Cited by 396Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsCancer-related Molecular Pathways

The DOI matches its Crossref record.

Telomerase, Cell Immortality, and Cancer

Harley, C.B., Kim, N.W., Prowse, K.R., Weinrich, S.L., Hirsch, K.S., West, M.D., Bacchetti, S., Hirte, H.W., Counter, C.M., Greider, C.W., Piatyszek, M.A., Wright, W.E., Shay, J.W.·1994·Cold Spring Harbor Symposia on Quantitative Biology

DOI 10.1101/sqb.1994.059.01.035

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Abstract

An important hallmark of cancer is aberrant growth control. Genetic changes that confer a growth advantage to the tumor cell are observed on numerous levels. Some of the best understood are mutations in proto-oncogenes and tumor suppressor genes that are linked to signal transduction pathways, cell cycle control, or cell-cell/cell-matrix interactions that regulate growth, movement, differentiation, survival, apoptosis, and genetic stability (Hartwell 1992; Weinberg 1992; Hunter 1993; Runger et al. 1994; Workman 1994). However, in addition to aberrant growth control, many cancer cells possess another important feature which distinguishes them from normal somatic cells: unlimited replicative capacity.

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Crossref · 10.1101/sqb.1994.059.01.035

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Authors: Harley, C. B., Kim, N. W., Prowse, K. R., Weinrich, S. L., Hirsch, K. S., West, M. D., Bacchetti, S., Hirte, H. W., Counter, C. M., Greider, C. W., Piatyszek, M. A., Wright, W. E., & Shay, J. W.
Affiliations: Cold Spring Harbor Laboratory (US)
ORCID: West, M.D.
Hirte, H.W.
Counter, C.M.
Greider, C.W.
Piatyszek, M.A.
Wright, W.E.
Shay, J.W.
Venue: Cold Spring Harbor Symposia on Quantitative Biology
Publisher: Cold Spring Harbor Laboratory
Published: 1994-01-01
Volume: 59
Issue: 0
Pages: 307-315
ISSN: 0091-7451 (ISSN-L)
1943-4456
DOI: 10.1101/sqb.1994.059.01.035
OpenAlex: W2064208421
Cited by: 396
References: 0
Citations by year: 2025: 3 · 2024: 1 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 9 · 2016: 3 · 2015: 7 · 2014: 9 · 2013: 3 · 2012: 8
Type: posted content
Language: en
Open access: closed
Locations: Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: telomerase, cell immortalization, cancer, tumor growth control, proto-oncogenes, tumor suppressor, signal transduction, cell cycle regulation, apoptosis, genetic stability
MeSH terms: Antineoplastic Agents, Cell Transformation, Neoplastic, DNA Replication, Enzyme Inhibitors, Female, Humans, Male, Models, Biological, Neoplasms, Phenotype, Cellular Senescence, Telomerase

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Telomerase, Cell Immortality, and Cancer

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