The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Emerging roles of the corepressors NCoR1 and SMRT in homeostasis
Open accessAbstract
Epigenetic regulation of gene expression is strongly influenced by the accessibility of nucleosomal DNA or the state of chromatin compaction. In this context, coregulators, including both coactivators and corepressors, are pivotal intermediates that bridge chromatin-modifying enzymes and transcription factors. NCoR1 (nuclear receptor corepressor) and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) are among the best-characterized corepressors from a molecular point of view. These coregulators have conserved orthologs in lower organisms, which underscores their functional importance. Here we summarize the results from recent in vivo studies that reveal the wide-ranging roles of NCoR1 and SMRT in developmental as well as homeostatic processes, including metabolism, inflammation, and circadian rhythms. We also discuss the potential implications of NCoR1 and SMRT regulation of pathways ranging from genomic stability and carcinogenesis to metabolic diseases such as type 2 diabetes.
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“In fact, PGC-1α and NCoR1 oppositely regulate several transcription factors, including nuclear respiratory factors, estrogen-related receptors and PPARs (Scarpulla, 2011; Andreux et al, 2013; Mottis et al, 2013).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Mottis et al, 2013
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Cites
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Milazzo, G., Mercatelli, D., Muzio, G. D., Triboli, L., Rosa, P. D., Perini, G., & Giorgi, F. M. (2020) · Genes · doi:10.3390/genes11050556 · Cited by 448
Muscle as a “Mediator” of Systemic Metabolism
Baskin, K. K., Winders, B. R., & Olson, E. N. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.021 · Cited by 333
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Nacev, B. A., Sanchez-Vega, F., Smith, S. A., Antonescu, C. R., Rosenbaum, E., Shi, H., Tang, C., Socci, N. D., Rana, S., Gularte-Mérida, R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30453-x · Cited by 232
Metadata
- Authors
- Mottis, A., Mouchiroud, L., & Auwerx, J.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-04-15
- Volume
- 27
- Issue
- 8
- Pages
- 819-835
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC3650221
- OpenAlex
- W2139472488
- Cited by
- 297
- References
- 117
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 18 · 2023: 29 · 2022: 34 · 2021: 34 · 2020: 29 · 2019: 28 · 2018: 17 · 2017: 22 · 2016: 18 · 2015: 19 · 2014: 17 · 2013: 4
- Type
- posted content
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- Locations
- Genes & Development (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Science Foundation (310030)
- Velux Stiftung
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (136201, 31003A, 143748, 124713, 310030)
- National Institutes of Health
- National Institute on Aging (R01AG043930)
- National Heart, Lung, and Blood Institute (R01HL106511-01A, R01HL106511)
- FP7 Ideas: European Research Council (231138)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- NCOR1, SMRT, nuclear receptor corepressor, corepressors, epigenetic regulation, chromatin condensation, transcriptional co-regulation, homeostasis, metabolism, inflammation, circadian rhythm, genome stability, carcinogenesis, type 2 diabetes
- MeSH terms
- Animals, Gene Expression Regulation, Homeostasis, Humans, Nuclear Receptor Co-Repressor 1, Nuclear Receptor Co-Repressor 2
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