Cited by 442Fibroblast Growth Factor ResearchGDF15 and Related BiomarkersParathyroid Disorders and Treatments

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Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

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Potthoff, Matthew J., Kliewer, Steven A., Mangelsdorf, David J.·2012·Genes & Development

DOI 10.1101/gad.184788.111PMC PMC3289879

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Abstract

We review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)—FGF15/19 and FGF21—that can function as hormones. Both FGF15/19 and FGF21 act on multiple tissues to coordinate carbohydrate and lipid metabolism in response to nutritional status. Whereas FGF15/19 is secreted from the small intestine in response to feeding and has insulin-like actions, FGF21 is secreted from the liver in response to extended fasting and has glucagon-like effects. FGF21 also acts in an autocrine fashion in several tissues, including adipose. The pharmacological actions of FGF15/19 and FGF21 make them attractive drug candidates for treating metabolic disease.

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Retracted
FGF-21 as a novel metabolic regulator
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Self-citation
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
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Self-citation
Klotho converts canonical FGF receptor into a specific receptor for FGF23
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Authors: Potthoff, M. J., Kliewer, S. A., & Mangelsdorf, D. J.
Affiliations: Howard Hughes Medical Institute (US)
The University of Texas Southwestern Medical Center (US)
ORCID: Potthoff, Matthew J.
Kliewer, Steven A.
Mangelsdorf, David J.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2012-02-02
Volume: 26
Issue: 4
Pages: 312-324
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.184788.111
PMC: PMC3289879
OpenAlex: W2099579483
Cited by: 442
References: 141
Citations by year: 2026: 19 · 2025: 13 · 2024: 30 · 2023: 16 · 2022: 37 · 2021: 30 · 2020: 29 · 2019: 27 · 2018: 39 · 2017: 41 · 2016: 28 · 2015: 36 · 2014: 46 · 2013: 37 · 2012: 12
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute (I-1558, I-1275)
Welch Foundation (I-1275, I-1558)
National Institutes of Health (I-1275, I-1558)
National Institute of General Medical Sciences (RL1GM084436)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK067158)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › GDF15 and Related Biomarkers
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Keywords: FGF15/19, FGF21, carbohydrate metabolism, lipid metabolism, nutritional status, fasting, insulin-like activity, autocrine signaling, adipose tissue, small intestine, liver
MeSH terms: Animals, Bile Acids and Salts, Fasting, Fibroblast Growth Factors, Homeostasis, Humans, Neoplasms

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Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

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