PreprintCited by 447Genomics and Chromatin Dynamicsinterferon and immune responsesT-cell and B-cell Immunology

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Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

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Eisenbeis, C F, Singh, H, Storb, U·1995·Genes & Development

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Abstract

The immunoglobulin light-chain gene enhancers E kappa 3', E lambda 2-4, and E lambda 3-1 contain a conserved cell type-specific composite element essential for their activities. This element binds a B cell-specific heterodimeric protein complex that consists of the Ets family member PU.1 and a second factor (NF-EM5), whose participation in the formation of the complex is dependent on the presence of DNA-bound PU.1. In this report we describe the cloning and characterization of Pip (PU.1 interaction partner), a lymphoid-specific protein that is most likely NF-EM5. As expected, the Pip protein binds the composite element only in the presence of PU.1; furthermore, the formation of this ternary complex is critically dependent on phosphorylation of PU.1 at serine-148. The Pip gene is expressed specifically in lymphoid tissues in both B- and T-cell lines. When coexpressed in NIH-3T3 cells, Pip and PU.1 function as mutually dependent transcription activators of the composite element. The amino-terminal DNA-binding domain of Pip exhibits a high degree of homology to the DNA-binding domains of members of the interferon regulatory factor (IRF) family, which includes IRF-1, IRF-2, ICSBP, and ISGF3 gamma.

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Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
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Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
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Kozak, M. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.20.8125 · Cited by 5,090
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Rogers, S. W., Wells, R., & Rechsteiner, M. (1986) · Science · doi:10.1126/science.2876518 · Cited by 2,541
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Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532
Self-citation
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes
Banerji, J., Olson, L., & Schaffner, W. (1983) · Cell · doi:10.1016/0092-8674(83)90015-6 · Cited by 1,381
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene
Gillies, S. D., Morrison, S. L., Oi, V. T., & Tonegawa, S. (1983) · Cell · doi:10.1016/0092-8674(83)90014-4 · Cited by 1,361
Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif
Courey, A. J., & Tjian, R. (1988) · Cell · doi:10.1016/0092-8674(88)90144-4 · Cited by 1,353
The Interferon System
Stewart, W. E. (1979) · Springer eBooks · doi:10.1007/978-3-7091-3432-0 · Cited by 1,165
A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes
Singh, H., Sen, R., Baltimore, D., & Sharp, P. A. (1986) · Nature · doi:10.1038/319154a0 · Cited by 1,087
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Authors: Eisenbeis, C. F., Singh, H., & Storb, U.
Affiliations: University of Chicago (US)
ORCID: Singh, H
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1995-06-01
Volume: 9
Issue: 11
Pages: 1377-1387
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.9.11.1377
OpenAlex: W2055192078
Cited by: 447
References: 58
Citations by year: 2026: 4 · 2025: 8 · 2024: 4 · 2023: 7 · 2022: 9 · 2021: 7 · 2020: 12 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 11 · 2013: 17 · 2012: 15
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
American Cancer Society
Arthritis Foundation
National Institutes of Health
U.S. Public Health Service (FM07183)
National Institute of General Medical Sciences (T32GM007281, GM-07281)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: Pip, PU.1, composite components, transcriptional activation, ternary protein complex, B cells, T cells
MeSH terms: Interferon Regulatory Factor-4, Amino Acid Sequence, Base Sequence, Cell Line, Cloning, Molecular, DNA-Binding Proteins, Gene Expression Regulation, Humans, Lymphocytes, Molecular Sequence Data, Transcription Factors, Trans-Activators, Retroviridae Proteins, Oncogenic, Sequence Alignment, Interferon Regulatory Factors

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Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

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