The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
High-Affinity Manganese Uptake by the Metal Transporter NRAMP1 Is Essential for Arabidopsis Growth in Low Manganese Conditions
Open accessAbstract
In contrast with many other essential metals, the mechanisms of Mn acquisition in higher eukaryotes are seldom studied and poorly understood. We show here that Arabidopsis thaliana relies on a high-affinity uptake system to acquire Mn from the soil in conditions of low Mn availability and that this activity is catalyzed by the divalent metal transporter NRAMP1 (for Natural Resistance Associated Macrophage Protein 1). The nramp1-1 loss-of-function mutant grows poorly, contains less Mn than the wild type, and fails to take up Mn in conditions of Mn limitation, thus demonstrating that NRAMP1 is the major high-affinity Mn transporter in Arabidopsis. Based on confocal microscopy observation of an NRAMP1-green fluorescent protein fusion, we established that NRAMP1 is localized to the plasma membrane. Consistent with its function in Mn acquisition from the soil, NRAMP1 expression is restricted to the root and stimulated by Mn deficiency. Finally, we show that NRAMP1 restores the capacity of the iron-regulated transporter1 mutant to take up iron and cobalt, indicating that NRAMP1 has a broad selectivity in vivo. The role of transporters of the NRAMP family is well established in higher eukaryotes for iron but has been controversial for Mn. This study demonstrates that NRAMP1 is a physiological manganese transporter in Arabidopsis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166
IRT1, an Arabidopsis Transporter Essential for Iron Uptake from the Soil and for Plant Growth
Vert, G., Grotz, N., Dédaldéchamp, F., Gaymard, F., Guerinot, M. L., Briat, J.-F., & Curie, C. (2002) · The Plant Cell · doi:10.1105/tpc.001388 · Cited by 1,679
Self-citationMicrocytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., & Andrews, N. C. (1997) · Nature Genetics · doi:10.1038/ng0897-383 · Cited by 1,159
Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg
Vidal, S. M., Malo, D., Vogan, K., Skamene, E., & Gros, P. (1993) · Cell · doi:10.1016/0092-8674(93)90135-d · Cited by 1,104
Krämer, U., Talke, I. N., & Hanikenne, M. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.04.010 · Cited by 583
Supek, F., Supekova, L., Nelson, H., & Nelson, N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.5105 · Cited by 325
Kehres, D. G., Zaharik, M. L., Finlay, B. B., & Maguire, M. E. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01922.x · Cited by 292
A secretory pathway-localized cation diffusion facilitator confers plant manganese tolerance
Peiter, E., Montanini, B., Gobert, A., Pedas, P., Husted, S., Maathuis, F. J. M., Blaudez, D., Chalot, M., & Sanders, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609507104 · Cited by 287
The Thlaspi caerulescens NRAMP homologue TcNRAMP3 is capable of divalent cation transport
Wei, W., Chai, T., Zhang, Y., Han, L., Xu, J., & Guan, Z. (2009) · Molecular Biotechnology · doi:10.1007/s12033-008-9088-x · Cited by 94
Cited by
Phytoremediation: A Promising Approach for Revegetation of Heavy Metal-Polluted Land
Yan, A., Wang, Y., Tan, S. N., Mohd Yusof, M. L., Ghosh, S., & Chen, Z. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00359 · Cited by 1,644
Manganese in Plants: From Acquisition to Subcellular Allocation
Alejandro, S., Höller, S., Meier, B., & Peiter, E. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00300 · Cited by 859
The OsNRAMP1 iron transporter is involved in Cd accumulation in rice
Takahashi, R., Ishimaru, Y., Senoura, T., Shimo, H., Ishikawa, S., Arao, T., Nakanishi, H., & Nishizawa, N. K. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/err136 · Cited by 591
Trace metal metabolism in plants
Andresen, E., Peiter, E., & Küpper, H. (2018) · Journal of Experimental Botany · doi:10.1093/jxb/erx465 · Cited by 431
Molecular mechanisms governing Arabidopsis iron uptake
Brumbarova, T., Bauer, P., & Ivanov, R. (2015) · Trends in Plant Science · doi:10.1016/j.tplants.2014.11.004 · Cited by 332
Metadata
- Authors
- Cailliatte, R., Schikora, A., Briat, J.-F., Mari, S., & Curie, C.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-03-01
- Volume
- 22
- Issue
- 3
- Pages
- 904-917
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2132519271
- Cited by
- 506
- References
- 9
- FWCI
- 21.83
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: High-Affinity Manganese Uptake by the Metal Transporter NRAMP1 Is Essential for Arabidopsis Growth in Low Manganese Conditions. https://app.cochat.ai/papers/10.1105/tpc.109.073023
- The paper
- Cailliatte, R., Schikora, A., Briat, J.-F., Mari, S., & Curie, C. (2010). High-Affinity Manganese Uptake by the Metal Transporter NRAMP1 Is Essential for Arabidopsis Growth in Low Manganese Conditions. The Plant Cell. https://doi.org/10.1105/tpc.109.073023
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
