Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069

The FGF family: biology, pathophysiology and therapy

Beenken, A., & Mohammadi, M. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2792 · Cited by 1,945

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,865

Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting

Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6223 · Cited by 1,649

Nutritional Regulation of the Insulin-Like Growth Factors*

Thissen, J., Ketelslegers, J., & Underwood, L. E. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-1-80 · Cited by 1,575

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504

Regulation of FGF signaling: Recent insights from studying positive and negative modulators

Korsensky, L., & Ron, D. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.01.023 · Cited by 39

The Emerging Role of the FGF/FGFR Pathway in Gastrointestinal Stromal Tumor

Astolfi, A., Pantaleo, M. A., Indio, V., Urbini, M., & Nannini, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093313 · Cited by 38

The Potential Roles of Post-Translational Modifications of PPARγ in Treating Diabetes

Ji, X., Zhang, W., Yin, L., Shi, Z., Luan, J., Chen, L., & Liu, L. (2022) · Biomolecules · doi:10.3390/biom12121832 · Cited by 40

Perturbations of Fibroblast Growth Factors 19 and 21 in Type 2 Diabetes

Roesch, S. L., Styer, A. M., Wood, G. C., Kosak, Z., Seiler, J. L., Benotti, P. N., Petrick, A. T., Gabrielsen, J. D., Strodel, W. E., Gerhard, G. S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116928 · Cited by 36

Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation

Wu, W., Tsuchida, H., Kato, T., Niwa, H., Horikawa, Y., Takeda, J., & Iizuka, K. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.04.092 · Cited by 38

Fibroblast growth factor 21 is an early predictor of acute‐on‐chronic liver failure in critically ill patients with cirrhosis

Ruiz‐Margáin, A., Pohlmann, A., Ryan, P. B., Schierwagen, R., Chi‐Cervera, L. A., Jansen, C., Méndez-Guerrero, O., Flores-García, N. C., Lehmann, J., Torre, A., et al. (2018) · Liver Transplantation · doi:10.1002/lt.25041 · Cited by 37

Hepatic posttranscriptional network comprised of CCR4–NOT deadenylase and FGF21 maintains systemic metabolic homeostasis

Morita, M., Siddiqui, N., Katsumura, S., Rouya, C., Larsson, O. S., Nagashima, T., Hekmatnejad, B., Takahashi, A., Kiyonari, H., Zang, M., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816023116 · Cited by 37

Deficiency of fibroblast growth factor 21 aggravates obesity-induced atrophic responses in skeletal muscle

Kim, C.-S., Joe, Y., Choi, H., Back, S. H., Park, J. W., Chung, H., Roh, E., Kim, M., Ha, T. Y., & Yu, R. (2019) · Journal of Inflammation · doi:10.1186/s12950-019-0221-3 · Cited by 36

Dietary supplementation with tributyrin prevented weaned pigs from growth retardation and lethal infection via modulation of inflammatory cytokines production, ileal FGF19 expression, and intestinal acetate fermentation1

Gu, Y., Song, Y., Yin, H., Lin, S., Zhang, X., Che, L., Lin, Y., Xu, S., Feng, B., Wu, D., et al. (2017) · Journal of Animal Science · doi:10.2527/jas.2016.0911 · Cited by 41

Fibroblast growth factor 21: An emerging pleiotropic regulator of lipid metabolism and the metabolic network

Li, S., Zou, T., Chen, J., Li, J., & You, J. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.06.033 · Cited by 37

Regulating bile acids signaling for NAFLD: molecular insights and novel therapeutic interventions

Wei, M., Tu, W., & Huang, G. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1341938 · Cited by 39

Inhibition of fibroblast growth factor receptor 2 attenuates proliferation and invasion of pancreatic cancer

Matsuda, Y., Yoshimura, H., Suzuki, T., Uchida, E., Naito, Z., & Ishiwata, T. (2014) · Cancer Science · doi:10.1111/cas.12470 · Cited by 36

Transcriptional Regulation of Fibroblast Growth Factor 21 Expression

Bae, K.-H., Kim, J., & Park, K. (2014) · Endocrinology and Metabolism · doi:10.3803/enm.2014.29.2.105 · Cited by 37

Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state

Guan, D., Zhao, L., Chen, D., Yu, B., & Yu, J. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0821-0 · Cited by 36

Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice

Zhang, Y., Shaikh, N., Ferey, J. L. A., Wankhade, U. D., Chintapalli, S. V., Higgins, C. B., Crowley, J. R., Heitmeier, M. R., Stothard, A. I., Mihi, B., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.11.295 · Cited by 36

Targeting fibroblast growth factor 19 in liver disease: a potential biomarker and therapeutic target

Liu, W., Xie, D.-M., Zhu, G., Huang, G., Lin, Y.-Q., Wang, L., Shi, K., Hu, B., Braddock, M., Chen, Y., et al. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.997711 · Cited by 38

Cardiac Energy Dependence on Glucose Increases Metabolites Related to Glutathione and Activates Metabolic Genes Controlled by Mechanistic Target of Rapamycin

Schisler, J. C., Grevengoed, T. J., Pascual, F. L., Cooper, D. E., Ellis, J. M., Paul, D. S., Willis, M. S., Patterson, C., Jia, W. P., & Coleman, R. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.114.001136 · Cited by 36

Reactive Oxygen and Nitrogen Species (RONS) and Cytokines—Myokines Involved in Glucose Uptake and Insulin Resistance in Skeletal Muscle

Llanos, P., & Palomero, J. (2022) · Cells · doi:10.3390/cells11244008 · Cited by 39

Role of fibroblast growth factors in elicitation of cell responses

Laestander, C., & Engström, W. (2013) · Cell Proliferation · doi:10.1111/cpr.12084 · Cited by 35

The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling

Jager, J., Wang, F., Fang, B., Lim, H., Peed, L. C., Steger, D. J., Won, K., Kharitonenkov, A., Adams, A. C., & Lazar, M. A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.719120 · Cited by 35

Engineered fibroblast growth factor 19 protects from acetaminophen-induced liver injury and stimulates aged liver regeneration in mice

Álvarez‐Sola, G., Uriarte, I., Latasa, M. U., Jiménez, M., Bárcena‐Varela, M., Santamaría, E., Urtasun, R., Rodríguez‐Ortigosa, C. M., Prìeto, J., Corrales, F. J., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.480 · Cited by 35

Fibroblast Growth Factor 19: Potential modulation of hepatic metabolism for the treatment of non‐alcoholic fatty liver disease

Sciarrillo, C. M., Keirns, B. H., Koemel, N. A., Anderson, K. L., & Emerson, S. R. (2021) · Liver International · doi:10.1111/liv.14802 · Cited by 35

The Influence of Bariatric Surgery on Serum Bile Acids in Humans and Potential Metabolic and Hormonal Implications: a Systematic Review

Cole, A. J., Teigen, L. M., Jahansouz, C., Earthman, C. P., & Sibley, S. D. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0171-x · Cited by 34

Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis

de Haan, L. R., van der Lely, S. J., Warps, A. K., Hofsink, Q., Olthof, P. B., de Keijzer, M. J., Lionarons, D. A., Dias, L. M., Bruinsma, B. G., Uygun, K., et al. (2018) · Journal of Clinical and Translational Research · doi:10.18053/jctres.04.201801.001 · Cited by 33

FGF21 increases water intake, urine output and blood pressure in rats

Turner, T., Chen, X., Zahner, M. R., Opsahl, A., DeMarco, G. J., Boucher, M., Goodwin, B. J., & Perreault, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202182 · Cited by 33

Bone marrow mesenchymal stem cells: Fat on and blast off by FGF21

Wan, Y. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.12.014 · Cited by 34

Modulation of energy balance by fibroblast growth factor 21

Ramos, D. C., & Aguilar-Salinas, C. A. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0023 · Cited by 36

Hepatic FGF21: Its Emerging Role in Inter-Organ Crosstalk and Cancers

Sui, Y., & Chen, J. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.76924 · Cited by 33

Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis

Chen, X., Ward, S. C., Cederbaum, A. I., Xiong, H., & Lu, Y. (2017) · Toxicology · doi:10.1016/j.tox.2017.01.016 · Cited by 33

Cholestyramine treatment of healthy humans rapidly induces transient hypertriglyceridemia when treatment is initiated

Sjöberg, B. G., Straniero, S., Angelin, B., & Rudling, M. J. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00416.2016 · Cited by 32

Inducible Loss of the Aryl Hydrocarbon Receptor Activates Perigonadal White Fat Respiration and Brown Fat Thermogenesis via Fibroblast Growth Factor 21

Girer, N. G., Carter, D., Bhattarai, N., Mustafa, M. G., Denner, L. A., Porter, C. C., & Elferink, C. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040950 · Cited by 31

Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4

Alonge, K. M., Meares, G. P., & Hillgartner, F. B. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.762922 · Cited by 32

Acute caloric restriction counteracts hepatic bile acid and cholesterol deficiency in morbid obesity

Straniero, S., Rosqvist, F., Edholm, D., Ahlström, H. K., Kullberg, J., Sundbom, M., Risérus, U., & Rudling, M. J. (2017) · Journal of Internal Medicine · doi:10.1111/joim.12599 · Cited by 33

Pregnane X receptor (PXR) deficiency improves high fat diet-induced obesity via induction of fibroblast growth factor 15 (FGF15) expression

Zhao, L., Xu, J., Shi, Z., Englert, N. A., & Zhang, S. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.07.019 · Cited by 32

In vivo studies of glucagon secretion by human islets transplanted in mice

Tellez, K., Hang, Y., Gu, X., Chang, C., Stein, R. W., & Kim, S. K. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0213-x · Cited by 28

Mechanistic insight into nuclear receptor‐mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract (GSPE)

Downing, L. E., Edgar, D., Ellison, P. A., & Ricketts, M. (2017) · Cell Biochemistry and Function · doi:10.1002/cbf.3247 · Cited by 30

TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose

Zhang, Y., Higgins, C. B., Mayer, A. L., Mysorekar, I. U., Razani, B., Graham, M. J., Hruz, P. W., & DeBosch, B. J. (2018) · Autophagy · doi:10.1080/15548627.2018.1493044 · Cited by 30

Effects of supplemented isoenergetic diets varying in cereal fiber and protein content on the bile acid metabolic signature and relation to insulin resistance

Weickert, M. O., Hattersley, J. G., Kyrou, I., Arafat, A. M., Rudovich, N., Roden, M., Nowotny, P., von Loeffelholz, C., Matysik, S., Schmitz, G., et al. (2018) · Nutrition & Diabetes · doi:10.1038/s41387-018-0020-6 · Cited by 29

Effect of anthocyanins on metabolic syndrome through interacting with gut microbiota

Du, L., Ding, X., Tian, Y., Chen, J., & Li, W. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107511 · Cited by 33

Fibroblast growth factor 19 is correlated with an unfavorable prognosis and promotes progression by activating fibroblast growth factor receptor 4 in advanced-stage serous ovarian cancer

Hu, L., & CONG, L.-X. (2015) · Oncology Reports · doi:10.3892/or.2015.4212 · Cited by 30

Curtailing FGF19’s mitogenicity by suppressing its receptor dimerization ability

Niu, J., Zhao, J., Wu, J., Qiao, G., Gu, J., Zhou, C., Li, Q., Lei, Y., Wang, D., Lin, H., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2010984117 · Cited by 30

The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy

Deng, J., Liu, Y., Liu, Y., Li, W., & Nie, X. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s334996 · Cited by 28

Bile Acids in the Treatment of Cardiometabolic Diseases

Vı́tek, L. (2017) · Annals of Hepatology · doi:10.5604/01.3001.0010.5496 · Cited by 29

Metabolic Hormone FGF21 Is Induced in Ground Squirrels during Hibernation but Its Overexpression Is Not Sufficient to Cause Torpor

Nelson, B. T., Ding, X., Bonéy-Montoya, J., Gerard, R. D., Kliewer, S. A., & Andrews, M. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053574 · Cited by 28

FGF signaling: diverse roles during cochlear development

Ebeid, M., & Huh, S. (2017) · BMB Reports · doi:10.5483/bmbrep.2017.50.10.164 · Cited by 28

Gall bladder: The metabolic orchestrator

Li, Q., Tian, Y., & Chen, Y. (2019) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3140 · Cited by 28

Transcriptome profiling reveal Acanthopanax senticosus improves growth performance, immunity and antioxidant capacity by regulating lipid metabolism in GIFT (Oreochromis niloticus)

Li, H., Qiang, J., Song, C., & Xu, P. (2020) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2020.100784 · Cited by 28

Sex differences and aging: Is there a role of brown adipose tissue?

Hoffman, J. M., & Valencak, T. G. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111310 · Cited by 29

Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells

Pham, D. D., Bruelle, C., Thi, H., Pajanoja, C., Jin, C., Srinivasan, V., Olkkonen, V. M., Eriksson, O., Jauhiainen, M., Lalowski, M. M., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1758-z · Cited by 29

Serum fetuin‐B is positively associated with intrahepatic triglyceride content and increases the risk of insulin resistance in obese Chinese adults: A cross‐sectional study

Wang, D., Liu, Y., Liu, S., Lin, L., Liu, C., Shi, X., Chen, Z., Lin, M., Yang, S., Li, Z., et al. (2017) · Journal of Diabetes · doi:10.1111/1753-0407.12632 · Cited by 28

The total alkaloids of Berberidis Cortex alleviate type 2 diabetes mellitus by regulating gut microbiota, inflammation and liver gluconeogenesis

Tao, Y., Zeng, Y., Zeng, R., Gou, X., Zhou, X., Zhang, J., Nhamdriel, T., & Fan, G. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118957 · Cited by 26

Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism

Tassi, E., Garman, K. A., Schmidt, M. O., Ma, X., Kabbara, K. W., Üren, A., Tomita, Y. A., Goetz, R. M., Mohammadi, M., Wilcox, C. S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34238-5 · Cited by 28

Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Hormones of Energy Balance in a TCDD-Sensitive and a TCDD-Resistant Rat Strain

Lindén, J., Lensu, S., & Pohjanvirta, R. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150813938 · Cited by 25

Role of fibroblast growth factor 21 in gestational diabetes mellitus: A mini‐review

Yuan, D., Wu, B. J., Henry, A., Rye, K., & Ong, K. L. (2018) · Clinical Endocrinology · doi:10.1111/cen.13881 · Cited by 26

Selective FGFR/FGF pathway inhibitors: inhibition strategies, clinical activities, resistance mutations, and future directions

Repetto, M., Crimini, E., Giugliano, F., Morganti, S., Belli, C., & Curigliano, G. (2021) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2021.1947246 · Cited by 25

Methionine restriction alleviates diabetes-associated cognitive impairment via activation of FGF21

Zhang, Y., Wang, Y., Li, Y., Pang, J., Höhn, A., Dong, W., Gao, R. H., Liu, Y., Wang, D., She, Y., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103390 · Cited by 24

Gut microbiome of a porcine model of metabolic syndrome and HF-pEF

O’Donovan, A. N., Herisson, F. M., Fouhy, F., Ryan, P. M., Whelan, D., Johnson, C. N., Cluzel, G. L., Ross, R. P., Stanton, C., & Caplice, N. M. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00512.2019 · Cited by 24

Endocrine Fibroblast Growth Factors in Relation to Stress Signaling

Shimizu, M., & Sato, R. (2022) · Cells · doi:10.3390/cells11030505 · Cited by 25

Bile acid–gut microbiota crosstalk in irritable bowel syndrome

Gu, Y., Li, L., Yang, M., Liu, T., Song, X., Qin, X., Xu, X. J., Liu, J., Wang, B., & Cao, H. (2022) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2058353 · Cited by 26

Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver

Sarkar, A., Jin, Y., DeFelice, B. C., Logan, C. Y., Yang, Y., Anbarchian, T., Wu, P. V., Morri, M., Neff, N. F., Nguyen, H., et al. (2022) · eLife · doi:10.7554/elife.82311 · Cited by 23

Genetic variations of bile salt transporters

Kubitz, R., Dröge, C., Kluge, S., Stindt, J., & Häussinger, D. (2014) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2014.03.006 · Cited by 24

Fibroblast Growth Factor 21 (Fgf21) Gene Expression Is Elevated in the Liver of Mice Fed a High-Carbohydrate Liquid Diet and Attenuated by a Lipid Emulsion but Is Not Upregulated in the Liver of Mice Fed a High-Fat Obesogenic Diet

Hao, L., Huang, N. K., Ito, K., Sae‐tan, S., Lambert, J. D., & Ross, A. C. (2016) · Journal of Nutrition · doi:10.3945/jn.115.216572 · Cited by 24

MicroRNA-34a and Impaired FGF19/21 Signaling in Obesity

Fu, T., & Kemper, J. K. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2016.02.002 · Cited by 24

Antimicrobial promotion of pig growth is associated with tissue-specific remodeling of bile acid signature and signaling

Ipharraguerre, I. R., Pastor, J. J., Gavaldà‐Navarro, A., Villarroya, F., & Mereu, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-32107-9 · Cited by 26

Fibroblast growth factor 21 regulates glucose metabolism in part by reducing renal glucose reabsorption

Li, S., Wang, N., Guo, X., Li, J., Zhang, T., Ren, G., & Li, D. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.078 · Cited by 25

Bariatric Surgery: Prevalence, Predictors, and Mechanisms of Diabetes Remission

Argyropoulos, G. A. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0590-9 · Cited by 23

Fibroblast growth factor 19-targeted therapies for the treatment of metabolic disease

Rysz, J., Gluba-Brzózka, A., Mikhailidis, D. P., & Banach, M. (2015) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2015.1006357 · Cited by 23

Advances in Biological Functions and Clinical Studies of FGF21

Lin, W. J., Zhang, T., Zhou, Y., Zheng, J., & Lin, Z. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s317096 · Cited by 24

Exploring the role of a novel postbiotic bile acid: Interplay with gut microbiota, modulation of the farnesoid X receptor, and prospects for clinical translation

Wang, B., Han, D. W., Hu, X., Chen, J., Liu, Y., & Wu, J. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127865 · Cited by 24

Regulation of bile acid homeostasis by the intestinal Diet1–FGF15/19 axis

Reue, K., Lee, J. M., & Vergnes, L. (2014) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000060 · Cited by 23

Decreased placental and muscular expression of the fibroblast growth factor 19 in gestational diabetes mellitus

Wang, D., Xu, S., Ding, W., Zhu, C., Deng, S., Qiu, X., & Wang, Z. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12859 · Cited by 21

Fibroblast growth factor 21 is independently associated with severe hepatic steatosis in non‐obese HIV‐infected patients

Praktiknjo, M., Djayadi, N., Mohr, R. U., Schierwagen, R., Bischoff, J., Dold, L., Pohlmann, A., Schwarze‐Zander, C., Wasmuth, J., Boesecke, C., et al. (2019) · Liver International · doi:10.1111/liv.14107 · Cited by 22

The Enterokine Fibroblast Growth Factor 15/19 in Bile Acid Metabolism

Cariello, M., Piglionica, M., Gadaleta, R. M., & Moschetta, A. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_235 · Cited by 22

The role of FGF19 in metabolic regulation: insights from preclinical models to clinical trials

de Carvalho, M. B., Jorge, G. M. C. P., Zanardo, L. W., Hamada, L. M., Izabel, L. D. S., Santoro, S., & Magdalon, J. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00156.2024 · Cited by 23

Cholinergic signaling mediates the effects of xenin-25 on secretion of pancreatic polypeptide but not insulin or glucagon in humans with impaired glucose tolerance

Wang, S.-Y., Oestricker, L. Z., Wallendorf, M., Sterl, K., Dunai, J., Kilpatrick, C., Patterson, B., Reeds, D. N., & Wice, B. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192441 · Cited by 17

Leptin, Acting at Central Level, Increases FGF21 Expression in White Adipose Tissue via PPARβ/δ

Mazuecos, L., Pintado, C., Rubio, B., Guisantes-Batán, E., Andrés, A., & Gallardo, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094624 · Cited by 21

Antarctic krill oil ameliorates liver injury in rats exposed to alcohol by regulating bile acids metabolism and gut microbiota

Guo, P., Xue, M., Teng, X., Wang, Y., Ren, R., Han, J., Zhang, H., Tian, Y., & Liang, H. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109061 · Cited by 21

Exploring the Structural and Functional Diversity among FGF Signals: A Comparative Study of Human, Mouse, and Xenopus FGF Ligands in Embryonic Development and Cancer Pathogenesis

Goutam, R. S., Kumar, V., Lee, U., & Kim, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087556 · Cited by 20

Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs

Gędaj, A., Gregorczyk, P., Żukowska, D., Chorążewska, A., Ciura, K., Kalka, M., Porębska, N., & Opaliński, Ł. (2024) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2024.04.001 · Cited by 22

Hepatic FGF21 production is increased in late pregnancy in the mouse

Cui, Y., Giesy, S. L., Hassan, M., Davis, K., Zhao, S., & Boisclair, Y. R. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00554.2013 · Cited by 21

Valine Supplementation Does Not Reduce Lipid Accumulation and Improve Insulin Sensitivity in Mice Fed High-Fat Diet

Ma, Q., Hu, L., Zhu, J., Chen, J., Wang, Z., Yue, Z., Qiu, M., & Shan, A. (2020) · ACS Omega · doi:10.1021/acsomega.0c03707 · Cited by 21

Association of fibroblast growth factor 21 with alcohol consumption and alcohol liver cirrhosis

Wagner‐Skacel, J., Horvath, A., Grande, P., Wenninger, J., Matzer, F., Fazekas, C., Mörkl, S., Meinitzer, A., & Stadlbauer, V. (2020) · Neuropsychiatrie · doi:10.1007/s40211-020-00380-8 · Cited by 21

Fibroblast growth factor receptor signaling in metabolic dysfunction-associated fatty liver disease: Pathogenesis and therapeutic targets

Chu, Y., Yang, S., & Chen, X. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108844 · Cited by 21

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Smith, R. W., Duguay, A. N., Weiszmann, J., Stanislaus, S., Belouski, E., Cai, L., Yie, J., Xu, J., Gupte, J., Wu, X., et al. (2013) · BioDrugs · doi:10.1007/s40259-013-0013-x · Cited by 20

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Myronovych, A., Bhattacharjee, J., Salazar-Gonzalez, R.-M., Tan, B. K., Mowery, S., Ferguson, D. L., Ryan, K. K., Zhang, W., Zhao, X., Oehrle, M., et al. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00175.2020 · Cited by 20

Current understanding and controversies on the clinical implications of fibroblast growth factor 21

Badakhshi, Y., & Jin, T. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2020.1864278 · Cited by 20

Fibroblast growth factor 21: A new liver safeguard

Cariello, M., & Moschetta, A. (2014) · Hepatology · doi:10.1002/hep.27147 · Cited by 20

Effects of bile acid metabolism on intestinal health of livestock and poultry

Jia, H., & Dong, N. (2024) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13969 · Cited by 19

The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes

Higgins, C. B., Adams, J. A., Ward, M. H., Greenberg, Z. J., Milewska, M., Sun, J., Zhang, Y., Paracatu, L. C., Dong, Q., Ballentine, S. J., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102835 · Cited by 19

Mechanisms underlying the metabolic beneficial effect of curcumin intervention: Beyond anti-inflammation and anti-oxidative stress

Jin, T. (2018) · Obesity Medicine · doi:10.1016/j.obmed.2018.11.002 · Cited by 19

Fibroblast growth factors 19 and 21 in acute liver damage

Shan, Z., Álvarez‐Sola, G., Uriarte, I., Arechederra, M., Fernández‐Barrena, M. G., Berasain, C., Ju, C., & Avila, M. A. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.05.26 · Cited by 19

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Chen, S.-Y., Beretta, M., Alexopoulos, S. J., Shah, D. P., Olzomer, E. M., Hargett, S. R., Childress, E. S., Salamoun, J. M., Aleksovska, I., Roseblade, A., et al. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154724 · Cited by 19

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Rajeev, R., Seethalakshmi, P. S., Jena, P. K., Prathiviraj, R., Kiran, G. S., & Selvin, J. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1916429 · Cited by 18

Spatial distribution of beta‐klotho mRNA in the mouse hypothalamus, hippocampal region, subiculum, and amygdala

Bono, B. S. M., Ly, N. K. K., Miller, P. A., Williams-Ikhenoba, J. G., Dumiaty, Y., & Chee, M. J. S. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25306 · Cited by 19

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Wang, K., Chen, X., Ward, S. C., Liu, Y., Ouedraogo, Y., Xu, C. D., Cederbaum, A. I., & Lu, Y. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0037-x · Cited by 18

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Okubo, H., Kushiyama, A., Nakatsu, Y., Yamamotoya, T., Matsunaga, Y., Fujishiro, M., Sakoda, H., Ohno, H., Yoneda, M., & Asano, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103064 · Cited by 18

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Panezai, J., Altamash, M., Engström, P., & Larsson, A. O. (2020) · Journal of Diabetes Research · doi:10.1155/2020/6450742 · Cited by 20

Maternal exposure to phenanthrene during gestation disturbs glucose homeostasis in adult mouse offspring

Guo, J., Huang, J., Wang, Q., Fang, L., Zhang, S., Li, B., Lv, L., Chen, M., & Wang, C. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128635 · Cited by 17

Prenatal exposure of female mice to perfluorononanoic acid delays pubertal activation of the reproductive endocrine axis through enhanced hepatic FGF21 production

Zhang, Y., Xu, Y., Ding, H., Yu, W., & Chen, L. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128776 · Cited by 17

BMP2/Smad signaling pathway is involved in the inhibition function of fibroblast growth factor 21 on vascular calcification

Liu, X., Cao, F., Liu, S., Mi, Y., & Liu, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.098 · Cited by 17

Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state

Guan, D., Zhao, L., Chen, D., Yu, B., & Yu, J. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0821-0 · Cited by 36

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

Owen, B. M., Mangelsdorf, D. J., & Kliewer, S. A. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.10.002 · Cited by 286

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Fernandes-Freitas, I., & Owen, B. M. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.09.014 · Cited by 46

Minireview: Roles of Fibroblast Growth Factors 19 and 21 in Metabolic Regulation and Chronic Diseases

Zhang, F., Yu, L., Lin, X., Cheng, P., He, L., Li, X., Lu, X., Tan, Y., Yang, H., Cai, L., et al. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1155 · Cited by 130

Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver

Cicione, C., Degirolamo, C., & Moschetta, A. (2012) · Hepatology · doi:10.1002/hep.25929 · Cited by 95