Cited by 629Digestive system and related healthWnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

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The intestinal stem cell

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Barker, Nick, van de Wetering, Marc, Clevers, Hans·2008·Genes & Development

DOI 10.1101/gad.1674008PMC PMC2735277

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Abstract

The epithelium of the adult mammalian intestine is in a constant dialog with its underlying mesenchyme to direct progenitor proliferation, lineage commitment, terminal differentiation, and, ultimately, cell death. The epithelium is shaped into spatially distinct compartments that are dedicated to each of these events. While the intestinal epithelium represents the most vigorously renewing adult tissue in mammals, the stem cells that fuel this self-renewal process have been identified only recently. The unique epithelial anatomy makes the intestinal crypt one of the most accessible models for the study of adult stem cell biology. This review attempts to provide a comprehensive overview of four decades of research on crypt stem cells.

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Authors: Barker, N., van de Wetering, M., & Clevers, H.
Affiliations: University Medical Center Utrecht (NL)
ORCID: Barker, Nick
Clevers, Hans
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2008-07-15
Volume: 22
Issue: 14
Pages: 1856-1864
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1674008
PMC: PMC2735277
OpenAlex: W2132780101
Cited by: 629
References: 78
Citations by year: 2026: 14 · 2025: 13 · 2024: 25 · 2023: 33 · 2022: 19 · 2021: 33 · 2020: 27 · 2019: 29 · 2018: 41 · 2017: 44 · 2016: 36 · 2015: 26 · 2014: 47 · 2013: 40 · 2012: 34
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Digestive system and related health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: intestinal stem cells, intestinal epithelium, crypt, epithelial-mesenchymal interactions, lineage commitment, cell differentiation, cell death, progenitor cell proliferation
MeSH terms: Animals, Humans, Intestinal Mucosa, Intestines, Stem Cells, Signal Transduction

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