The DOI matches its Crossref record.
Telomerase, Cell Immortality, and Cancer
Abstract
An important hallmark of cancer is aberrant growth control. Genetic changes that confer a growth advantage to the tumor cell are observed on numerous levels. Some of the best understood are mutations in proto-oncogenes and tumor suppressor genes that are linked to signal transduction pathways, cell cycle control, or cell-cell/cell-matrix interactions that regulate growth, movement, differentiation, survival, apoptosis, and genetic stability (Hartwell 1992; Weinberg 1992; Hunter 1993; Runger et al. 1994; Workman 1994). However, in addition to aberrant growth control, many cancer cells possess another important feature which distinguishes them from normal somatic cells: unlimited replicative capacity.
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“A total lifetime loss of ~2-4 kb in average telomere length has been observed in human cells8-10.”
From Telomere dysfunction and tumour suppression: the senescence connection (2008) · cites this paper as [10]
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Metadata
- Authors
- Harley, C. B., Kim, N. W., Prowse, K. R., Weinrich, S. L., Hirsch, K. S., West, M. D., Bacchetti, S., Hirte, H. W., Counter, C. M., Greider, C. W., Piatyszek, M. A., Wright, W. E., & Shay, J. W.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1994-01-01
- Volume
- 59
- Issue
- 0
- Pages
- 307-315
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2064208421
- Cited by
- 396
- References
- 0
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 9 · 2016: 3 · 2015: 7 · 2014: 9 · 2013: 3 · 2012: 8
- Type
- posted content
- Language
- en
- Open access
- closed
- Locations
- Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- telomerase, cell immortalization, cancer, tumor growth control, proto-oncogenes, tumor suppressor, signal transduction, cell cycle regulation, apoptosis, genetic stability
- MeSH terms
- Antineoplastic Agents, Cell Transformation, Neoplastic, DNA Replication, Enzyme Inhibitors, Female, Humans, Male, Models, Biological, Neoplasms, Phenotype, Cellular Senescence, Telomerase
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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