The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Diverse alternative back-splicing and alternative splicing landscape of circular RNAs
Open accessAbstract
Circular RNAs (circRNAs) derived from back-spliced exons have been widely identified as being co-expressed with their linear counterparts. A single gene locus can produce multiple circRNAs through alternative back-splice site selection and/or alternative splice site selection; however, a detailed map of alternative back-splicing/splicing in circRNAs is lacking. Here, with the upgraded CIRCexplorer2 pipeline, we systematically annotated different types of alternative back-splicing and alternative splicing events in circRNAs from various cell lines. Compared with their linear cognate RNAs, circRNAs exhibited distinct patterns of alternative back-splicing and alternative splicing. Alternative back-splice site selection was correlated with the competition of putative RNA pairs across introns that bracket alternative back-splice sites. In addition, all four basic types of alternative splicing that have been identified in the (linear) mRNA process were found within circRNAs, and many exons were predominantly spliced in circRNAs. Unexpectedly, thousands of previously unannotated exons were detected in circRNAs from the examined cell lines. Although these novel exons had similar splice site strength, they were much less conserved than known exons in sequences. Finally, both alternative back-splicing and circRNA-predominant alternative splicing were highly diverse among the examined cell lines. All of the identified alternative back-splicing and alternative splicing in circRNAs are available in the CIRCpedia database (http://www.picb.ac.cn/rnomics/circpedia). Collectively, the annotation of alternative back-splicing and alternative splicing in circRNAs provides a valuable resource for depicting the complexity of circRNA biogenesis and for studying the potential functions of circRNAs in different cells.
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Circular RNAs are abundant, conserved, and associated with ALU repeats
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Self-citationComplementary Sequence-Mediated Exon Circularization
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“…of being covalently closed without open ends, circRNAs are largely missed by polyadenylated transcriptome profiling but can be captured by RNA deep-sequencing (RNA-seq) from nonpolyadenylated RNAs (Yang et al. 2011; Jeck et al. 2013; Memczak et al. 2013; Salzman et al. 2013; Zhang et al. 2014).”
InfluentialSelf-citationRegulation of circRNA biogenesis
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Self-citationThe biogenesis and emerging roles of circular RNAs
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Self-citationA Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains
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Cited by
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Circular RNA: An emerging non-coding RNA as a regulator and biomarker in cancer
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CircNT5E Acts as a Sponge of miR-422a to Promote Glioblastoma Tumorigenesis
Wang, R., Zhang, S., Chen, X., Li, N., Li, J., Jia, R., Pan, Y., & Liang, H. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0532 · Cited by 298
Role of circular RNAs in brain development and CNS diseases
Mehta, S. L., Dempsey, R. J., & Vemuganti, R. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101746 · Cited by 281
Circular RNAs: biogenesis, function, and a role as possible cancer biomarkers
Bolha, L., Ravnik-Glavač, M., & Glavač, D. (2017) · International Journal of Genomics · doi:10.1155/2017/6218353 · Cited by 166
“cn/rnomics/circpedia/ A database holding information on identified and annotated back-splicing and alternative splicing in circRNAs from human, mouse, fly, and worm samples [19]”
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Metadata
- Authors
- Zhang, X.-O., Dong, R., Zhang, Y., Zhang, J.-L., Luo, Z., Zhang, J., Chen, L.-L., & Yang, L.
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2016-06-30
- Volume
- 26
- Issue
- 9
- Pages
- 1277-1287
- ISSN
- 1088-9051 (ISSN-L)
- 1549-5469
- OpenAlex
- W2464424326
- Cited by
- 1,029
- References
- 11
- Type
- posted content
- Language
- en
- Open access
- bronze
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