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Cited by 647Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Synaptic enhancement in fascia dentata: Cooperativity among coactive afferents

McNaughton, B.L., Douglas, R.M., Goddard, G.V.·1978·Brain Research
DOI 10.1016/0006-8993(78)90030-6
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Abstract

Evidence is presented that long-lasting enhancement of perforant path synapses following high-frequency activity is a cooperative process requiring coactivity of a considerable number of fibers. This was demonstrated in two ways: (1) A threshold stimulus intensity during high-frequency stimulation was required before any enhancement was observed. This threshold was considerably above the stimulus threshold for observing a minimal synaptic response in the fascia dentata. Above the enhancement threshold, the amount of enhancement increased as the intensity of high-frequency stimulation increased. (2) Concurrent high-frequency activation of fibres of the medial and lateral perforant path produced enhancement at intensities where identical but independent stimulation of the two pathways either failed or was less effective. Discharge of the granule cells during the high-frequency stimulation was independently manipulated and found not to be physically coupled to the enhancement generating mechanism.

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Crossref · 10.1016/0006-8993(78)90030-6

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2 of 2 references verified0 citation errors · 0 not checkable

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • LTP has cooperativity.

    “Another property of LTP is cooperativity (39).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [39]

  • Tetanizing just a single or a few axons fails to express LTP on a given postsynaptic cell, no matter the frequency of stimulation.

    “If one tetanizes just a single or a few axons, the activated synapse(s) on a given postsynaptic cell fails to express LTP, no matter the frequency of stimulation.”

    From Synaptic memory and CaMKII (2023) · cites this paper as [39]

  • LTP is induced when stimulus strength is increased so that many more axons are activated.

    “However, LTP is induced when the stimulus strength is increased so that many more axons are activated.”

    From Synaptic memory and CaMKII (2023) · cites this paper as [39]

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Authors
McNaughton, B. L., Douglas, R. M., & Goddard, G. V.
Affiliations
Dalhousie University (CA)
Venue
Brain Research
Publisher
Elsevier BV
Published
1978-11
Volume
157
Issue
2
Pages
277-293
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(78)90030-6
OpenAlex
W1983923341
Cited by
647
References
2
Citations by year
2025: 8 · 2024: 7 · 2023: 9 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 13 · 2017: 12 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 11 · 2012: 11
FWCI
2.30
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
synaptic potentiation, perforant path, dentate gyrus, high-frequency stimulation, synaptic plasticity, granule cells, medial perforant path, lateral perforant path, hippocampus
MeSH terms
Afferent Pathways, Animals, Differential Threshold, Electric Stimulation, Electrophysiology, Evoked Potentials, Hippocampus, Functional Laterality, Male, Nerve Fibers, Synapses, Wakefulness, Rats

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