Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

mTOR Signaling in Growth Control and Disease

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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

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Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

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Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

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A transcriptional co-repressor that interacts with nuclear hormone receptors

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A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ

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Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase

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A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

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HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

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Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

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Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

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Enzymatic Activity Associated with Class II HDACs Is Dependent on a Multiprotein Complex Containing HDAC3 and SMRT/N-CoR

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Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways

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A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism

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mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

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The SMRT and N-CoR Corepressors Are Activating Cofactors for Histone Deacetylase 3

Guenther, M. G., Barak, O., & Lazar, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.18.6091-6101.2001 · Cited by 611

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.

Baek, S. H., Ohgi, K., Rose, D., Koo, E., Glass, C., & Rosenfeld, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00809-7 · Cited by 591

A Corepressor/Coactivator Exchange Complex Required for Transcriptional Activation by Nuclear Receptors and Other Regulated Transcription Factors

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Transcriptional Repression of Atherogenic Inflammation: Modulation by PPARδ

Lee, C., Chawla, A., Urbiztondo, N., Liao, D., Boisvert, W. A., & Evans, R. M. (2003) · Science · doi:10.1126/science.1087344 · Cited by 580

A histone deacetylase corepressor complex regulates the Notch signal transduction pathwayPreprint

Kao, H., Ordentlich, P., Koyano‐Nakagawa, N., Tang, Z., Downes, M., Kintner, C. R., Evans, R. M., & Kadesch, T. R. (1998) · Genes & Development · doi:10.1101/gad.12.15.2269 · Cited by 579

Parallel SUMOylation-Dependent Pathways Mediate Gene- and Signal-Specific Transrepression by LXRs and PPARγ

Ghisletti, S., Huang, W., Ogawa, S., Pascual, G., Lin, M.-E., Willson, T. M., Rosenfeld, M. G., & Glass, C. K. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.11.022 · Cited by 561

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

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Deconstructing repression: evolving models of co-repressor action

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Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development

Jepsen, K., Hermanson, O., Onami, T. M., Gleiberman, A. S., Lunyak, V. V., McEvilly, R. J., Kurokawa, R., Kumar, V., Liu, F. C., Seto, E., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00064-7 · Cited by 511

Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate

Watson, P. J., Fairall, L., Santos, G. M., & Schwabe, J. W. R. (2012) · Nature · doi:10.1038/nature10728 · Cited by 505 · cited 5×

Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repressionPreprint

Kao, H., Downes, M., Ordentlich, P., & Evans, R. M. (2000) · Genes & Development · doi:10.1101/gad.14.1.55 · Cited by 424

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

Jepsen, K., Solum, D., Zhou, T., McEvilly, R. J., Kim, H., Glass, C. K., Hermanson, O., & Rosenfeld, M. G. (2007) · Nature · doi:10.1038/nature06270 · Cited by 407

Drosophila Genome-wide Obesity Screen Reveals Hedgehog as a Determinant of Brown versus White Adipose Cell Fate

Pospisilik, J. A., Schramek, D., Schnidar, H., Cronin, S. J. F., Nehme, N. T., Zhang, X., Knauf, C., Cani, P. D., Aumayr, K., Todoric, J., et al. (2010) · Cell · doi:10.1016/j.cell.2009.12.027 · Cited by 374

OPERating ON Chromatin, a Colorful Language where Context Matters

Gardner, K. E., Allis, C. D., & Strahl, B. D. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.01.040 · Cited by 373

Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control

Bhaskara, S., Chyla, B., Amann, J. M., Knutson, S. K., Cortez, D., Sun, Z., & Hiebert, S. W. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.030 · Cited by 369

Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

Montgomery, R. L., Potthoff, M. J., Haberland, M., Qi, X., Matsuzaki, S., Humphries, K. M., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35847 · Cited by 365

Hdac3 is essential for the maintenance of chromatin structure and genome stability

Bhaskara, S., Knutson, S. K., Jiang, G., Chandrasekharan, M. B., Wilson, A. J., Zheng, S., Yenamandra, A., Locke, K., Yuan, J.-L., Bonine-Summers, A. R., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.10.022 · Cited by 353

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

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Sharp, an inducible cofactor that integrates nuclear receptor repression and activationPreprint

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Biological roles and mechanistic actions of co-repressor complexes

Jepsen, K., & Rosenfeld, M. G. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.4.689 · Cited by 322

N-CoR controls differentiation of neural stem cells into astrocytes

Hermanson, O., Jepsen, K., & Rosenfeld, M. G. (2002) · Nature · doi:10.1038/nature01156 · Cited by 308

Pioglitazone Induces In Vivo Adipocyte Differentiation in the Obese Zucker fa/fa Rat

Haliakon, S., Doaré, L., Foufelle, F., Kergoat, M., Guerre-Millo, M., Berthault, M., Dugail, I., Morin, J., Auwerx, J. H., & Ferré, P. (1997) · Diabetes · doi:10.2337/diab.46.9.1393 · Cited by 306

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy

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Transcriptional repression by nuclear hormone receptors.

Hu, X., & Lazar, M. (2000) · Trends in endocrinology and metabolism · doi:10.1016/s1043-2760(99)00215-5 · Cited by 297

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

Alenghat, T., Meyers, K. C., Mullican, S. E., Leitner, K., Adeniji‐Adele, A., Avila, J. L., Bućan, M., Ahima, R. S., Kaestner, K. H., & Lazar, M. A. (2008) · Nature · doi:10.1038/nature07541 · Cited by 295

The Orphan Nuclear Receptor Rev-erbα Recruits the N-CoR/Histone Deacetylase 3 Corepressor to Regulate the Circadian Bmal1 Gene

Yin, L., & Lazar, M. A. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0057 · Cited by 283

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limbPreprint

Vokes, S. A., Ji, H., Wong, W. H., & McMahon, A. P. (2008) · Genes & Development · doi:10.1101/gad.1693008 · Cited by 283

Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks

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NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

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The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program

Pijnappel, W. W. M. P., Schaft, D., Roguev, A., Shevchenko, A., Tekotte, H., Wilm, M., Rigaut, G., Séraphin, B., Aasland, R., & Stewart, A. F. (2001) · Genes & Development · doi:10.1101/gad.207401 · Cited by 265

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

Li, P., Fan, W., Xu, J., Lu, M. M., Yamamoto, H., Auwerx, J. H., Sears, D. D., Talukdar, S., Oh, D., Chen, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.050 · Cited by 264

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathwaysPreprint

Ghisletti, S., Huang, W. J. M., Jepsen, K., Benner, C. W., Hardiman, G., Rosenfeld, M. G., & Glass, C. K. (2009) · Genes & Development · doi:10.1101/gad.1773109 · Cited by 261

The Retinoblastoma-Histone Deacetylase 3 Complex Inhibits PPARγ and Adipocyte Differentiation

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PPARγ in human and mouse physiology

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HDAC3: taking the SMRT-N-CoRrect road to repression

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SMRT Derepression by the IκB Kinase α

Hoberg, J. E., Yeung, F., & Mayo, M. W. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.010 · Cited by 220

SMRTER, a Drosophila Nuclear Receptor Coregulator, Reveals that EcR-Mediated Repression Is Critical for Development

Tsai, C., Kao, H., Yao, T., McKeown, M., & Evans, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80365-2 · Cited by 218

The SMRT Corepressor Is Regulated by a MEK-1 Kinase Pathway: Inhibition of Corepressor Function Is Associated with SMRT Phosphorylation and Nuclear Export

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PPARδ-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis

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Regulation of Androgen Receptor Activity by the Nuclear Receptor Corepressor SMRT*

Liao, G., Chen, L.-Y., Zhang, A., Godavarthy, A., Xia, F., Ghosh, J. C., Li, H., & Chen, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206374200 · Cited by 207

The N-CoR/Histone Deacetylase 3 Complex Is Required for Repression by Thyroid Hormone Receptor

Ishizuka, T., & Lazar, M. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5122-5131.2003 · Cited by 202

Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo

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Unique forms of human and mouse nuclear receptor corepressor SMRT.

Ordentlich, P., Downes, M., Xie, W., Genin, A., Spinner, N., & Evans, R. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.6.2639 · Cited by 183

A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation

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Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery

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Nuclear hormone receptor co-repressors: Structure and function

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A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signalingPreprint

Ariyoshi, M., & Schwabe, J. W. R. (2003) · Genes & Development · doi:10.1101/gad.266203 · Cited by 163

Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR

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TBL1 and TBLR1 Phosphorylation on Regulated Gene Promoters Overcomes Dual CtBP and NCoR/SMRT Transcriptional Repression Checkpoints

Perissi, V., Scafoglio, C., Zhang, J., Ohgi, K. A., Rose, D. W., Glass, C. K., & Rosenfeld, M. G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.01.020 · Cited by 160

The Nuclear Receptor Corepressor (N-CoR) Contains Three Isoleucine Motifs (I/LXXII) That Serve as Receptor Interaction Domains (IDs)

Webb, P., Anderson, C. M., Valentine, C. D., Nguyen, P. T., Marimuthu, A., West, B. L., Baxter, J. D., & Kushner, P. J. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.12.0566 · Cited by 151

The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo

Astapova, I. I., Lee, L. J., Morales, C., Tauber, S., Bilban, M., & Hollenberg, A. N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804604105 · Cited by 149

Nuclear Receptor Rev-Erbα: A Heme Receptor that Coordinates Circadian Rhythm and Metabolism

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Nuclear IKK activity leads to dysregulated Notch-dependent gene expression in colorectal cancer

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Emerging roles of peroxisome proliferator-activated receptor-β/δ in inflammation

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SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor

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Transcriptional Repression by the SMRT-mSin3 Corepressor: Multiple Interactions, Multiple Mechanisms, and a Potential Role for TFIIB

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The corepressor N-CoR and its variants RIP13a and RIP13 1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70

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Active repression of RAR signaling is required for head formationPreprint

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The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor.

Yoon, H.-G., & Wong, J. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0324 · Cited by 120

Characterization of Receptor Interaction and Transcriptional Repression by the Corepressor SMRT

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The Bcl6-SMRT/NCoR Cistrome Represses Inflammation to Attenuate Atherosclerosis

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The Specificity of Interactions between Nuclear Hormone Receptors and Corepressors Is Mediated by Distinct Amino Acid Sequences within the Interacting Domains

Cohen, R., Brzostek, S. R., Kim, B. W., Chorev, M., Wondisford, F. E., & Hollenberg, A. N. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.7.0669 · Cited by 115

Transcriptional Integration of TLR2 and TLR4 Signaling at the NCoR Derepression Checkpoint

Huang, W. J. M., Ghisletti, S., Perissi, V., Rosenfeld, M. G., & Glass, C. K. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.05.023 · Cited by 109

Diet-induced Lethality Due to Deletion of the Hdac3 Gene in Heart and Skeletal Muscle

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SMRT and N-CoR Corepressors Are Regulated by Distinct Kinase Signaling Pathways*

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Cooperative regulation in development by SMRT and FOXP1Preprint

Jepsen, K., Gleiberman, A. S., Shi, C., Simon, D. I., & Rosenfeld, M. G. (2008) · Genes & Development · doi:10.1101/gad.1637108 · Cited by 95

SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis

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Integrative Genomics Identifies the Corepressor SMRT as a Gatekeeper of Adipogenesis through the Transcription Factors C/EBPβ and KAISO

Raghav, S. K., Waszak, S. M., Krier, I., Gubelmann, C., Isakova, A., Mikkelsen, T. S., & Deplancke, B. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.03.017 · Cited by 92

The Nuclear Receptor Corepressor (NCoR) Controls Thyroid Hormone Sensitivity and the Set Point of the Hypothalamic-Pituitary-Thyroid Axis

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S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver

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Aberrant Cytoplasmic Localization of N-CoR in Colorectal Tumors

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Adipocyte NCoR Knockout Decreases PPARg Phosphorylation and Enhances PPARg Activity and Insulin Sensitivity

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CHAPTER 274 – Corepressors in Mediating Repression by Nuclear Receptors

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