PreprintCited by 447Genomics and Chromatin Dynamicsinterferon and immune responsesT-cell and B-cell Immunology

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Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

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Eisenbeis, C F, Singh, H, Storb, U·1995·Genes & Development

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Abstract

The immunoglobulin light-chain gene enhancers E kappa 3', E lambda 2-4, and E lambda 3-1 contain a conserved cell type-specific composite element essential for their activities. This element binds a B cell-specific heterodimeric protein complex that consists of the Ets family member PU.1 and a second factor (NF-EM5), whose participation in the formation of the complex is dependent on the presence of DNA-bound PU.1. In this report we describe the cloning and characterization of Pip (PU.1 interaction partner), a lymphoid-specific protein that is most likely NF-EM5. As expected, the Pip protein binds the composite element only in the presence of PU.1; furthermore, the formation of this ternary complex is critically dependent on phosphorylation of PU.1 at serine-148. The Pip gene is expressed specifically in lymphoid tissues in both B- and T-cell lines. When coexpressed in NIH-3T3 cells, Pip and PU.1 function as mutually dependent transcription activators of the composite element. The amino-terminal DNA-binding domain of Pip exhibits a high degree of homology to the DNA-binding domains of members of the interferon regulatory factor (IRF) family, which includes IRF-1, IRF-2, ICSBP, and ISGF3 gamma.

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Authors: Eisenbeis, C. F., Singh, H., & Storb, U.
Affiliations: University of Chicago (US)
ORCID: Singh, H
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1995-06-01
Volume: 9
Issue: 11
Pages: 1377-1387
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.9.11.1377
OpenAlex: W2055192078
Cited by: 447
References: 58
Citations by year: 2026: 4 · 2025: 8 · 2024: 4 · 2023: 7 · 2022: 9 · 2021: 7 · 2020: 12 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 11 · 2013: 17 · 2012: 15
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
American Cancer Society
Arthritis Foundation
National Institutes of Health
U.S. Public Health Service (FM07183)
National Institute of General Medical Sciences (T32GM007281, GM-07281)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: Pip, PU.1, composite components, transcriptional activation, ternary protein complex, B cells, T cells
MeSH terms: Interferon Regulatory Factor-4, Amino Acid Sequence, Base Sequence, Cell Line, Cloning, Molecular, DNA-Binding Proteins, Gene Expression Regulation, Humans, Lymphocytes, Molecular Sequence Data, Transcription Factors, Trans-Activators, Retroviridae Proteins, Oncogenic, Sequence Alignment, Interferon Regulatory Factors

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Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

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