PreprintCited by 299Genomics and Chromatin DynamicsEpigenetics and DNA MethylationNuclear Receptors and Signaling

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Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

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Mottis, Adrienne, Mouchiroud, Laurent, Auwerx, Johan·2013·Genes & Development

DOI 10.1101/gad.214023.113PMC PMC3650221

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Abstract

Epigenetic regulation of gene expression is strongly influenced by the accessibility of nucleosomal DNA or the state of chromatin compaction. In this context, coregulators, including both coactivators and corepressors, are pivotal intermediates that bridge chromatin-modifying enzymes and transcription factors. NCoR1 (nuclear receptor corepressor) and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) are among the best-characterized corepressors from a molecular point of view. These coregulators have conserved orthologs in lower organisms, which underscores their functional importance. Here we summarize the results from recent in vivo studies that reveal the wide-ranging roles of NCoR1 and SMRT in developmental as well as homeostatic processes, including metabolism, inflammation, and circadian rhythms. We also discuss the potential implications of NCoR1 and SMRT regulation of pathways ranging from genomic stability and carcinogenesis to metabolic diseases such as type 2 diabetes.

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Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546
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St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J. M., Rhee, J., Jäger, S., Handschin, C., Zheng, K., Lin, J., Yang, W., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.024 · Cited by 2,233
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,072
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943
A transcriptional co-repressor that interacts with nuclear hormone receptors
Chen, J. D., & Evans, R. M. (1995) · Nature · doi:10.1038/377454a0 · Cited by 1,794
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
Pascual, G., Fong, A. L., Ogawa, S., Gamliel, A., Li, A. C., Perissi, V., Rose, D. W., Willson, T. M., Rosenfeld, M. G., & Glass, C. K. (2005) · Nature · doi:10.1038/nature03988 · Cited by 1,287
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Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R. J., Hassig, C. A., Ayer, D. E., Schreiber, S. L., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80218-4 · Cited by 1,230
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Show all 117 references

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Sinha, R. A., & Yen, P. M. (2014) · Cited by 44
Hyperthermia Selectively Destabilizes Oncogenic Fusion Proteins
Maimaitiyiming, Y., Wang, Q. Q., Yang, C., Ogra, Y., Lou, Y., Smith, C. A., Hussain, L., Shao, Y., Lin, J., Liu, J., et al. (2021) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-20-0188 · Cited by 41
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Korman, B. D., Marangoni, R. G., Lord, G., Olefsky, J. M., Tourtellotte, W. G., & Varga, J. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1630-z · Cited by 40
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Yu, L., Jearawiriyapaisarn, N., Lee, M. P., Hosoya, T., Wu, Q., Myers, G., Lim, K.-C., Kurita, R., Nakamura, Y., Vojtek, A. B., et al. (2018) · Genes & Development · doi:10.1101/gad.318436.118 · Cited by 40
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Ramatchandirin, B., Pearah, A., & He, L. (2023) · Life · doi:10.3390/life13020515 · Cited by 45
Nuclear factor-κB regulates the expression of multiple genes encoding liver transport proteins.
Balasubramaniyan, N., Ananthanarayanan, M., & Suchy, F. (2016) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00363.2015 · Cited by 37
Distinct role of nuclear receptor corepressor 1 regulated de novo fatty acids synthesis in liver regeneration and hepatocarcinogenesis in mice
Ouyang, Q., Lin, X., Zhu, Y., Zheng, B. J., Liang, L., Yang, Y., Hou, G., Chen, X., Luo, G., Huo, F., et al. (2017) · Hepatology · doi:10.1002/hep.29562 · Cited by 36
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Kang, Z., & Fan, R. (2020) · The FASEB Journal · doi:10.1096/fj.202000055rr · Cited by 42
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Müller, L., Hainberger, D., Stolz, V., & Ellmeier, W. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ri0418-168r · Cited by 38
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Mark, K. G., & Rapé, M. (2021) · EMBO Reports · doi:10.15252/embr.202051078 · Cited by 39
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Sauer, S. (2014) · ChemBioChem · doi:10.1002/cbic.201402124 · Cited by 35
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Luo, J., Chen, Z., Qiao, Y., Tien, J. C.-Y., Young, E., Mannan, R., Mahapatra, S., Bhattacharyya, R., Xiao, L., He, T., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02336-6 · Cited by 39
The 26S proteasome and initiation of gene transcription.
Durairaj, G., & Kaiser, P. (2014) · Biomolecules · doi:10.3390/biom4030827 · Cited by 34
Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm
Wu, Y., Lin, X., Lim, I. Y., Chen, L., Teh, A. L., MacIsaac, J. L., Tan, K. H., Kobor, M. S., Chong, Y. S., Gluckman, P. D., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-018-0599-4 · Cited by 33
Loss of autophagy impairs physiological steatosis by accumulation of NCoR1
Takahashi, S.-S., Sou, Y., Saito, T., Kuma, A., Yabe, T., Sugiura, Y., Lee, H., Suematsu, M., Yokomizo, T., Koike, M., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201900513 · Cited by 37
A structural mechanism of nuclear receptor biased agonism
Nemetchek, M. D., Chrisman, I. M., Rayl, M. L., Voss, A. H., & Hughes, T. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2215333119 · Cited by 33
Changes in chromatin accessibility landscape and histone H3 core acetylation during valproic acid-induced differentiation of embryonic stem cells
Baumann, C., Zhang, X., Zhu, L., Fan, Y., & Fuente, R. D. L. (2021) · Epigenetics & Chromatin · doi:10.1186/s13072-021-00432-5 · Cited by 33
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Gui, Z., Shi, W., Zhou, F., Yan, Y., Li, Y., & Xu, Y. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106632 · Cited by 34
Nuclear receptor corepressor 1 represses cardiac hypertrophy
Li, C., Sun, X., Chen, B., Zeng, M., Du, L., Liu, T., Gu, H., Liu, Y., Li, Y., Zhou, L., et al. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201809127 · Cited by 31
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Duan, Y., Zhang, L., Li, F., Guo, Q., Long, C., Yin, Y., Kong, X., Peng, M., & Wang, W. (2018) · Food & Function · doi:10.1039/c8fo00898a · Cited by 31
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Kumar, A. V., Dumasia, K., Deshpande, S., & Balasinor, N. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.02.017 · Cited by 30
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Kong, Y., Zhou, W., & Sun, Z. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0667-y · Cited by 29
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Lee, K., Whedon, S. D., Wang, Z. A., & Cole, P. A. (2022) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2022.102179 · Cited by 33
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Cui, W., Sun, M., Zhang, S., Shen, X., Galeva, N. A., Williams, T. D., & Staudinger, J. L. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.02.008 · Cited by 30
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Authors: Mottis, A., Mouchiroud, L., & Auwerx, J.
Affiliations: École Polytechnique Fédérale de Lausanne (CH)
ORCID: Mottis, Adrienne
Mouchiroud, Laurent
Auwerx, Johan
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2013-04-15
Volume: 27
Issue: 8
Pages: 819-835
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.214023.113
PMC: PMC3650221
OpenAlex: W2139472488
Cited by: 297
References: 117
Citations by year: 2026: 11 · 2025: 16 · 2024: 18 · 2023: 29 · 2022: 34 · 2021: 34 · 2020: 29 · 2019: 28 · 2018: 17 · 2017: 22 · 2016: 18 · 2015: 19 · 2014: 17 · 2013: 4
Type: posted content
Language: en
Open access: hybrid
doi.org
Licence: other-oa
Locations: Genes & Development (publishedVersion, other-oa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders: National Science Foundation (310030)
Velux Stiftung
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (136201, 31003A, 143748, 124713, 310030)
National Institutes of Health
National Institute on Aging (R01AG043930)
National Heart, Lung, and Blood Institute (R01HL106511-01A, R01HL106511)
FP7 Ideas: European Research Council (231138)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: NCOR1, SMRT, nuclear receptor corepressor, corepressors, epigenetic regulation, chromatin condensation, transcriptional co-regulation, homeostasis, metabolism, inflammation, circadian rhythm, genome stability, carcinogenesis, type 2 diabetes
MeSH terms: Animals, Gene Expression Regulation, Homeostasis, Humans, Nuclear Receptor Co-Repressor 1, Nuclear Receptor Co-Repressor 2

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Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

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