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Cited by 237

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Surveying Saccharomyces Genomes to Identify Functional Elements by Comparative DNA Sequence Analysis

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Cliften, Paul F., Hillier, LaDeana W., Fulton, Lucinda, Graves, Tina, Miner, Tracie, Gish, Warren R., Waterston, Robert H., Johnston, Mark·2001·Genome Research
DOI 10.1101/gr.182901
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Abstract

Comparative sequence analysis has facilitated the discovery of protein coding genes and important functional sequences within proteins, but has been less useful for identifying functional sequence elements in nonprotein-coding DNA because the relatively rapid rate of change of nonprotein-coding sequences and the relative simplicity of non-coding regulatory sequence elements necessitates the comparison of sequences of relatively closely related species. We tested the use of comparative DNA sequence analysis to aid identification of promoter regulatory elements, nonprotein-coding RNA genes, and small protein-coding genes by surveying random DNA sequences of several Saccharomyces yeast species, with the goal of learning which species are best suited for comparisons with S. cerevisiae . We also determined the DNA sequence of a few specific promoters and RNA genes of several Saccharomyces species to determine the degree of conservation of known functional elements within the genome. Our results lead us to conclude that comparative DNA sequence analysis will enable identification of functionally conserved elements within the yeast genome, and suggest a path for obtaining this information.

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Metadata

Authors
Cliften, P. F., Hillier, L. W., Fulton, L., Graves, T., Miner, T., Gish, W. R., Waterston, R. H., & Johnston, M.
Venue
Genome Research
Publisher
Cold Spring Harbor Laboratory
Published
2001-07-01
Volume
11
Issue
7
Pages
1175-1186
ISSN
  • 1088-9051 (ISSN-L)
  • 1549-5469
DOI
10.1101/gr.182901
OpenAlex
W2113206920
Cited by
237
References
2
Type
posted content
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Surveying Saccharomyces Genomes to Identify Functional Elements by Comparative DNA Sequence Analysis. https://app.cochat.ai/papers/10.1101/gr.182901
The paper
Cliften, P. F., Hillier, L. W., Fulton, L., Graves, T., Miner, T., Gish, W. R., Waterston, R. H., & Johnston, M. (2001). Surveying Saccharomyces Genomes to Identify Functional Elements by Comparative DNA Sequence Analysis. Genome Research. https://doi.org/10.1101/gr.182901

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