Cited by 167Memory and Neural MechanismsMemory Processes and InfluencesPosttraumatic Stress Disorder Research

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm

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Abstract

The purpose of this study was to analyze fear extinction and reinstatement in humans using fear-potentiated startle. Participants were fear conditioned using a simple discrimination procedure with colored lights as the conditioned stimuli (CSs) and an airblast to the throat as the unconditioned stimulus (US). Participants were extinguished 24 h after fear conditioning. Upon presentation of unsignaled USs after extinction, participants displayed significant fear reinstatement. In summary, these procedures produced robust fear-potentiated startle, significant CS+/CS− discrimination, within-session extinction, and significant reinstatement. This is the first demonstration of fear extinction and reinstatement in humans using startle measures.

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  1. 10.1037/0003-066X.50.5.372 · DOI
  2. 10.1017/S0048577298970998 · DOI

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Metadata

Authors
Norrholm, S. D., Jovanovic, T., Vervliet, B., Myers, K. M., Davis, M., Rothbaum, B. O., & Duncan, E. J.
Affiliations
  • Emory University (US)
  • University of Amsterdam (NL)
Venue
Learning & Memory
Published
2006-11
Volume
13
Issue
6
Pages
681-685
ISSN
  • 1072-0502 (ISSN-L)
  • 1549-5485
OpenAlex
W2102103246
Cited by
167
References
40
Citations by year
2025: 4 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 7 · 2020: 18 · 2019: 6 · 2018: 9 · 2017: 3 · 2016: 11 · 2015: 14 · 2014: 13 · 2013: 13 · 2012: 8
Type
posted content
Language
en
Open access
Locations
  • Learning & Memory (publishedVersion)
  • PubMed (publishedVersion)
  • UvA-DARE (University of Amsterdam) (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • National Science Foundation (9876754)
  • Woodruff Foundation
  • GlaxoSmithKline
  • Emory University
  • National Institutes of Health (5r24mh067314-03)
  • School of Medicine, Emory University
  • National Institute of Mental Health (1R24MH067314-01A1, MH 47840, R37MH047840, R24 MH067314)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords
fear extinction, fear reinstatement, fear-potentiated startle, fear conditioning, air blast, startle response
MeSH terms
Conditioning, Classical, Discrimination Learning, Extinction, Psychological, Fear, Humans, Psychopharmacology, Psychophysics, Set, Psychology, Reflex, Startle

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