Chk1 and Claspin potentiate PCNA ubiquitination

The DNA damage response: putting checkpoints in perspective

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Global Mapping of the Yeast Genetic Interaction Network

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PCNA, the Maestro of the Replication Fork

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ATR and ATRIP: Partners in Checkpoint Signaling

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Interaction of Human DNA Polymerase η with Monoubiquitinated PCNA

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GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

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S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

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Regulation of monoubiquitinated PCNA by DUB autocleavage

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Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions

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Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

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Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination

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Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatinPreprint

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Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53Preprint

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Mrc1 and Tof1 Promote Replication Fork Progression and Recovery Independently of Rad53

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Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression

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The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement

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Mrc1 Is Required for Normal Progression of Replication Forks throughout Chromatin in S. cerevisiae

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Claspin Operates Downstream of TopBP1 To Direct ATR Signaling towards Chk1 Activation

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Chk1 Requirement for High Global Rates of Replication Fork Progression during Normal Vertebrate S Phase

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Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function

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Rad18 Regulates DNA Polymerase κ and Is Required for Recovery from S-Phase Checkpoint-Mediated Arrest

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Mammalian TIMELESS and Tipin are Evolutionarily Conserved Replication Fork-associated Factors

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Human Tim/Timeless-interacting Protein, Tipin, Is Required for Efficient Progression of S Phase and DNA Replication Checkpoint

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Postreplication Repair and PCNA Modification inSchizosaccharomyces pombe

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Lysine 63-Polyubiquitination Guards against Translesion Synthesis–Induced Mutations

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Mrc1 Is Required for Sister Chromatid Cohesion To Aid in Recombination Repair of Spontaneous Damage

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Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities

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Chk1-Dependent S-M Checkpoint Delay in Vertebrate Cells Is Linked to Maintenance of Viable Replication Structures

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Repeated Phosphopeptide Motifs in Human Claspin Are Phosphorylated by Chk1 and Mediate Claspin Function

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Chk1 is required to maintain Claspin stability

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A human DNA polymerase η complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin‐bound fraction of cells undergoing replication fork arrest

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Regulation of Claspin degradation by the ubiquitin‐proteosome pathway during the cell cycle and in response to ATR‐dependent checkpoint activation

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DNA-Damage Control: Claspin Destruction Turns off the Checkpoint

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Linking PCNA-dependent replication and ATR by human Claspin

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Y-family DNA polymerases and their role in tolerance of cellular DNA damage

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Regulation of PCNA–protein interactions for genome stability

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Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

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Checkpoint kinase 1 in DNA damage response and cell cycle regulation

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Ubiquitin signalling in DNA replication and repair

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Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

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Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response

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DNA damage tolerance: when it's OK to make mistakes

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DNA damage tolerance: a double-edged sword guarding the genome.

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Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway

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Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells

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Regulating post-translational modifications of the eukaryotic replication clamp PCNA

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Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

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FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres

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Y-family DNA polymerases in mammalian cells

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PCNA Modifications for Regulation of Post-Replication Repair Pathways

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Spartan/C1orf124, a Reader of PCNA Ubiquitylation and a Regulator of UV-Induced DNA Damage Response

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USP7 counteracts SCFβTrCP- but not APCCdh1-mediated proteolysis of Claspin

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Synthetically Lethal Interactions of ATM, ATR, and DNA-PKcs

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Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance

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Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer

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The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication

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Mechanisms of DNA Damage Tolerance: Post-Translational Regulation of PCNA

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Tim–Tipin dysfunction creates an indispensible reliance on the ATR–Chk1 pathway for continued DNA synthesis

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A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks

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ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells

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Roles of sequential ubiquitination of PCNA in DNA‐damage tolerance

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CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo

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ATR signaling at a glance

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A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers

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The fork and the kinase: A DNA replication tale from a CHK1 perspective

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USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation

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Bocavirus Infection Induces a DNA Damage Response That Facilitates Viral DNA Replication and Mediates Cell Death

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Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies

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Regulation of DNA damage tolerance in mammalian cells by post-translational modifications of PCNA

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Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction

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Historical perspective on the DNA damage response

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The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation

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A Timeless Link Between Circadian Patterns and Disease

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Ubiquitination of PCNA and Its Essential Role in Eukaryotic Translesion Synthesis

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The human intra-S checkpoint response to UVC-induced DNA damage

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Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA

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Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells

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Ataxin-3 promotes genome integrity by stabilizing Chk1

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Checkpoint responses to unusual structures formed by DNA repeats

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DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response

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The Breast Cancer Susceptibility Gene BRCA2 Is Required for the Maintenance of Telomere Homeostasis

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BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade

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Efficient Herpes Simplex Virus 1 Replication Requires Cellular ATR Pathway Proteins

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SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination

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Claspin functions in cell homeostasis—A link to cancer?

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CRL Ubiquitin Ligases and DNA Damage Response

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Translesion Synthesis or Repair by Specialized DNA Polymerases Limits Excessive Genomic Instability upon Replication Stress

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Ubiquitin‐family modifications in the replication of DNA damage

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ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus

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Dual functions of DNA replication forks in checkpoint signaling and PCNA ubiquitination

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Regulation of p53 by ING family members in suppression of tumor initiation and progression

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Regulation of translesion DNA synthesis in mammalian cells

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Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability

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DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target

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The Regulation of DNA Damage Tolerance by Ubiquitin and Ubiquitin-Like Modifiers

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