PreprintCited by 111DNA Repair MechanismsUbiquitin and proteasome pathwaysGenomics and Chromatin Dynamics

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Chk1 and Claspin potentiate PCNA ubiquitination

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Yang, Xiaohong H., Shiotani, Bunsyo, Classon, Marie, Zou, Lee·2008·Genes & Development

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Abstract

Chk1 is a kinase crucial for genomic integrity and an effector of ATR (ATM and Rad3-realated) in DNA damage response. Here, we show that Chk1 regulates the DNA damage-induced ubiquitination of proliferating cell nuclear antigen (PCNA), which facilitates the continuous replication of damaged DNA. Surprisingly, this Chk1 function requires the DNA replication protein Claspin but not ATR. Claspin, which is stabilized by Chk1, regulates the binding of the ubiquitin ligase Rad18 to chromatin. Timeless, a Claspin-associating protein, is also required for efficient PCNA ubiquitination. Thus, Chk1 and the Claspin–Timeless module of replication forks not only participate in ATR signaling, but also protect stressed forks independently of ATR.

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Authors: Yang, X. H., Shiotani, B., Classon, M., & Zou, L.
Affiliations: Harvard University (US)
ORCID: Yang, Xiaohong H.
Shiotani, Bunsyo
Classon, Marie
Zou, Lee
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2008-05-01
Volume: 22
Issue: 9
Pages: 1147-1152
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1632808
PMC: PMC2335311
OpenAlex: W2156915836
Cited by: 111
References: 35
Citations by year: 2025: 2 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 15 · 2012: 11
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Susan G. Komen for the Cure
Breast Cancer Alliance
National Institutes of Health
National Institute of General Medical Sciences (R01GM076388, GM076388)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: Chk1, Claspin, PCNA ubiquitination, ATR signaling, DNA damage response, TIMELESS, replication fork, replication stress, genome stability
MeSH terms: Checkpoint Kinase 1, DNA Replication, HeLa Cells, Humans, Hydroxyurea, Morpholines, Plasmids, Protein Kinases, Pyrones, Transfection, Ultraviolet Rays, Blotting, Western, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Proliferating Cell Nuclear Antigen, RNA, Small Interfering, Cell Line, Tumor, Adaptor Proteins, Signal Transducing, Ubiquitination, Ataxia Telangiectasia Mutated Proteins

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Chk1 and Claspin potentiate PCNA ubiquitination

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