The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation
Open accessAbstract
N6-methyladenosine (m 6 A) is the most prevalent and internal modification that occurs in the messenger RNAs (mRNA) of most eukaryotes, although its functional relevance remained a mystery for decades. This modification is installed by the m 6 A methylation “writers” and can be reversed by demethylases that serve as “erasers.” In this review, we mainly summarize recent progress in the study of the m 6 A mRNA methylation machineries across eukaryotes and discuss their newly uncovered biological functions. The broad roles of m 6 A in regulating cell fates and embryonic development highlight the existence of another layer of epigenetic regulation at the RNA level, where mRNA is subjected to chemical modifications that affect protein expression.
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Cites
Functions of DNA methylation: islands, start sites, gene bodies and beyond
Jones, P. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3230 · Cited by 6,061
N6-methyladenosine-dependent regulation of messenger RNA stability
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Self-citationComprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
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“Whether and how WTAP regulates alternative splicing in an m6A-dependent manner have yet to be systematically explored. m6A erasers in mammals FTO is the first identified demethylase that oxidatively reverses m6A to adenosine inmRNA (Jia et al. 2011).”
InfluentialSelf-citationALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.015 · Cited by 3,550
Self-citationN6-methyladenosine Modulates Messenger RNA Translation Efficiency
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Self-citationTet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y. (2011) · Science · doi:10.1126/science.1210597 · Cited by 3,451
Self-citationDNA methylation landscapes: Provocative insights from epigenomics
Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039
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TET enzymes, TDG and the dynamics of DNA demethylation
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Cited by
Extensive translation of circular RNAs driven by N6-methyladenosine
Yang, Y., Fan, X., Mao, M., Song, X., Wu, P., Zhang, Y., Jin, Y., Yang, Y., Chen, L.-L., Wang, Y., et al. (2017) · Cell Research · doi:10.1038/cr.2017.31 · Cited by 1,855
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
Lin, S., Choe, J., Du, P., Triboulet, R., & Gregory, R. I. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.021 · Cited by 1,531
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
Cui, Q., Shi, H., Ye, P., Li, L., Qu, Q., Sun, G., Sun, G., Lu, Z., Huang, Y., Yang, C.-G., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.059 · Cited by 1,252
Self-citationThe U6 snRNA m 6 A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention
Pendleton, K. E., Chen, B., Liu, K., Hunter, O. V., Xie, Y., Tu, B. P., & Conrad, N. K. (2017) · Cell · doi:10.1016/j.cell.2017.05.003 · Cited by 1,085
The role of m6A RNA methylation in cancer
Sun, T., Wu, R., & Ming, L. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108613 · Cited by 963
Metadata
- Authors
- Yue, Y., Liu, J., & He, C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-07-01
- Volume
- 29
- Issue
- 13
- Pages
- 1343-1355
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2201760124
- Cited by
- 922
- References
- 12
- Type
- posted content
- Language
- en
- Open access
- diamond
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