albert, T. J., Singh, J., Nuwaysir, K., Pitas, A., Richmond, T., Gorski, T., Berg, J. P., Ballin, J. D., et al. (2002) · Genome Research · doi:10.1101/gr.362402 · Cited by 364
GFP and β-Galactosidase Transformation Vectors for Promoter/Enhancer Analysis in Drosophila
Barolo, S., Carver, L. A., & Posakony, J. W. (2000) · BioTechniques · doi:10.2144/00294bm10 · Cited by 339
Promoter-Specific Regulation of MyoD Binding and Signal Transduction Cooperate to Pattern Gene Expression
Bergstrom, D. A., Penn, B. H., Strand, A. D., Perry, R. L., Rudnicki, M. A., & Tapscott, S. J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00481-1 · Cited by 332
Pbx Marks Genes for Activation by MyoD Indicating a Role for a Homeodomain Protein in Establishing Myogenic Potential
Berkes, C. A., Bergstrom, D. A., Penn, B. H., Seaver, K. J., Knoepfler, P. S., & Tapscott, S. J. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00260-6 · Cited by 332
twist : A Myogenic Switch in Drosophila
Baylies, M. K., & Bate, M. (1996) · Science · doi:10.1126/science.272.5267.1481 · Cited by 331
The prospero gene encodes a divergent homeodomain protein that controls neuronal identity in Drosophila.
Chu‐LaGraff, Q., Wright, D. M., McNeil, L. K., & Doe, C. Q. (1991) · PubMed · Cited by 328
The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo.Preprint
Ip, Y. T., Park, R., Kosman, D., Bier, E., & Levine, M. (1992) · Genes & Development · doi:10.1101/gad.6.9.1728 · Cited by 324
The Incoherent Feed-forward Loop Accelerates the Response-time of the gal System of Escherichia coli
Mangan, S., Itzkovitz, S., Zaslaver, A., & Alon, U. S. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.12.003 · Cited by 321
dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo.Preprint
Ip, Y. T., Park, R., Kosman, D., Yazdanbakhsh, K., & Levine, M. (1992) · Genes & Development · doi:10.1101/gad.6.8.1518 · Cited by 313
The twist gene: isolation of a Drosophila zygotle gene necessary for the establishment of dorsoventral pattern
Thisse, B., Messal, M. E., & Perrin‐Schmitt, F. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.8.3439 · Cited by 311
Whole-genome analysis of dorsal-ventral patterning in the Drosophila embryo.
Stathopoulos, A., Drenth, M. V., Erives, A. J., Markstein, M., & Levine, M. (2002) · Cell · doi:10.1016/s0092-8674(02)01087-5 · Cited by 310
A Gene Expression Map for the Euchromatic Genome of Drosophila melanogaster
Štolc, V., Gauhar, Z., Mason, C. E., Halasz, G., van Batenburg, M. F., Rifkin, S. A., Hua, S., Herreman, T., Tongprasit, W., Barbano, P. E., et al. (2004) · Science · doi:10.1126/science.1101312 · Cited by 290
Self-citation
Patterns of Gene Expression During Drosophila Mesoderm Development
Furlong, E., Andersen, E. C., Null, B. H., White, K., & Scott, M. (2001) · Science · doi:10.1126/science.1062660 · Cited by 286
Self-citation
Whole-genome ChIP–chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryo
Zeitlinger, J., Zinzen, R. P., Stark, A., Kellis, M., Zhang, H., Young, R. A., & Levine, M. (2007) · Genes & Development · doi:10.1101/gad.1509607 · Cited by 286
Cells with persistent twist expression are the embryonic precursors of adult muscles in Drosophila
Bate, M., Rushton, E., & Currie, D. A. (1991) · Development · doi:10.1242/dev.113.1.79 · Cited by 254
Chromosomal Distribution of PcG Proteins during Drosophila Development
Negre, N. N., Hennetin, J., Sun, L. V., Lavrov, S. A., Bellis, M., White, K. P., & Cavalli, G. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040170 · Cited by 246
Transcriptional Control in the Segmentation Gene Network of Drosophila
Schroeder, M. D., Pearce, M., Fak, J. J., Fan, H., Unnerstall, U., Emberly, E. G., Rajewsky, N., Siggia, E. D., & Gaul, U. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020271 · Cited by 241
A Gene-Centered C. elegans Protein-DNA Interaction Network
Deplancke, B., Mukhopadhyay, A., Ao, W., Elewa, A., Grove, C. A., Martinez, N. J., Sequerra, R., Doucette‐Stamm, L., Reece-Hoyes, J. S., Hope, I. A., et al. (2006) · Cell · doi:10.1016/j.cell.2006.04.038 · Cited by 240
TileMap: create chromosomal map of tiling array hybridizations
Ji, H., & Wong, W. H. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti593 · Cited by 238
A Temporal Map of Transcription Factor Activity: Mef2 Directly Regulates Target Genes at All Stages of Muscle Development
Sandmann, T., Jensen, L. J., Jakobsen, J. S., Karzynski, M., Eichenlaub, M., Peer Bork, B., & Furlong, E. E. M. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.009 · Cited by 233
Self-citation
A new generation of JASPAR, the open-access repository for transcription factor binding site profiles
Vlieghe, D. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj115 · Cited by 230
Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins
Kidd, S. (1992) · Cell · doi:10.1016/0092-8674(92)90596-5 · Cited by 227
Genomic Regulatory Networks and Animal Development
Stathopoulos, A., & Levine, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.005 · Cited by 223
A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiationPreprint
Penn, B. H., Bergstrom, D. A., Dilworth, F. J., Bengal, E., & Tapscott, S. J. (2004) · Genes & Development · doi:10.1101/gad.1234304 · Cited by 193
Drosophila DNase I footprint database: a systematic genome annotation of transcription factor binding sites in the fruitfly, Drosophila melanogaster
Bergman, C., Carlson, J., & Celniker, S. (2004) · Computer applications in the biosciences · doi:10.1093/bioinformatics/bti173 · Cited by 188
Regulation of the Twist target gene tinman by modular cis-regulatory elements during early mesoderm development
Yin, Z., Xu, X.-L., & Frasch, M. (1997) · Development · doi:10.1242/dev.124.24.4971 · Cited by 184
pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryosPreprint
Stathopoulos, A., Tam, B., Ronshaugen, M., Frasch, M., & Levine, M. (2004) · Genes & Development · doi:10.1101/gad.1166404 · Cited by 169
A regulatory code for neurogenic gene expression in the Drosophila embryo
Markstein, M., Zinzen, R., Markstein, P., Yee, K.-P., Erives, A., Stathopoulos, A., & Levine, M. (2004) · Development · doi:10.1242/dev.01124 · Cited by 165
Computational Models for Neurogenic Gene Expression in the Drosophila Embryo
Zinzen, R. P., Senger, K., Levine, M., & Papatsenko, D. (2006) · Current Biology · doi:10.1016/j.cub.2006.05.044 · Cited by 165
Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development
Castanon, I., Stetina, S. E. V., Kass, J. I., & Baylies, M. K. (2001) · Development · doi:10.1242/dev.128.16.3145 · Cited by 160
The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesisPreprint
Cripps, R. M., Black, B. L., Zhao, B., Lien, C., Schulz, R. A., & Olson, E. N. (1998) · Genes & Development · doi:10.1101/gad.12.3.422 · Cited by 154
Lineage analysis of transplanted individual cells in embryos of Drosophila melanogaster
Beer, J., Technau, G. M., & Campos‐Ortega, J. A. (1987) · Development Genes and Evolution · doi:10.1007/bf00376346 · Cited by 130
Altered mitotic domains reveal fate map changes in Drosophila embryos mutant for zygotic dorsoventral patterning genes
Arora, K., & Nüsslein‐Volhard, C. (1992) · Development · doi:10.1242/dev.114.4.1003 · Cited by 124
The Mesoderm Specification Factor Twist in the Life Cycle of Jellyfish
Spring, J., Yanze, N., Middel, A. M., Stierwald, M., Gröger, H., & Schmid, V. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9956 · Cited by 115
Dorsal-Mediated Repression Requires the Formation of a Multiprotein Repression Complex at the Ventral Silencer
Valentine, S. A., Chen, G., Shandala, T., Fernandez, J., Mische, S., Saint, R., & Courey, A. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6584 · Cited by 114
Anterior-posterior subdivision and the diversification of the mesoderm in Drosophila
Dunin-Borkowski, O. M., Brown, N. H., & Bate, M. (1995) · Development · doi:10.1242/dev.121.12.4183 · Cited by 111
Xenopus as a model system to study transcriptional regulatory networks
Koide, T., Hayata, T., & Cho, K. W. Y. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408125102 · Cited by 96
Whole-Genome Analysis of Temporal Gene Expression during Foregut Development
Gaudet, J., Muttumu, S., Horner, M. A., & Mango, S. E. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020352 · Cited by 92
Automated sorting of live transgenic embryos
Furlong, E. E. M., Profitt, D., & Scott, M. P. (2001) · Nature Biotechnology · doi:10.1038/84422 · Cited by 92
Self-citation
Spatial regulation of microRNA gene expression in the Drosophila embryo
Biemar, F., Zinzen, R. P., Ronshaugen, M., Sementchenko, V. I., Manak, J. R., & Levine, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507817102 · Cited by 87
The maternal NF-κB/Dorsal gradient of Tribolium castaneum: dynamics of early dorsoventral patterning in a short-germ beetle
Chen, G., Handel, K., & Roth, S. (2000) · Development · doi:10.1242/dev.127.23.5145 · Cited by 85
Quantitative analysis of binding motifs mediating diverse spatial readouts of the Dorsal gradient in the Drosophila embryo
Papatsenko, D., & Levine, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409414102 · Cited by 82
Genomic analysis of heat-shock factor targets in Drosophila
Birch‐Machin, I., Gao, S., Huen, D. S., McGirr, R., H.White, R. A., & Russell, S. R. H. (2005) · Genome biology · doi:10.1186/gb-2005-6-7-r63 · Cited by 82
DrosophilaWntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo
Ganguly, A., Jiang, J., & Ip, Y. T. (2005) · Development · doi:10.1242/dev.01903 · Cited by 81
REDfly: a Regulatory Element Database for Drosophila
Gallo, S. M., Li, L., Hu, Z., & Halfon, M. S. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti794 · Cited by 80
Twist-mediated Activation of the NK-4 Homeobox Gene in the Visceral Mesoderm of Drosophila Requires Two Distinct Clusters of E-box Regulatory Elements
Lee, Y. M., Park, T., Schulz, R. A., & Kim, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17531 · Cited by 65
Transcriptional network underlying Caenorhabditis elegans vulval development
Inoue, T., Wang, M., Ririe, T. O., Fernandes, J. S., & Sternberg, P. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408122102 · Cited by 61
A Direct Contact between the Dorsal rel Homology Domain and Twist May Mediate Transcriptional Synergy
Shirokawa, J. M., & Courey, A. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.6.3345 · Cited by 50
Identification of novel genes in Drosophila reveals the complex regulation of early gene activity in the mesoderm.
Casal, J. I., & Leptin, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10327 · Cited by 46
Combinatorial control of Drosophila mef2 gene expression in cardiac and somatic muscle cell lineages
Gajewski, K. M., Kim, Y., Choi, C. Y., & Schulz, R. A. (1998) · Development Genes and Evolution · doi:10.1007/s004270050194 · Cited by 45
Specification of the Drosophila CNS midline cell lineage: direct control of single-minded transcription by dorsal/ventral patterning genes.
(1998) · Europe PMC (PubMed Central) · Cited by 43
A Drosophila model to study the functions of TWIST orthologs in apoptosis and proliferation
Gullaud, M., Delanoue, R., & Silber, J. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401222 · Cited by 21
Characterisation of T48, a target of homeotic gene regulation in Drosophila embryogenesis
Strutt, D. I., & White, R. A. (1994) · Mechanisms of Development · doi:10.1016/0925-4773(94)90035-3 · Cited by 19
Genome-wide Mapping of in Vivo Targets of the Drosophila Transcription Factor Krüppel
Matyash, A., Chung, H., & Jäckle, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403345200 · Cited by 14
Laser ablation of persistent twist cells inDrosophila: muscle precursor fate is not segmentally restricted
Farrell, E. R., & Keshishian, H. (1999) · Development · doi:10.1242/dev.126.2.273 · Cited by 14

Research works printed but not linked: 1

Davidson, E.H. (2006) The regulatory genome (Academic Press, Burlington, MA).

Sorted by citations

Transcription factors: from enhancer binding to developmental control
Spitz, F., & Furlong, E. E. M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3207 · Cited by 2,227
Self-citation
Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution
Carroll, S. B. (2008) · Cell · doi:10.1016/j.cell.2008.06.030 · Cited by 2,067
Transcriptional enhancers: from properties to genome-wide predictions
Shlyueva, D., Stampfel, G., & Stark, A. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3682 · Cited by 1,356
MEF2: a central regulator of diverse developmental programs
Potthoff, M. J., & Olson, E. N. (2007) · Development · doi:10.1242/dev.008367 · Cited by 834
A brassinosteroid transcriptional network revealed by genome‐wide identification of BESI target genes in Arabidopsis thaliana
Yu, X., Li, L., Żola, J., Aluru, M. R., Ye, H., Foudree, A., Guo, H., Anderson, S. N., Aluru, S., Liu, P., et al. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04449.x · Cited by 660

See all 286

Authors: Sandmann, T., Girardot, C., Brehme, M., Tongprasit, W., Stolc, V., & Furlong, E. E. M.
Affiliations: European Molecular Biology Laboratory (DE)
Ames Research Center (US)
ORCID: Sandmann, Thomas
Girardot, Charles
Brehme, Marc
Furlong, Eileen E.M.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2007-02-15
Volume: 21
Issue: 4
Pages: 436-449
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1509007
PMC: PMC1804332
OpenAlex: W2127043599
Cited by: 286
References: 76
Citations by year: 2026: 4 · 2025: 6 · 2024: 2 · 2023: 4 · 2022: 8 · 2021: 18 · 2020: 7 · 2019: 14 · 2018: 14 · 2017: 10 · 2016: 15 · 2015: 19 · 2014: 17 · 2013: 13 · 2012: 21
Type: posted content
Language: en
Open access: hybrid
doi.org
Licence: other-oa
Locations: Genes & Development (publishedVersion, other-oa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords: Twist transcription factor, Drosophila melanogaster, cis-regulatory modules, transcriptional regulatory networks, direct target genes, MEF2, tinman, Dorsal, feedforward control, cell proliferation, cell migration, morphogenesis, network topology
MeSH terms: Animals, Drosophila melanogaster, Enhancer Elements, Genetic, Mesoderm, Gene Expression Regulation, Developmental, Drosophila Proteins, Embryonic Development, Chromatin Immunoprecipitation, Twist-Related Protein 1, Gene Regulatory Networks

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A core transcriptional network for early mesoderm development in Drosophila melanogaster

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks