A role for synaptic inputs at distal dendrites: instructive signals for hippocampal long-term plasticity

Dudman, Joshua T.; Tsay, David; Siegelbaum, Steven A.

doi:10.1016/j.neuron.2007.10.020

Cited by 192Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

A role for synaptic inputs at distal dendrites: instructive signals for hippocampal long-term plasticity

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Dudman, Joshua T., Tsay, David, Siegelbaum, Steven A.·2007·Neuron

DOI 10.1016/j.neuron.2007.10.020PMC PMC2179894

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Abstract

Synaptic potentials originating at distal dendritic locations are severely attenuated when they reach the soma and, thus, are poor at driving somatic spikes. Nonetheless, distal inputs convey essential information, suggesting that such inputs may be important for compartmentalized dendritic signaling. Here we report a new plasticity rule in which stimulation of distal perforant path inputs to hippocampal CA1 pyramidal neurons induces long-term potentiation at the CA1 proximal Schaffer collateral synapses when the two inputs are paired at a precise interval. This subthreshold form of heterosynaptic plasticity occurs in the absence of somatic spiking but requires activation of both NMDA receptors and IP(3) receptor-dependent release of Ca(2+) from internal stores. Our results suggest that direct sensory information arriving at distal CA1 synapses through the perforant path provide compartmentalized, instructive signals that assess the saliency of mnemonic information propagated through the hippocampal circuit to proximal synapses.

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The weak excitatory drive of cortical inputs to CA1 neurons likely restricts these inputs to a modulatory role in regulating CA1 output.
“The weak excitatory drive of the cortical inputs to CA1 neurons likely restricts these inputs to a modulatory role in regulating CA1 output, for example, providing instructive signals for the induction of plasticity at the more potent CA3 inputs (Dudman et al., 2007; Judge and Hasselmo, 2004; Levy et al., 1998; Remondes and Schuman, 2002).”
From Strong CA2 Pyramidal Neuron Synapses Define a Powerful Disynaptic Cortico-Hippocampal Loop (2010) · cites this paper as Dudman et al., 2007

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Authors: Dudman, J. T., Tsay, D., & Siegelbaum, S. A.
Affiliations: Columbia University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Siegelbaum, Steven A.
ORCID: Dudman, Joshua T.
Siegelbaum, Steven A.
Venue: Neuron
Publisher: Elsevier BV
Published: 2007-12
Volume: 56
Issue: 5
Pages: 866-879
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2007.10.020
PMC: PMC2179894
OpenAlex: W2155200140
Cited by: 192
References: 81
Citations by year: 2026: 2 · 2025: 8 · 2024: 6 · 2023: 8 · 2022: 11 · 2021: 13 · 2020: 7 · 2019: 12 · 2018: 10 · 2017: 13 · 2016: 13 · 2015: 9 · 2014: 14 · 2013: 10 · 2012: 14
FWCI: 3.98
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2091 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (T32 MH015174-30)
Howard Hughes Medical Institute
National Science Foundation
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: distal dendrites, hippocampal CA1, long-term potentiation, heterosynaptic plasticity, perforant path, Schaffer collateral synapses, NMDA receptor, IP3 receptor, paired stimulation, pyramidal neurons, synaptic plasticity rules
MeSH terms: Animals, Calcium, Computer Simulation, Dendrites, Electrophysiology, Hippocampus, Memory, Models, Neurological, Synaptic Transmission, Neuronal Plasticity, Recruitment, Neurophysiological, Synapses, Signal Transduction, Absorptiometry, Photon, Receptors, N-Methyl-D-Aspartate, Pyramidal Cells, Receptors, AMPA, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Dendritic Spines, Mice, Inositol 1,4,5-Trisphosphate Receptors

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A role for synaptic inputs at distal dendrites: instructive signals for hippocampal long-term plasticity

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