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Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells

Loh, Yuin-Han, Zhang, Weiwei, Chen, Xi, George, Joshy, Ng, Huck-Hui·2007·Genes & Development
DOI 10.1101/gad.1588207
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Abstract

Embryonic stem (ES) cells are pluripotent cells with the ability to self-renew indefinitely. These unique properties are controlled by genetic factors and chromatin structure. The exit from the self-renewing state is accompanied by changes in epigenetic chromatin modifications such as an induction in the silencing-associated histone H3 Lys 9 dimethylation and trimethylation (H3K9Me2/Me3) marks. Here, we show that the H3K9Me2 and H3K9Me3 demethylase genes, Jmjd1a and Jmjd2c, are positively regulated by the ES cell transcription factor Oct4. Interestingly, Jmjd1a or Jmjd2c depletion leads to ES cell differentiation, which is accompanied by a reduction in the expression of ES cell-specific genes and an induction of lineage marker genes. Jmjd1a demethylates H3K9Me2 at the promoter regions of Tcl1, Tcfcp2l1, and Zfp57 and positively regulates the expression of these pluripotency-associated genes. Jmjd2c acts as a positive regulator for Nanog, which encodes for a key transcription factor for self-renewal in ES cells. We further demonstrate that Jmjd2c is required to reverse the H3K9Me3 marks at the Nanog promoter region and consequently prevents transcriptional repressors HP1 and KAP1 from binding. Our results connect the ES cell transcription circuitry to chromatin modulation through H3K9 demethylation in pluripotent cells.

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  1. 10.1101/gad.224503 · DOI
  2. 10.1038/ncb1403 · DOI
  3. 10.1038/35065138 · DOI · Paper page
  4. 10.1016/j.cell.2005.08.020 · DOI · Paper page
  5. 10.1016/S0092-8674(03)00392-1 · DOI
  6. 10.1128/MCB.25.14.6031-6046.2005 · DOI
  7. 10.1038/nature04837 · DOI
  8. 10.1128/MCB.24.6.2478-2486.2004 · DOI
  9. 10.1038/35102154 · DOI
  10. 10.1101/gad.388206 · DOI
  11. 10.1016/j.cell.2007.03.014 · DOI · Paper page
  12. 10.1126/science.1073823 · DOI
  13. 10.1038/nature04915 · DOI
  14. 10.1038/nature04853 · DOI
  15. 10.1016/S0955-0674(02)00335-6 · DOI
  16. 10.1002/gene.10250 · DOI
  17. 10.1091/mbc.E06-07-0624 · DOI
  18. 10.1016/S0012-1606(03)00390-7 · DOI
  19. 10.1038/ng1760 · DOI
  20. 10.1016/j.stem.2007.05.014 · DOI · Paper page
  21. 10.1038/nrm1761 · DOI
  22. 10.1371/journal.pone.0000026 · DOI
  23. 10.1038/nrm1938 · DOI
  24. 10.1016/j.devcel.2005.10.017 · DOI
  25. 10.1016/S0092-8674(03)00393-3 · DOI
  26. 10.1016/S0092-8674(00)81769-9 · DOI
  27. 10.1242/dev.02787 · DOI
  28. 10.1128/MCB.21.13.4330-4336.2001 · DOI
  29. 10.1038/nature05934 · DOI
  30. 10.1006/dbio.1994.1312 · DOI
  31. 10.1128/MCB.01432-06 · DOI
  32. 10.1126/science.1072530 · DOI
  33. Ryan,, 1999, KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: A potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing, Mol. Cell. Biol., 19, 4366, 10.1128/MCB.19.6.4366 · DOI
  34. 10.1016/j.molcel.2006.12.010 · DOI
  35. 10.1146/annurev.cellbio.17.1.435 · DOI
  36. 10.1101/gad.989402 · DOI
  37. 10.1016/j.cell.2006.04.003 · DOI
  38. 10.1038/nature04433 · DOI
  39. 10.1016/S0092-8674(02)01080-2 · DOI · Paper page
  40. 10.1038/nature05284 · DOI
  41. 10.1038/nature05944 · DOI
  42. 10.1016/j.cell.2006.03.028 · DOI
  43. 10.1074/jbc.C600122200 · DOI
  44. 10.1016/j.cell.2006.03.027 · DOI

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Metadata

Authors
Loh, Y.-H., Zhang, W., Chen, X., George, J., & Ng, H.-H.
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
2007-10-15
Volume
21
Issue
20
Pages
2545-2557
ISSN
  • 0890-9369
  • 1549-5477
DOI
10.1101/gad.1588207
Cited by
443
References
5
Language
en

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