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Hippocampal Damage and Exploratory Preferences in Rats: Memory for Objects, Places, and Contexts

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Mumby, Dave G., Gaskin, Stephane, Glenn, Melissa J., Schramek, Tania E., Lehmann, Hugo·2002·Learning & Memory

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Abstract

Rats have a natural tendency to spend more time exploring novel objects than familiar objects, and this preference can be used as an index of object recognition. Rats also show an exploratory preference for objects in locations where they have not previously encountered objects (an index of place memory) and for familiar objects in contexts different from those in which the objects were originally encountered (an index of context memory). In this experiment, rats with cytotoxic lesions of the hippocampal formation were tested on all three versions of the novelty-preference paradigm, with a 5-min retention interval between the familiarization and test phases. Rats with sham lesions displayed a novelty preference on all three trial types, whereas the rats with hippocampal lesions displayed a novelty preference on Object trials but did not discriminate between the objects on Place trials or Context trials. The findings indicate that hippocampal damage impairs memory for contextual or spatial aspects of an experience, whereas memory for objects that were part of the same experience are left relatively intact.

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Untitled work
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
Book Reviews: Keppel, Geoffrey. Design and Analysis: A Researcher’s Handbook . Englewood Cliffs, N. J.: Prentice Hall, 1973. 658 + xiii pp. $13.95
Beaton, A. E., & Keppel, G. (1975) · American Educational Research Journal · doi:10.2307/1162588 · Cited by 5,857
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Memory consolidation, retrograde amnesia and the hippocampal complex
Nadel, L., & Moscovitch, M. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80010-4 · Cited by 1,924
Episodic memory, amnesia, and the hippocampal–anterior thalamic axis
Aggleton, J. P., & Brown, M. W. (1999) · Behavioral and Brain Sciences · doi:10.1017/s0140525x99002034 · Cited by 1,879
A cortical–hippocampal system for declarative memory
Eichenbaum, H. (2000) · Nature reviews. Neuroscience · doi:10.1038/35036213 · Cited by 1,817
Two functional components of the hippocampal memory system
Eichenbaum, H., Otto, T., & Cohen, N. J. (1994) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00035391 · Cited by 1,114
The hippocampus and contextual retrieval of information from memory: A theory
Hirsh, R. (1974) · Behavioral Biology · doi:10.1016/s0091-6773(74)92231-7 · Cited by 957

Flagged first, then by citations

Show all 44 references

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10.1037/0735-7044.111.6.1184 · DOI
Glenn, 1996, Place- and object-recognition deficits following lesions of the hippocampus or perirhinal cortex in rats: A double dissociation., Society for Neuroscience Abstracts, 22, 1120
10.1037/0735-7044.110.2.266 · DOI

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Siegel, J. A., Craytor, M. J., & Raber, J. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833e7e44 · Cited by 43
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Authors: Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., & Lehmann, H.
Affiliations: Concordia University (CA)
ORCID: Mumby, Dave G.
Glenn, Melissa J.
Lehmann, Hugo
Venue: Learning & Memory
Publisher: Cold Spring Harbor Laboratory
Published: 2002-03-01
Volume: 9
Issue: 2
Pages: 49-57
ISSN: 1072-0502 (ISSN-L)
1549-5485
DOI: 10.1101/lm.41302
PMC: PMC155935
OpenAlex: W2024032885
Cited by: 714
References: 44
Citations by year: 2026: 11 · 2025: 17 · 2024: 19 · 2023: 24 · 2022: 28 · 2021: 26 · 2020: 36 · 2019: 34 · 2018: 37 · 2017: 28 · 2016: 36 · 2015: 30 · 2014: 49 · 2013: 43 · 2012: 55
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Learning & Memory (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Social Sciences › Psychology › Experimental and Cognitive Psychology › Spatial Cognition and Navigation
Keywords: hippocampal lesions, novelty preference, object recognition memory, place memory, contextual memory, spatial memory, hippocampal formation, rats, cytotoxic lesions, memory impairment
MeSH terms: Animals, Behavior, Animal, Choice Behavior, Exploratory Behavior, Hippocampus, Male, Memory, Pattern Recognition, Visual, Space Perception, Rats, Long-Evans, Rats

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Hippocampal Damage and Exploratory Preferences in Rats: Memory for Objects, Places, and Contexts

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