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PreprintCited by 43Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Perforant path activation modulates the induction of long-term potentiation of the schaffer collateral—hippocampal CA1 response: theoretical and experimental analyses

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Levy, W B, Desmond, N L, Zhang, D X·1998·Learning & Memory
DOI 10.1101/lm.4.6.510
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Abstract

In one computational model of hippocampal function, the entorhinal cortical input to CA1 is hypothesized to play a key role in the ability of CA1 to decode CA3 recodings. Here, we develop a modification of this CA1 decoder hypothesis that is applicable to several computational theories of hippocampal function, and then we electrophysiologically investigate one assumption of this new hypothesis. First, using biologically realistic estimates, we calculate that CA3-induced CA1 excitation is too high and that inhibition plausibly plays a role in this CA1 decoder model. Thus motivated, we turn to a physiological demonstration to substantiate the plausibility of the proposed mechanism. Using the rat hippocampal slice, we examine an interlaminar interaction between the distal perforant path input to hippocampal CA1 stratum moleculare and the more proximal Schaffer collateral input to stratum radiatum. Perforant path activation provides sufficient inhibition to block homosynaptic long-term potentiation elicited by a suitably strong stratum radiatum input. For this interlaminar interaction to be most effective, perforant path activation must both precede and follow Schaffer collateral activation. Perforant path-evoked inhibition in CA1 can thus serve as a viable mechanism in the learned decoder theory of hippocampal CA1.

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  • The weak excitatory drive of cortical inputs to CA1 neurons likely restricts these inputs to a modulatory role in regulating CA1 output.

    “The weak excitatory drive of the cortical inputs to CA1 neurons likely restricts these inputs to a modulatory role in regulating CA1 output, for example, providing instructive signals for the induction of plasticity at the more potent CA3 inputs (Dudman et al., 2007; Judge and Hasselmo, 2004; Levy et al., 1998; Remondes and Schuman, 2002).”

    From Strong CA2 Pyramidal Neuron Synapses Define a Powerful Disynaptic Cortico-Hippocampal Loop (2010) · cites this paper as Levy et al., 1998

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Research works printed but not linked: 2

  1. R. Parks and D. Levine). MIT Press, Cambridge, MA.
  2. Levy, W.B, C.M. Colbert, and N.L. Desmond. 1990. Elemental adaptive processes of neurons and synapses: A statistical/computational perspective. In Neuroscience and connectionist theory (ed. M.A. Gluck and D.E. Rumelhart), pp. 187-235.

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Authors
Levy, W. B., Desmond, N. L., & Zhang, D. X.
Affiliations
University of Virginia (US)
ORCID
Levy, W B
Venue
Learning & Memory
Publisher
Cold Spring Harbor Laboratory
Published
1998
Volume
4
Issue
6
Pages
510-518
ISSN
  • 1072-0502 (ISSN-L)
  • 1549-5485
DOI
10.1101/lm.4.6.510
OpenAlex
W2018646762
Cited by
43
References
29
Citations by year
2023: 1 · 2022: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 3 · 2013: 2 · 2012: 2
Type
posted content
Language
en
Open access
Locations
  • Learning & Memory (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh050670-03, 5r01ns015488-19, 5k02mh000622-09)
  • National Institute of Mental Health (R01 MH50670, KO2 MH00622)
  • National Institute of Neurological Disorders and Stroke (R01 NS15488)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
perforant path, Schaffer collaterals, hippocampal CA1, long-term potentiation, stratum moleculare, stratum radiatum, entorhinal cortex, rat hippocampal slices
MeSH terms
Animals, Conditioning, Psychological, Electric Stimulation, Electrophysiology, Hippocampus, Male, Models, Neurological, Rats, Sprague-Dawley, Long-Term Potentiation, Perforant Pathway, Excitatory Postsynaptic Potentials, Rats, In Vitro Techniques

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