The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin
Abstract
Tumor necrosis factor–α (TNF-α) is a major mediator of both acute and chronic inflammatory responses in many diseases. Tristetraprolin (TTP), the prototype of a class of Cys-Cys-Cys-His (CCCH) zinc finger proteins, inhibited TNF-α production from macrophages by destabilizing its messenger RNA. This effect appeared to result from direct TTP binding to the AU-rich element of the TNF-α messenger RNA. TTP is a cytosolic protein in these cells, and its biosynthesis was induced by the same agents that stimulate TNF-α production, including TNF-α itself. These findings identify TTP as a component of a negative feedback loop that interferes with TNF-α production by destabilizing its messenger RNA. This pathway represents a potential target for anti–TNF-α therapies.
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Messenger RNA degradation in eukaryotes
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Self-citationComparing the Means of Several Groups
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Cited by
The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650
Brennan, C. M., & Steitz*, J. A. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000854 · Cited by 1,095
Resolution of inflammation: a new therapeutic frontier
Fullerton, J. N., & Gilroy, D. W. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.39 · Cited by 937
AU-rich elements and associated factors: are there unifying principles?
Barreau, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki1012 · Cited by 907
AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs
Chen, C.-Y., Gherzi, R., Ong, S.-E., Chan, E. L., Raijmakers, R., Pruijn, G. J. M., Stoecklin, G., Moroni, C., Mann, M., & Karin, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00578-5 · Cited by 865
Metadata
- Authors
- Carballo, E., Lai, W. S., & Blackshear, P. J.
- Venue
- Science
- Published
- 1998-08-14
- Volume
- 281
- Issue
- 5379
- Pages
- 1001-1005
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2045714098
- Cited by
- 1,161
- References
- 34
- FWCI
- 11.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Carballo, E., Lai, W. S., & Blackshear, P. J. (1998). Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin. Science. https://doi.org/10.1126/science.281.5379.1001
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
