The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.
Open accessAbstract
Rapid degradation of c-fos proto-oncogene mRNA is crucial for transient c-fos gene expression. Experiments were performed to investigate the cellular mechanisms responsible for the extremely short half-life of human c-fos mRNA in growth-factor-stimulated fibroblasts. These experiments demonstrate the existence of two distinct cellular pathways for rapid c-fos mRNA degradation. Each of these pathways recognizes a different, functionally independent instability determinant within the c-fos transcript. One instability determinant, which is located within the c-fos 3'-untranslated region, is a 75-nucleotide AU-rich segment. Insertion of this element into beta-globin mRNA markedly reduces the half-life of that normally long-lived message. Nevertheless, specific deletion of the AU-rich element from c-fos mRNA has little effect on the transcript's cytoplasmic half-life due to the presence of the other c-fos instability determinant, which is located in the protein-coding segment of the c-fos message. Examination of mRNA decay in cells treated with transcription inhibitors indicates that one c-fos mRNA degradation pathway is dependent on RNA synthesis, whereas the other is not.
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Cites
Shaw, G., & Kamen, R. (1986) · Cell · doi:10.1016/0092-8674(86)90341-7 · Cited by 4,012
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
Greenberg, M. E., & Ziff, E. B. (1984) · Nature · doi:10.1038/311433a0 · Cited by 3,064
Self-citationInduction of c-fos gene and protein by growth factors precedes activation of c-myc
Müller, R., Bravo, R., Burckhardt, J., & Curran, T. (1984) · Nature · doi:10.1038/312716a0 · Cited by 1,369
The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes
Chiu, R., Boyle, W. J., Meek, J., Smeal, T., Hunter, T., & Karin, M. (1988) · Cell · doi:10.1016/0092-8674(88)90076-1 · Cited by 1,335
At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells
Kozak, M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90418-9 · Cited by 1,182
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein
Kruijer, W., Cooper, J. A., Hunter, T., & Verma, I. M. (1984) · Nature · doi:10.1038/312711a0 · Cited by 916
Greenberg, M. E., Greene, L. A., & Ziff, E. B. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38689-1 · Cited by 875
Self-citationTreisman, R. (1985) · Cell · doi:10.1016/0092-8674(85)90285-5 · Cited by 816
Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription
Greenberg, M. E., Ziff, E. B., & Greene, L. A. (1986) · Science · doi:10.1126/science.3749894 · Cited by 755
Self-citationFos-Associated Protein p39 Is the Product of the jun Proto-Oncogene
Rauscher, F. J., Cohen, D. R., Curran, T., Bos, T. J., Vogt, P. K., Bohmann, D., Tjian, R., & Franza, B. R. (1988) · Science · doi:10.1126/science.3130660 · Cited by 629
Cited by
mRNA stability in mammalian cells
Ross, J. (1995) · Microbiological Reviews · doi:10.1128/mr.59.3.423-450.1995 · Cited by 1,411
Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin
Carballo, E., Lai, W. S., & Blackshear, P. J. (1998) · Science · doi:10.1126/science.281.5379.1001 · Cited by 1,161
Brennan, C. M., & Steitz*, J. A. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000854 · Cited by 1,095
AU-rich elements and associated factors: are there unifying principles?
Barreau, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki1012 · Cited by 907
Fan, X. C., & Steitz, J. A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3448 · Cited by 866
Metadata
- Authors
- Shyu, A. B., Greenberg, M. E., & Belasco, J. G.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1989-01
- Volume
- 3
- Issue
- 1
- Pages
- 60-72
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2001748566
- Cited by
- 586
- References
- 32
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Shyu, A. B., Greenberg, M. E., & Belasco, J. G. (1989). The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes & Development. https://doi.org/10.1101/gad.3.1.60
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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